Alteration of pyocin-sensitivity pattern of Neisseria gonorrhoeae is associated with induced resistance to killing by human serum.

A laboratory-grown strain of Neisseria gonorrhoeae, selected in vivo, BS4 (agar), is susceptible to complement-mediated killing by fresh human serum but is relatively resistant to killing by human phagocytes. It can be induced to serum resistance by incubation with a small molecular weight fraction of guinea pig serum. The serum-susceptible and induced-resistant forms show differences in pyocin sensitivity tests. This indicates either differences in the structure of their lipopolysaccharides or masking of some determinant(s). The pyocin sensitivity pattern of BS4 (agar) is only slightly different from that of a closely related strain, BSSH, which is more susceptible to killing by human phagocytes.

[1]  A. Glynn,et al.  The Elusive Determinants of Bacterial Interference with Non-Specific Host Defences [and Discussion] , 1983 .

[2]  D. Kinane,et al.  Blood groups and susceptibility to gonococcal infection. II. The relationship of lipopolysaccharide type to gonococcal sensitivity to the bactericidal activity of normal human serum. , 1983, Journal of clinical & laboratory immunology.

[3]  D. Kinane,et al.  ABO blood group and susceptibility to gonococcal infection. I. Factors affecting phagocytosis of Neisseria gonorrhoeae. , 1983, Journal of clinical & laboratory immunology.

[4]  H. Smith,et al.  Outer membrane proteins of Neisseria gonorrhoeae associated with survival within human polymorphonuclear phagocytes. , 1982, Journal of general microbiology.

[5]  W. Shafer,et al.  Pyocin-resistant lipopolysaccharide mutans of Neisseria gonorrhoeae: alterations in sensitivity to normal human serum and polymyxin B , 1982, Infection and immunity.

[6]  C. Lammel,et al.  Relation of protein I and colony opacity to serum killing of Neisseria gonorrhoeae. , 1982, The Journal of infectious diseases.

[7]  G. Pier,et al.  Immunological basis of serum resistance of Neisseria gonorrhoeae. , 1982, Journal of general microbiology.

[8]  C. Penn,et al.  Investigation of the determinants of the survival of Neisseria gonorrhoeae within human polymorphonuclear phagocytes. , 1981, Journal of general microbiology.

[9]  H. Smith,et al.  Induction of phenotypically determined resistance of Neisseria gonorrhoeae to human serum by factors in human serum. , 1981, Journal of general microbiology.

[10]  C. Penn,et al.  Factors affecting the induction of phenotypically determined serum resistance of Neisseria gonorrhoeae grown in media containing serum or its diffusible components. , 1981, Journal of general microbiology.

[11]  P. Watt,et al.  Variations in surface protein composition associated with virulence properties in opacity types of Neisseria gonorrhoeae. , 1979, Journal of general microbiology.

[12]  H. Young,et al.  Sensitivity of Neisseria gonorrhoeae to partially purified R-type pyocines and a possible approach to epidemiological typing. , 1979, Journal of medical microbiology.

[13]  P. Meadow,et al.  Receptor Sites for R-type Pyocins and Bacteriophage E79 in the Core Part of the Lipopolysaccharide of Pseudomonas aeruginosaPAC1 , 1978 .

[14]  A. Glauert,et al.  Demonstration by light and electron microscopy of capsules on gonococci recently grown in vivo. , 1978, Journal of general microbiology.

[15]  C. Penn,et al.  Selection from gonococci grown in vitro of a colony type with some virulence properties of organisms adapted in vivo. , 1977, Journal of general microbiology.

[16]  J. Sadoff,et al.  Pyocin sensitivity of Neisseria gonorrhoeae and its feasibility as an epidemiological tool , 1977, Infection and immunity.

[17]  C. Penn,et al.  Morphological, biological and antigenic properties of Neisseria gonorrhoeae adapted to growth in guinea-pig subcutaneous chambers. , 1976, Journal of general microbiology.

[18]  S. Morse,et al.  Inhibition of Neisseria gonorrhoeae by a Bacteriocin from Pseudomonas aeruginosa , 1976, Antimicrobial Agents and Chemotherapy.