Gambogic Acid Sensitizes Ovarian Cancer Cells to Doxorubicin Through ROS-Mediated Apoptosis
暂无分享,去创建一个
[1] A. C. Uguz,et al. Melatonin potentiates chemotherapy‐induced cytotoxicity and apoptosis in rat pancreatic tumor cells , 2012, Journal of pineal research.
[2] Jia Wei,et al. Enhancement of anticancer efficacy of chemotherapeutics by gambogic acid against gastric cancer cells. , 2012, Cancer biotherapy & radiopharmaceuticals.
[3] F. Pinguet,et al. Intraperitoneal administration of novel doxorubicin loaded polymeric delivery systems against peritoneal carcinomatosis: experimental study in a murine model of ovarian cancer. , 2011, Gynecologic oncology.
[4] R. Coleman,et al. Management Strategies for Recurrent Platinum-Resistant Ovarian Cancer , 2011, Drugs.
[5] Richard G. Moore,et al. Tetrathiomolybdate induces doxorubicin sensitivity in resistant tumor cell lines. , 2011, Gynecologic oncology.
[6] B. Aggarwal,et al. Gambogic Acid Inhibits STAT3 Phosphorylation through Activation of Protein Tyrosine Phosphatase SHP-1: Potential Role in Proliferation and Apoptosis , 2011, Cancer Prevention Research.
[7] L. Juillerat-Jeanneret,et al. Drug combinations with quercetin: doxorubicin plus quercetin in human breast cancer cells , 2011, Cancer Chemotherapy and Pharmacology.
[8] Di Chen,et al. Gambogic acid enhances proteasome inhibitor-induced anticancer activity. , 2011, Cancer letters.
[9] R. Hu,et al. Gambogic acid triggers DNA damage signaling that induces p53/p21(Waf1/CIP1) activation through the ATR-Chk1 pathway. , 2010, Cancer letters.
[10] P. Dent,et al. Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction , 2010, Proceedings of the National Academy of Sciences.
[11] A. Jemal,et al. Cancer Statistics, 2010 , 2010, CA: a cancer journal for clinicians.
[12] M. Fukuoka,et al. Marked anti-tumour activity of the combination of YM155, a novel survivin suppressant, and platinum-based drugs , 2010, British Journal of Cancer.
[13] J. K. Kundu,et al. Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model: eukaryotic elongation factor 1A2 as a potential target. , 2009, Cancer research.
[14] Cristina Carvalho,et al. Doxorubicin: the good, the bad and the ugly effect. , 2009, Current medicinal chemistry.
[15] Yan Chen,et al. Gambogic acid induces G0/G1 arrest and apoptosis involving inhibition of SRC-3 and inactivation of Akt pathway in K562 leukemia cells. , 2009, Toxicology.
[16] Jie Zhao,et al. Gambogic acid reduced bcl-2 expression via p53 in human breast MCF-7 cancer cells , 2009, Journal of Cancer Research and Clinical Oncology.
[17] Peng Huang,et al. Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? , 2009, Nature Reviews Drug Discovery.
[18] Yong Yang,et al. Reactive oxygen species accumulation contributes to gambogic acid-induced apoptosis in human hepatoma SMMC-7721 cells. , 2009, Toxicology.
[19] Qing Zhao,et al. Synergistic effect of 5-fluorouracil with gambogic acid on BGC-823 human gastric carcinoma. , 2009, Toxicology.
[20] J. Tao,et al. Gambogic acid induces apoptosis by regulating the expression of Bax and Bcl‐2 and enhancing caspase‐3 activity in human malignant melanoma A375 cells , 2009, International journal of dermatology.
[21] Jie Zhao,et al. Gambogic acid mediates apoptosis as a p53 inducer through down-regulation of mdm2 in wild-type p53-expressing cancer cells , 2008, Molecular Cancer Therapeutics.
[22] Yong Yang,et al. Microtubule depolymerization and phosphorylation of c-Jun N-terminal kinase-1 and p38 were involved in gambogic acid induced cell cycle arrest and apoptosis in human breast carcinoma MCF-7 cells. , 2008, Life sciences.
[23] Jia Wei,et al. Gambogic acid, a potent inhibitor of survivin, reverses docetaxel resistance in gastric cancer cells. , 2008, Cancer letters.
[24] Mingyao Liu,et al. Gambogic acid inhibits angiogenesis and prostate tumor growth by suppressing vascular endothelial growth factor receptor 2 signaling. , 2008, Cancer research.
[25] Anil K Sood,et al. Early events in the pathogenesis of epithelial ovarian cancer. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[26] B. Aggarwal,et al. Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappaB signaling pathway. , 2007, Blood.
[27] Yong Yang,et al. Differential apoptotic induction of gambogic acid, a novel anticancer natural product, on hepatoma cells and normal hepatocytes. , 2007, Cancer letters.
[28] A. Panthong,et al. Anti-inflammatory, analgesic and antipyretic activities of the extract of gamboge from Garcinia hanburyi Hook f. , 2007, Journal of ethnopharmacology.
[29] L. Ding,et al. Determination of gambogic acid in human plasma by liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry. , 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
[30] Hai-wei Zhang,et al. Gambogic acid-induced G2/M phase cell-cycle arrest via disturbing CDK7-mediated phosphorylation of CDC2/p34 in human gastric carcinoma BGC-823 cells. , 2006, Carcinogenesis.
[31] Q. Qi,et al. Toxicological studies of gambogic acid and its potential targets in experimental animals. , 2006, Basic & clinical pharmacology & toxicology.
[32] A. Nudelman,et al. Doxorubicin-DNA adducts induce a non-topoisomerase II-mediated form of cell death. , 2006, Cancer research.
[33] Li Zhao,et al. Anticancer effect and apoptosis induction of gambogic acid in human gastric cancer line BGC-823. , 2005, World journal of gastroenterology.
[34] R. Ozols. Treatment goals in ovarian cancer , 2005, International Journal of Gynecologic Cancer.
[35] H. Hosoi,et al. Fenretinide induces sustained‐activation of JNK/p38 MAPK and apoptosis in a reactive oxygen species‐dependent manner in neuroblastoma cells , 2004, International journal of cancer.
[36] E. Kohn,et al. Proteomics and ovarian cancer: implications for diagnosis and treatment: a critical review of the recent literature , 2004, Current opinion in oncology.
[37] Q. You,et al. Gambogic acid induces apoptosis and regulates expressions of Bax and Bcl-2 protein in human gastric carcinoma MGC-803 cells. , 2004, Biological & pharmaceutical bulletin.
[38] Q. You,et al. General gambogic acids inhibited growth of human hepatoma SMMC-7721 cells in vitro and in nude mice. , 2004, Acta pharmacologica Sinica.
[39] S. Kasibhatla,et al. Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assay. , 2004, Bioorganic & medicinal chemistry.
[40] G. Mills,et al. Sustained Activation of JNK/p38 MAPK Pathways in Response to Cisplatin Leads to Fas Ligand Induction and Cell Death in Ovarian Carcinoma Cells* , 2003, Journal of Biological Chemistry.
[41] B. Aggarwal,et al. Chemopreventive Agents Induce Suppression of Nuclear Factor‐κB Leading to Chemosensitization , 2002, Annals of the New York Academy of Sciences.
[42] R. Berkowitz,et al. The clinical utility of liposomal doxorubicin in recurrent ovarian cancer. , 2001, Gynecologic oncology.
[43] B. Fanburg,et al. Reactive oxygen species in cell signaling. , 2000, American journal of physiology. Lung cellular and molecular physiology.
[44] D. Gewirtz,et al. A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. , 1999, Biochemical pharmacology.
[45] Kohei Miyazono,et al. Mammalian thioredoxin is a direct inhibitor of apoptosis signal‐regulating kinase (ASK) 1 , 1998, The EMBO journal.
[46] S. Rajagopalan,et al. Adriamycin activation and oxygen free radical formation in human breast tumor cells: protective role of glutathione peroxidase in adriamycin resistance. , 1989, Cancer research.
[47] D. Gerlier,et al. Use of MTT colorimetric assay to measure cell activation. , 1986, Journal of immunological methods.
[48] Wang Jin-wan. PhaseIhuman tolerability trial of gambogic acid , 2007 .
[49] R. Ozols,et al. Focus on epithelial ovarian cancer. , 2004, Cancer cell.
[50] N. Dubrawsky. Cancer statistics , 1989, CA: a cancer journal for clinicians.
[51] T. Chou,et al. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. , 1984, Advances in enzyme regulation.