The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome.
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John T. Melchior | Richard G. Lee | B. Cravatt | H. Brown | P. Ivanova | S. Milne | C. Heier | U. Taschler | R. Zimmermann | J. M. Brown | Amanda L. Brown | D. Myers | Matt Davis | M. Graham | R. Crooke | J. Sawyer | A. Howlett | C. Lord | Stephanie M. Marshall | G. Thomas | J. Betters | D. Ferguson | Matthew A. Davis | Lawrence C. Blume | Irina Mrak | V. Leber | J. Blankman | Jacqueline L. Blankman | J. Melchior | R. Lee | J. Mark Brown
[1] J. M. Brown,et al. Mammalian alpha beta hydrolase domain (ABHD) proteins: Lipid metabolizing enzymes at the interface of cell signaling and energy metabolism. , 2013, Biochimica et biophysica acta.
[2] G. Siuzdak,et al. ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC , 2013, Proceedings of the National Academy of Sciences.
[3] Thierry Hotelier,et al. ESTHER, the database of the α/β-hydrolase fold superfamily of proteins: tools to explore diversity of functions , 2012, Nucleic Acids Res..
[4] Carsten Bergmann,et al. Targeted next-generation sequencing identifies a homozygous nonsense mutation in ABHD12, the gene underlying PHARC, in a family clinically diagnosed with Usher syndrome type 3 , 2012, Orphanet Journal of Rare Diseases.
[5] Alka Malhotra,et al. Evidence for a Role of LPGAT1 in Influencing BMI and Percent Body Fat in Native Americans , 2012, Obesity.
[6] J. Moffat,et al. A genome wide shRNA screen identifies α/β hydrolase domain containing 4 (ABHD4) as a novel regulator of anoikis resistance , 2012, Apoptosis.
[7] M. S. Miller,et al. A Gated-7T MRI Technique for Tracking Lung Tumor Development and Progression in Mice after Exposure to Low Doses of Ionizing Radiation , 2012, Radiation research.
[8] J. Laitinen,et al. The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors , 2012, Acta physiologica.
[9] Yurii S. Aulchenko,et al. Genome-Wide Association Study Identifies Novel Loci Associated with Circulating Phospho- and Sphingolipid Concentrations , 2012, PLoS genetics.
[10] Richard G. Lee,et al. CGI-58/ABHD5-Derived Signaling Lipids Regulate Systemic Inflammation and Insulin Action , 2012, Diabetes.
[11] H. Brown,et al. Quantitative analysis of glycerophospholipids by LC-MS: acquisition, data handling, and interpretation. , 2011, Biochimica et biophysica acta.
[12] K. Mackie,et al. COX‐2 and fatty acid amide hydrolase can regulate the time course of depolarization‐induced suppression of excitation , 2011, British journal of pharmacology.
[13] J. Long,et al. The metabolic serine hydrolases and their functions in mammalian physiology and disease. , 2011, Chemical reviews.
[14] G. Siuzdak,et al. Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids , 2011, Nature chemical biology.
[15] R. Vancini,et al. Structural mutants of dengue virus 2 transmembrane domains exhibit host-range phenotype , 2011, Virology Journal.
[16] M. Mclaughlin,et al. Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression , 2011, Cell.
[17] Jing Yang,et al. Antisense oligonucleotides targeting abhydrolase domain containing 2 block human hepatitis B virus propagation. , 2011, Oligonucleotides.
[18] R. Zechner,et al. Monoglyceride Lipase Deficiency in Mice Impairs Lipolysis and Attenuates Diet-induced Insulin Resistance* , 2011, The Journal of Biological Chemistry.
[19] Sherry L. Niessen,et al. Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening , 2010, Proceedings of the National Academy of Sciences.
[20] John T. Melchior,et al. CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance[S] , 2010, Journal of Lipid Research.
[21] N. Drouot,et al. Mutations in ABHD12 cause the neurodegenerative disease PHARC: An inborn error of endocannabinoid metabolism. , 2010, American journal of human genetics.
[22] Peter T. Nguyen,et al. Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system , 2010, Nature Neuroscience.
[23] Agnes L. Bodor,et al. The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors , 2010, Nature Neuroscience.
[24] Vidya Subramanian,et al. CGI-58/ABHD5 is a coenzyme A-dependent lysophosphatidic acid acyltransferase , 2010, Journal of Lipid Research.
[25] J. Aoki,et al. Emerging lysophospholipid mediators, lysophosphatidylserine, lysophosphatidylthreonine, lysophosphatidylethanolamine and lysophosphatidylglycerol. , 2009, Prostaglandins & other lipid mediators.
[26] R. Zechner,et al. Neutral lipid storage disease: genetic disorders caused by mutations in adipose triglyceride lipase/PNPLA2 or CGI-58/ABHD5. , 2009, American journal of physiology. Endocrinology and metabolism.
[27] D. Nomura,et al. Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism. , 2009, Chemistry & biology.
[28] T. Hla,et al. Lysophospholipid receptors in vertebrate development, physiology, and pathology Published, JLR Papers in Press, December 8, 2008. , 2009, Journal of Lipid Research.
[29] D. Gardner,et al. Transcriptome analysis of in vivo and in vitro matured bovine MII oocytes. , 2009, Theriogenology.
[30] P. He,et al. Age-related pulmonary emphysema in mice lacking alpha/beta hydrolase domain containing 2 gene. , 2009, Biochemical and biophysical research communications.
[31] Heather M. Alger,et al. Inhibition of Stearoyl-Coenzyme A Desaturase 1 Dissociates Insulin Resistance and Obesity From Atherosclerosis , 2008, Circulation.
[32] R. Rajasekharan,et al. CGI-58, the Causative Gene for Chanarin-Dorfman Syndrome, Mediates Acylation of Lysophosphatidic Acid* , 2008, Journal of Biological Chemistry.
[33] G. Marsicano,et al. Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice. , 2008, The Journal of clinical investigation.
[34] Sun Young Lee,et al. Lysophosphatidylglycerol stimulates chemotactic migration in human natural killer cells. , 2008, Biochemical and biophysical research communications.
[35] Thomas L. Smith,et al. Targeted Depletion of Hepatic ACAT2-driven Cholesterol Esterification Reveals a Non-biliary Route for Fecal Neutral Sterol Loss* , 2008, Journal of Biological Chemistry.
[36] R. Schneiter,et al. Lipid signalling in disease , 2008, Nature Reviews Molecular Cell Biology.
[37] R. Palmiter,et al. Multiple pathways involved in the biosynthesis of anandamide , 2008, Neuropharmacology.
[38] K. Yamamura,et al. Elevated mature macrophage expression of human ABHD2 gene in vulnerable plaque. , 2008, Biochemical and biophysical research communications.
[39] B. Cravatt,et al. A Comprehensive Profile of Brain Enzymes that Hydrolyze the Endocannabinoid 2‐Arachidonoylglycerol , 2007, Chemistry & biology.
[40] M. Lagarde,et al. De novo biosynthesis of the late endosome lipid, bis(monoacylglycero)phosphates⃞ Published, JLR Papers in Press, June 8, 2007. , 2007, Journal of Lipid Research.
[41] B. Cravatt,et al. A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases. , 2007, Journal of the American Chemical Society.
[42] Petra C. Kienesberger,et al. Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome. , 2006, Cell metabolism.
[43] David J Beech,et al. Sensing of Lysophospholipids by TRPC5 Calcium Channel* , 2006, Journal of Biological Chemistry.
[44] K. Mackie,et al. Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. , 2005, The Journal of clinical investigation.
[45] M. Graham,et al. An apolipoprotein B antisense oligonucleotide lowers LDL cholesterol in hyperlipidemic mice without causing hepatic steatosis Published, JLR Papers in Press, February 16, 2005. DOI 10.1194/jlr.M400492-JLR200 , 2005, Journal of Lipid Research.
[46] T. Suda,et al. Increase of smooth muscle cell migration and of intimal hyperplasia in mice lacking the α/β hydrolase domain containing 2 gene , 2005 .
[47] Takao Shimizu,et al. G2A Is a Proton-sensing G-protein-coupled Receptor Antagonized by Lysophosphatidylcholine* , 2004, Journal of Biological Chemistry.
[48] P. Tso,et al. A novel, noninvasive method for the measurement of intestinal fat absorption. , 2004, Gastroenterology.
[49] Rafael A Irizarry,et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. , 2003, Biostatistics.
[50] J. Weissenbach,et al. Mutations in CGI-58, the gene encoding a new protein of the esterase/lipase/thioesterase subfamily, in Chanarin-Dorfman syndrome. , 2001, American journal of human genetics.
[51] N. Nagan,et al. Plasmalogens: biosynthesis and functions. , 2001, Progress in lipid research.
[52] M. Nardini,et al. α/β Hydrolase fold enzymes : the family keeps growing , 1999 .
[53] R. Coleman,et al. Neutral lipid storage disease with fatty liver and cholestasis. , 1997, Journal of pediatric gastroenterology and nutrition.
[54] R. Hammer,et al. Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. , 1996, The Journal of clinical investigation.
[55] W. J. Dyer,et al. A rapid method of total lipid extraction and purification. , 1959, Canadian journal of biochemistry and physiology.
[56] H. Callender,et al. Quantification of diacylglycerol species from cellular extracts by electrospray ionization mass spectrometry using a linear regression algorithm. , 2007, Analytical chemistry.
[57] H. Brown,et al. Glycerophospholipid identification and quantitation by electrospray ionization mass spectrometry. , 2007, Methods in enzymology.
[58] T. Suda,et al. Increase of smooth muscle cell migration and of intimal hyperplasia in mice lacking the alpha/beta hydrolase domain containing 2 gene. , 2005, Biochemical and biophysical research communications.
[59] Thierry Hotelier,et al. ESTHER, the database of the alpha/beta-hydrolase fold superfamily of proteins. , 2004, Nucleic acids research.
[60] S. Mandrup,et al. Conjugated linoleic acid (CLA) induces human adipocyte delipidation: autocrine/paracrine regulation of MEK/ERK signaling by adipocytokines , 2004 .
[61] M. Nardini,et al. Alpha/beta hydrolase fold enzymes: the family keeps growing. , 1999, Current opinion in structural biology.
[62] S. Crooke. Advances in understanding the pharmacological properties of antisense oligonucleotides. , 1997, Advances in pharmacology.
[63] S. Grundy,et al. Method to measure apolipoprotein B-48 and B-100 secretion rates in an individual mouse: evidence for a very rapid turnover of VLDL and preferential removal of B-48- relative to B-100-containing lipoproteins. , 1996, Journal of lipid research.