Nicotine' actions on energy balance: Friend or foe?

[1]  D. Aschenbrenner New Indication for Cancer-Fighting Drug. , 2020, The American journal of nursing.

[2]  T. Sakurai,et al.  Evolution of Orexin Neuropeptide System: Structure and Function , 2020, Frontiers in Neuroscience.

[3]  L. de Lecea,et al.  Editorial: Hypocretins/Orexins , 2020, Frontiers in Endocrinology.

[4]  D. Aschenbrenner FDA Requests Withdrawal of Weight-Loss Drug From Market. , 2020, The American journal of nursing.

[5]  Y. Miki,et al.  Secreted Phospholipase PLA2G2D Contributes to Metabolic Health by Mobilizing ω3 Polyunsaturated Fatty Acids in WAT. , 2020, Cell reports.

[6]  J. Fernø,et al.  Recent Updates on Obesity Treatments: Available Drugs and Future Directions , 2020, Neuroscience.

[7]  M. Evans,et al.  Drug Therapy in Obesity: A Review of Current and Emerging Treatments , 2020, Diabetes Therapy.

[8]  K. Alzoubi,et al.  Comparison of the cardiac effects of electronic cigarette aerosol exposure with waterpipe and combustible cigarette smoke exposure in rats. , 2020, Life sciences.

[9]  K. Schramm,et al.  Pharmacological targeting of α3β4 nicotinic receptors improves peripheral insulin sensitivity in mice with diet-induced obesity , 2020, Diabetologia.

[10]  C. Biasin,et al.  The FODRAT study (FOod addiction, DRugs, Alcohol and Tobacco): first data on food addiction prevalence among patients with addiction to drugs, tobacco and alcohol , 2020, Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity.

[11]  C. Boushey,et al.  Body esteem, weight control outcome expectancies, and e-cigarette use among young adults. , 2020, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[12]  Miguel López,et al.  Orexins/Hypocretins: Key Regulators of Energy Homeostasis , 2019, Front. Endocrinol..

[13]  M. Huising,et al.  Integrating the inputs that shape pancreatic islet hormone release , 2019, Nature Metabolism.

[14]  Alan Morris Linking nicotine addiction and T2DM , 2019, Nature Reviews Endocrinology.

[15]  M. Torsoni,et al.  JAK2/STAT3 Pathway is Required for α7nAChR-Dependent Expression of POMC and AGRP Neuropeptides in Male Mice. , 2019, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.

[16]  S. Diano,et al.  Brain-to-pancreas signalling axis links nicotine and diabetes , 2019, Nature.

[17]  M. Rafraf,et al.  Effectiveness of Genistein Supplementation on Metabolic Factors and Antioxidant Status in Postmenopausal Women With Type 2 Diabetes Mellitus. , 2019, Canadian journal of diabetes.

[18]  Samuel C Funderburk,et al.  MCH Regulates SIRT1/FoxO1 and Reduces POMC Neuronal Activity to Induce Hyperphagia, Adiposity, and Glucose Intolerance , 2019, Diabetes.

[19]  Avi Ma’ayan,et al.  Habenular Tcf7l2 links nicotine addiction to diabetes , 2019, Nature.

[20]  K. Sakimura,et al.  Differential Roles of Each Orexin Receptor Signaling in Obesity , 2019, iScience.

[21]  Ana I. Domingos,et al.  Central nicotine induces browning through hypothalamic κ opioid receptor , 2019, Nature Communications.

[22]  J. Wess,et al.  Allosteric modulation of β-cell M3 muscarinic acetylcholine receptors greatly improves glucose homeostasis in lean and obese mice , 2019, Proceedings of the National Academy of Sciences.

[23]  Lawrence M. Lifshitz,et al.  Diverse repertoire of human adipocyte subtypes develops from transcriptionally distinct mesenchymal progenitor cells , 2019, Proceedings of the National Academy of Sciences.

[24]  E. Valjent,et al.  Hypothalamic dopamine signalling regulates brown fat thermogenesis , 2019, Nature Metabolism.

[25]  J. Fernø,et al.  Glucagon Control on Food Intake and Energy Balance , 2019, International journal of molecular sciences.

[26]  Wei Zhang,et al.  Four-week administration of nicotinemoderately impacts blood metabolic profile and gut microbiota in a diet-dependent manner. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[27]  A. Carvalho,et al.  Effects of different pharmacologic smoking cessation treatments on body weight changes and success rates in patients with nicotine dependence: A network meta‐analysis , 2019, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[28]  Alexander M. Herman,et al.  Sensory perception drives food avoidance through excitatory basal forebrain circuits , 2019, eLife.

[29]  P. Cheng,et al.  Genistein ameliorated obesity accompanied with adipose tissue browning and attenuation of hepatic lipogenesis in ovariectomized rats with high-fat diet. , 2019, The Journal of nutritional biochemistry.

[30]  C. Bullen,et al.  Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation. , 2019, The Cochrane database of systematic reviews.

[31]  Benjamin R. Arenkiel,et al.  A lateral hypothalamus to basal forebrain neurocircuit promotes feeding by suppressing responses to anxiogenic environmental cues , 2019, Science Advances.

[32]  M. Blüher Obesity: global epidemiology and pathogenesis , 2019, Nature Reviews Endocrinology.

[33]  O. Contreras-Rodríguez,et al.  Hypothalamic Networks in Adolescents With Excess Weight: Stress-Related Connectivity and Associations With Emotional Eating. , 2019, Journal of the American Academy of Child and Adolescent Psychiatry.

[34]  Sunil K. Panigrahi,et al.  Effects of Naltrexone on Energy Balance and Hypothalamic Melanocortin Peptides in Male Mice Fed a High-Fat Diet , 2019, Journal of the Endocrine Society.

[35]  S. Sagarkar,et al.  Neuropeptide CART prevents memory loss attributed to withdrawal of nicotine following chronic treatment in mice , 2019, Addiction biology.

[36]  J. Leahy,et al.  β-Cell mass restoration by α7 nicotinic acetylcholine receptor activation , 2018, The Journal of Biological Chemistry.

[37]  T. Quesada-López,et al.  CXCL14, a Brown Adipokine that Mediates Brown-Fat-to-Macrophage Communication in Thermogenic Adaptation. , 2018, Cell metabolism.

[38]  A. Feuchtinger,et al.  Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes , 2018, Nature Communications.

[39]  M. Tschöp,et al.  Emerging hormonal-based combination pharmacotherapies for the treatment of metabolic diseases , 2018, Nature Reviews Endocrinology.

[40]  G. Shulman,et al.  Mechanisms of Insulin Action and Insulin Resistance. , 2018, Physiological reviews.

[41]  A. Coll,et al.  POMC: The Physiological Power of Hormone Processing. , 2018, Physiological reviews.

[42]  Michael Fang Association between adolescent body-mass index and adulthood smoking. , 2018, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[43]  N. Talley,et al.  Influence of cigarette smoking on the human duodenal mucosa-associated microbiota , 2018, Microbiome.

[44]  A. Terry,et al.  Nicotinic Acetylcholine Receptor Ligands, Cognitive Function, and Preclinical Approaches to Drug Discovery , 2018, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[45]  Korey P. Wylie,et al.  Alpha7 Nicotinic Receptors as Therapeutic Targets in Schizophrenia. , 2018, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[46]  M. Tschöp,et al.  Anti-Obesity Therapy: from Rainbow Pills to Polyagonists , 2018, Pharmacological Reviews.

[47]  R. Knight,et al.  Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism , 2018, Nature Communications.

[48]  C. Diéguez,et al.  Genetic Targeting of GRP78 in the VMH Improves Obesity Independently of Food Intake , 2018, Genes.

[49]  B. Kieffer,et al.  Opioid receptors: drivers to addiction? , 2018, Nature Reviews Neuroscience.

[50]  Y. Mineur,et al.  Molecular and cellular characterization of nicotinic acetylcholine receptor subtypes in the arcuate nucleus of the mouse hypothalamus , 2018, The European journal of neuroscience.

[51]  Huijie Li,et al.  Varenicline is associated with a modest limitation in weight gain in smokers after smoking cessation: a meta-analysis , 2018, Journal of public health.

[52]  C. Bullen,et al.  Nicotine replacement therapy versus control for smoking cessation. , 2018, The Cochrane database of systematic reviews.

[53]  P. Brennan,et al.  Role of obesity in smoking behaviour: Mendelian randomisation study in UK Biobank , 2018, British Medical Journal.

[54]  M. Munafo,et al.  The effect of body mass index on smoking behaviour and nicotine metabolism: a Mendelian randomization study , 2018, bioRxiv.

[55]  J. Holst,et al.  Effects of Smoking Versus Nonsmoking on Postprandial Glucose Metabolism in Heavy Smokers Compared With Nonsmokers , 2018, Diabetes Care.

[56]  R. Maldonado,et al.  Melanin-Concentrating Hormone acts through hypothalamic kappa opioid system and p70S6K to stimulate acute food intake , 2018, Neuropharmacology.

[57]  X. Z. S. Xu,et al.  An immune-beige adipocyte communication via nicotinic acetylcholine receptor signaling , 2018, Nature Medicine.

[58]  J. Latorre,et al.  Gut Microbiota Interacts with Markers of Adipose Tissue Browning, Insulin Action and Plasma Acetate in Morbid Obesity , 2018, Molecular nutrition & food research.

[59]  Mark A. Rossi,et al.  Overlapping Brain Circuits for Homeostatic and Hedonic Feeding. , 2018, Cell metabolism.

[60]  B. Cannon,et al.  What Ignites UCP1? , 2017, Cell metabolism.

[61]  Ana I. Domingos,et al.  Sympathetic neuron–associated macrophages contribute to obesity by importing and metabolizing norepinephrine , 2017, Nature Medicine.

[62]  K. Lutfy,et al.  Effects of nicotine on homeostatic and hedonic components of food intake. , 2017, The Journal of endocrinology.

[63]  L. V. Van Gaal,et al.  Do E‐cigarettes induce weight changes and increase cardiometabolic risk? A signal for the future , 2017, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[64]  M. Picciotto,et al.  Access to nicotine in drinking water reduces weight gain without changing caloric intake on high fat diet in male C57BL/6J mice , 2017, Neuropharmacology.

[65]  Sen Song,et al.  Somatostatin Neurons in the Basal Forebrain Promote High-Calorie Food Intake. , 2017, Cell reports.

[66]  F. Villarroya,et al.  Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance , 2017, Cell metabolism.

[67]  H. Nagaraja,et al.  A tale of two risks: smoking, diabetes and the subgingival microbiome , 2017, The ISME Journal.

[68]  J. Brüning,et al.  Neuronal control of peripheral insulin sensitivity and glucose metabolism , 2017, Nature Communications.

[69]  O. Contreras-Rodríguez,et al.  Ventral and Dorsal Striatum Networks in Obesity: Link to Food Craving and Weight Gain , 2017, Biological Psychiatry.

[70]  H. I. Lanza,et al.  Obesity and Cigarette Smoking: Extending the Link to E-cigarette/Vaping Use. , 2017, American journal of health behavior.

[71]  L. M. Williams,et al.  Central Regulation of Glucose Homeostasis. , 2017, Comprehensive Physiology.

[72]  P. Westgate,et al.  Mast Cells Promote Seasonal White Adipose Beiging in Humans , 2017, Diabetes.

[73]  J. Gornbein,et al.  Increased Cardiac Sympathetic Activity and Oxidative Stress in Habitual Electronic Cigarette Users: Implications for Cardiovascular Risk , 2017, JAMA cardiology.

[74]  M. Tschöp,et al.  Current Understanding of the Hypothalamic Ghrelin Pathways Inducing Appetite and Adiposity , 2017, Trends in Neurosciences.

[75]  K. Rahmouni,et al.  The cellular and molecular bases of leptin and ghrelin resistance in obesity , 2017, Nature Reviews Endocrinology.

[76]  K. Fujioka,et al.  Method‐of‐use study of naltrexone sustained release (SR)/bupropion SR on body weight in individuals with obesity , 2016, Obesity.

[77]  J. Moreno-Navarrete,et al.  Thyroid hormones induce browning of white fat , 2016, The Journal of endocrinology.

[78]  N. Avena,et al.  The neurobiological and behavioral overlaps of nicotine and food addiction. , 2016, Preventive medicine.

[79]  Alexander M. Herman,et al.  A cholinergic basal forebrain feeding circuit modulates appetite suppression , 2016, Nature.

[80]  Wei-Cheng Chang,et al.  Cell type-specific long-range connections of basal forebrain circuit , 2016, eLife.

[81]  N. Casals,et al.  Reduction of Hypothalamic Endoplasmic Reticulum Stress Activates Browning of White Fat and Ameliorates Obesity , 2016, Diabetes.

[82]  J. Fernø,et al.  Hypothalamic kappa opioid receptor mediates both diet‐induced and melanin concentrating hormone–induced liver damage through inflammation and endoplasmic reticulum stress , 2016, Hepatology.

[83]  F. Greenway,et al.  The relationship between early weight loss and weight loss at 1 year with naltrexone ER/bupropion ER combination therapy , 2016, International Journal of Obesity.

[84]  M. Camilleri,et al.  Association of Pharmacological Treatments for Obesity With Weight Loss and Adverse Events: A Systematic Review and Meta-analysis. , 2016, JAMA.

[85]  G. Labouèbe,et al.  Glucose responsive neurons of the paraventricular thalamus control sucrose-seeking behavior , 2016, Nature Neuroscience.

[86]  K. Fujioka,et al.  Evolution of pharmacological obesity treatments: focus on adverse side‐effect profiles , 2016, Diabetes, obesity & metabolism.

[87]  Antoine Adamantidis,et al.  Awake dynamics and brain-wide direct inputs of hypothalamic MCH and orexin networks , 2016, Nature Communications.

[88]  E. Koylu,et al.  Nicotine regulates cocaine‐amphetamine‐Regulated Transcript (Cart) in the mesocorticolimbic system , 2016, Synapse.

[89]  M. Quik,et al.  Neuronal Nicotinic Acetylcholine Receptor Modulators Reduce Sugar Intake , 2016, PloS one.

[90]  L. Groop,et al.  MafA-Controlled Nicotinic Receptor Expression Is Essential for Insulin Secretion and Is Impaired in Patients with Type 2 Diabetes , 2016, Cell reports.

[91]  F. Reichmann,et al.  Neuropeptide Y: A stressful review , 2016, Neuropeptides.

[92]  J. Fernø,et al.  Orexins (hypocretins) and energy balance: More than feeding , 2015, Molecular and Cellular Endocrinology.

[93]  Nicola Zamboni,et al.  Gut Microbiota Orchestrates Energy Homeostasis during Cold , 2015, Cell.

[94]  T. Horvath,et al.  Neuronal Regulation of Energy Homeostasis: Beyond the Hypothalamus and Feeding. , 2015, Cell metabolism.

[95]  O. Dekkers,et al.  Smoking is associated with increased resting energy expenditure in the general population: The NEO study. , 2015, Metabolism: clinical and experimental.

[96]  Jans H. Alzate-Morales,et al.  Multiple binding sites in the nicotinic acetylcholine receptors: An opportunity for polypharmacolgy. , 2015, Pharmacological research.

[97]  H. Parlakpınar,et al.  Evaluation of the cardiovascular effects of varenicline in rats , 2015, Drug design, development and therapy.

[98]  H. Mansvelder,et al.  Cholinergic modulation of dopamine pathways through nicotinic acetylcholine receptors. , 2015, Biochemical pharmacology.

[99]  D. Colin,et al.  Microbiota depletion promotes browning of white adipose tissue and reduces obesity , 2015, Nature Medicine.

[100]  D. Bertrand,et al.  Therapeutic Potential of α7 Nicotinic Acetylcholine Receptors , 2015, Pharmacological Reviews.

[101]  Tiago Branco,et al.  Cell type-specific transcriptomics of hypothalamic energy-sensing neuron responses to weight-loss , 2015, eLife.

[102]  R. Knight,et al.  The gut microbiota in human energy homeostasis and obesity , 2015, Trends in Endocrinology & Metabolism.

[103]  F. Barrantes,et al.  Nicotinic α4 Receptor-Mediated Cholinergic Influences on Food Intake and Activity Patterns in Hypothalamic Circuits , 2015, PloS one.

[104]  J. Zubieta,et al.  Endogenous Opioid Mechanisms Are Implicated in Obesity and Weight Loss in Humans. , 2015, The Journal of clinical endocrinology and metabolism.

[105]  R. Leis,et al.  Hypothalamic-autonomic control of energy homeostasis , 2015, Endocrine.

[106]  A. Bonci,et al.  Role of Dopamine Neurons in Reward and Aversion: A Synaptic Plasticity Perspective , 2015, Neuron.

[107]  Zhe Zhang,et al.  Cross-talk between α7 nAChR-mediated cholinergic pathway and acylation stimulating protein signaling in 3T3-L1 adipocytes: role of NFκB and STAT3. , 2015, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[108]  R. L. Brown,et al.  Hindbrain Catecholamine Neurons Activate Orexin Neurons During Systemic Glucoprivation in Male Rats. , 2015, Endocrinology.

[109]  C. Diéguez,et al.  Come to Where Insulin Resistance Is, Come to AMPK Country. , 2015, Cell metabolism.

[110]  G. Winterer,et al.  Effects of Cigarette Smoking on Plasma Concentration of the Appetite-Regulating Peptide Ghrelin , 2015, Annals of Nutrition and Metabolism.

[111]  J. Pell,et al.  Relationship between Smoking and Obesity: A Cross-Sectional Study of 499,504 Middle-Aged Adults in the UK General Population , 2015, PloS one.

[112]  Minmin Luo,et al.  Whole-brain mapping of the direct inputs and axonal projections of POMC and AgRP neurons , 2015, Front. Neuroanat..

[113]  M. Andermann,et al.  Ghrelin , 2015, Molecular metabolism.

[114]  L. Sidossis,et al.  Genetic and functional characterization of clonally derived adult human brown adipocytes , 2015, Nature Medicine.

[115]  A. Saha,et al.  Pregnancy induces resistance to the anorectic effect of hypothalamic malonyl-CoA and the thermogenic effect of hypothalamic AMPK inhibition in female rats. , 2015, Endocrinology.

[116]  B. Sabatini,et al.  Corelease of acetylcholine and GABA from cholinergic forebrain neurons , 2015, eLife.

[117]  M. R. White,et al.  Smoking cessation and improvement in physical performance among young men. , 2015, Military medicine.

[118]  B. Viollet,et al.  Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo , 2015, Nature Medicine.

[119]  M. Picciotto,et al.  Acetylcholine Acts through Nicotinic Receptors to Enhance the Firing Rate of a Subset of Hypocretin Neurons in the Mouse Hypothalamus through Distinct Presynaptic and Postsynaptic Mechanisms, , 2015, eNeuro.

[120]  J. Monti,et al.  Increased REM sleep after intra-locus coeruleus nucleus microinjection of melanin-concentrating hormone (MCH) in the rat , 2015, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[121]  Jonathan R. Brestoff,et al.  Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity , 2014, Nature.

[122]  S. Herpertz,et al.  Impaired Cross-Talk between Mesolimbic Food Reward Processing and Metabolic Signaling Predicts Body Mass Index , 2014, Front. Behav. Neurosci..

[123]  Takeshi Sakurai,et al.  The role of orexin in motivated behaviours , 2014, Nature Reviews Neuroscience.

[124]  C. Collins,et al.  The Prevalence of Food Addiction as Assessed by the Yale Food Addiction Scale: A Systematic Review , 2014, Nutrients.

[125]  B. Cannon,et al.  The browning of white adipose tissue: some burning issues. , 2014, Cell metabolism.

[126]  B. Levin,et al.  Perifornical Hypothalamic Orexin and Serotonin Modulate the Counterregulatory Response to Hypoglycemic and Glucoprivic Stimuli , 2014, Diabetes.

[127]  Sonal Singh,et al.  Varenicline and cardiovascular adverse events: a perspective review , 2014, Therapeutic advances in drug safety.

[128]  D. O'Connor,et al.  Nicotinic acetylcholine receptors in glucose homeostasis: the acute hyperglycemic and chronic insulin-sensitive effects of nicotine suggest dual opposing roles of the receptors in male mice. , 2014, Endocrinology.

[129]  A. Kalsbeek,et al.  Estradiol Regulates Brown Adipose Tissue Thermogenesis via Hypothalamic AMPK , 2014, Cell metabolism.

[130]  Hidemi Ito,et al.  Varenicline is more effective in attenuating weight gain than nicotine patch 12 months after the end of smoking cessation therapy: an observational study in Japan. , 2014, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[131]  N. Kiguchi,et al.  Nicotine effects and the endogenous opioid system. , 2014, Journal of pharmacological sciences.

[132]  K. Rahmouni,et al.  The brain and brown fat , 2014, Annals of medicine.

[133]  F. Villarroya,et al.  GLP-1 Agonism Stimulates Brown Adipose Tissue Thermogenesis and Browning Through Hypothalamic AMPK , 2014, Diabetes.

[134]  A. Verberne,et al.  Orexinergic Activation of Medullary Premotor Neurons Modulates the Adrenal Sympathoexcitation to Hypothalamic Glucoprivation , 2014, Diabetes.

[135]  Michael L. Johnson,et al.  Comparative Effectiveness of Smoking Cessation Medications to Attenuate Weight Gain Following Cessation , 2014, Substance use & misuse.

[136]  V. Bondarenko,et al.  NMR structures of the human α7 nAChR transmembrane domain and associated anesthetic binding sites. , 2014, Biochimica et biophysica acta.

[137]  S. Ostlund,et al.  Differential Effects of Systemic Cholinergic Receptor Blockade on Pavlovian Incentive Motivation and Goal-Directed Action Selection , 2014, Neuropsychopharmacology.

[138]  C. Schaaf Nicotinic acetylcholine receptors in human genetic disease , 2014, Genetics in Medicine.

[139]  P. B. Martinez de Morentin,et al.  Nicotine improves obesity and hepatic steatosis and ER stress in diet-induced obese male rats. , 2014, Endocrinology.

[140]  G. Pacini,et al.  Effects of smoking cessation on β-cell function, insulin sensitivity, body weight, and appetite. , 2014, European journal of endocrinology.

[141]  U. Linnenkamp,et al.  Global estimates of diabetes prevalence for 2013 and projections for 2035. , 2014, Diabetes research and clinical practice.

[142]  M. Reitman,et al.  Effect of Intermittent Cold Exposure on Brown Fat Activation, Obesity, and Energy Homeostasis in Mice , 2014, PloS one.

[143]  Kristian Thorlund,et al.  Cardiovascular Events Associated With Smoking Cessation Pharmacotherapies: A Network Meta-Analysis , 2014, Circulation.

[144]  S. Ryter,et al.  A functional link between heme oxygenase-1 and tristetraprolin in the anti-inflammatory effects of nicotine. , 2013, Free radical biology & medicine.

[145]  Robert D Gibbons,et al.  Varenicline, smoking cessation, and neuropsychiatric adverse events. , 2013, The American journal of psychiatry.

[146]  E. Stice,et al.  Relative ability of fat and sugar tastes to activate reward, gustatory, and somatosensory regions. , 2013, The American journal of clinical nutrition.

[147]  V. M. Pickel,et al.  Dopamine D2 and acetylcholine α7 nicotinic receptors have subcellular distributions favoring mediation of convergent signaling in the mouse ventral tegmental area , 2013, Neuroscience.

[148]  Randy J. Seeley,et al.  Cooperation between brain and islet in glucose homeostasis and diabetes , 2013, Nature.

[149]  J. Kastrup,et al.  Two Distinct Allosteric Binding Sites at α4β2 Nicotinic Acetylcholine Receptors Revealed by NS206 and NS9283 Give Unique Insights to Binding Activity-associated Linkage at Cys-loop Receptors* , 2013, The Journal of Biological Chemistry.

[150]  J. Fadel,et al.  Intravenous prenatal nicotine exposure increases orexin expression in the lateral hypothalamus and orexin innervation of the ventral tegmental area in adult male rats. , 2013, Drug and alcohol dependence.

[151]  Chien Li,et al.  Conditional viral tracing reveals that steroidogenic factor 1‐positive neurons of the dorsomedial subdivision of the ventromedial hypothalamus project to autonomic centers of the hypothalamus and hindbrain , 2013, The Journal of comparative neurology.

[152]  J. Granneman,et al.  Identification of an adipogenic niche for adipose tissue remodeling and restoration. , 2013, Cell metabolism.

[153]  F. Pitta,et al.  Reduction of physical activity in daily life and its determinants in smokers without airflow obstruction , 2013, Respirology.

[154]  Eleftheria Maratos-Flier,et al.  Neurochemical characterization of neurons expressing melanin‐concentrating hormone receptor 1 in the mouse hypothalamus , 2013, The Journal of comparative neurology.

[155]  M. Smolka,et al.  Nicotine Alters Food–Cue Reactivity via Networks Extending From the Hypothalamus , 2013, Neuropsychopharmacology.

[156]  B. Pedersen,et al.  A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans. , 2013, Cell metabolism.

[157]  Yun-Hee Choi,et al.  Revisiting the Ventral Medial Nucleus of the Hypothalamus: The Roles of SF-1 Neurons in Energy Homeostasis , 2013, Front. Neurosci..

[158]  F. Villarroya,et al.  Beyond the sympathetic tone: the new brown fat activators. , 2013, Cell metabolism.

[159]  J. Pell,et al.  Impact of smoking and smoking cessation on overweight and obesity: Scotland-wide, cross-sectional study on 40,036 participants , 2013, BMC Public Health.

[160]  S. Sine,et al.  Stoichiometry for drug potentiation of a pentameric ion channel , 2013, Proceedings of the National Academy of Sciences.

[161]  J. Changeux,et al.  Adenosine A2A receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation , 2013, Molecular Psychiatry.

[162]  K. Rahmouni,et al.  Involvement of Hypothalamic AMP-Activated Protein Kinase in Leptin-Induced Sympathetic Nerve Activation , 2013, PloS one.

[163]  K. Rahmouni,et al.  Neuroanatomical determinants of the sympathetic nerve responses evoked by leptin , 2013, Clinical Autonomic Research.

[164]  Jonathan B. Cohen,et al.  Physostigmine and Galanthamine Bind in the Presence of Agonist at the Canonical and Noncanonical Subunit Interfaces of a Nicotinic Acetylcholine Receptor , 2013, The Journal of Neuroscience.

[165]  B. Viollet,et al.  Chronic Exposure to Nicotine Enhances Insulin Sensitivity through α7 Nicotinic Acetylcholine Receptor-STAT3 Pathway , 2012, PloS one.

[166]  R. Eckel,et al.  Novel and Reversible Mechanisms of Smoking-Induced Insulin Resistance in Humans , 2012, Diabetes.

[167]  M. Picciotto,et al.  Nicotinic regulation of energy homeostasis. , 2012, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[168]  D. Bertrand,et al.  Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines , 2012, Proceedings of the National Academy of Sciences.

[169]  M. White,et al.  Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2 , 2012, Diabetologia.

[170]  B. Spiegelman,et al.  Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human , 2012, Cell.

[171]  P. Aveyard,et al.  Weight gain in smokers after quitting cigarettes: meta-analysis , 2012, BMJ : British Medical Journal.

[172]  S. Yakout,et al.  Plasma neuropeptide Y levels relate cigarette smoking and smoking cessation to body weight regulation , 2012, Regulatory Peptides.

[173]  F. Villarroya,et al.  BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions , 2012, Cell.

[174]  A. Bruijnzeel Tobacco addiction and the dysregulation of brain stress systems , 2012, Neuroscience & Biobehavioral Reviews.

[175]  M. J. Vazquez,et al.  The Opioid System and Food Intake: Homeostatic and Hedonic Mechanisms , 2012, Obesity Facts.

[176]  P. B. Martinez de Morentin,et al.  Nicotine Induces Negative Energy Balance Through Hypothalamic AMP-Activated Protein Kinase , 2012, Diabetes.

[177]  L. Nummenmaa,et al.  Dorsal Striatum and Its Limbic Connectivity Mediate Abnormal Anticipatory Reward Processing in Obesity , 2012, PloS one.

[178]  S. Maestrini,et al.  The nicotinic acetylcholine receptor α7 in subcutaneous mature adipocytes: downregulation in human obesity and modulation by diet-induced weight loss , 2012, International Journal of Obesity.

[179]  D. Sikder,et al.  Orexin receptor-1 mediates brown fat developmental differentiation , 2012, Adipocyte.

[180]  M. Karnani,et al.  Activation of Central Orexin/Hypocretin Neurons by Dietary Amino Acids , 2011, Neuron.

[181]  S. Morrison,et al.  An orexinergic projection from perifornical hypothalamus to raphe pallidus increases rat brown adipose tissue thermogenesis , 2011, The Journal of Neuroscience.

[182]  J. Elmquist,et al.  Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction. , 2011, Cell metabolism.

[183]  D. Sikder,et al.  Orexin is required for brown adipose tissue development, differentiation, and function. , 2011, Cell metabolism.

[184]  E. Bullmore,et al.  Neuropsychiatric Adverse Effects of Centrally Acting Antiobesity Drugs , 2011, CNS neuroscience & therapeutics.

[185]  M. Javors,et al.  Serum NPY and BNDF response to a behavioral stressor in alcohol-dependent and healthy control participants , 2011, Psychopharmacology.

[186]  Camillo Ricordi,et al.  Innervation patterns of autonomic axons in the human endocrine pancreas. , 2011, Cell metabolism.

[187]  N. Benowitz,et al.  Cigarette Smoking, Nicotine, and Body Weight , 2011, Clinical pharmacology and therapeutics.

[188]  Y. Mineur,et al.  Nicotine Decreases Food Intake Through Activation of POMC Neurons , 2011, Science.

[189]  A. N. van den Pol,et al.  Nicotine excites hypothalamic arcuate anorexigenic proopiomelanocortin neurons and orexigenic neuropeptide Y neurons: similarities and differences. , 2011, Journal of neurophysiology.

[190]  J. Elmquist,et al.  Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus , 2011, Proceedings of the National Academy of Sciences.

[191]  C. Ricordi,et al.  Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming human beta cell function , 2011, Nature Medicine.

[192]  N. Subhedar,et al.  Effect of nicotine on feeding and body weight in rats: Involvement of cocaine- and amphetamine-regulated transcript peptide , 2011, Behavioural Brain Research.

[193]  N. Benowitz,et al.  Treatment of nicotine addiction: present therapeutic options and pipeline developments. , 2011, Trends in pharmacological sciences.

[194]  P. Kenny Reward Mechanisms in Obesity: New Insights and Future Directions , 2011, Neuron.

[195]  Zhenggang Yang,et al.  Activation of the cholinergic antiinflammatory pathway ameliorates obesity-induced inflammation and insulin resistance. , 2011, Endocrinology.

[196]  P. Robledo,et al.  Neurobiological mechanisms involved in nicotine dependence and reward: Participation of the endogenous opioid system , 2010, Neuroscience & Biobehavioral Reviews.

[197]  C. Libert,et al.  Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action. , 2010, Cell metabolism.

[198]  K. Shin,et al.  High fat diet altered the mechanism of energy homeostasis induced by nicotine and withdrawal in C57BL/6 mice , 2010, Molecules and cells.

[199]  Ricardo Lage,et al.  Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance , 2010, Nature Medicine.

[200]  J. Changeux,et al.  Nicotine addiction and nicotinic receptors: lessons from genetically modified mice , 2010, Nature Reviews Neuroscience.

[201]  Y. Tseng,et al.  Cellular bioenergetics as a target for obesity therapy , 2010, Nature Reviews Drug Discovery.

[202]  M. Tena-Sempere,et al.  Cross-talk between orexins (hypocretins) and the neuroendocrine axes (hypothalamic–pituitary axes) , 2010, Frontiers in Neuroendocrinology.

[203]  C. Kahn,et al.  Transplantation of adipose tissue and stem cells: role in metabolism and disease , 2010, Nature Reviews Endocrinology.

[204]  A. Cypess,et al.  Brown fat as a therapy for obesity and diabetes , 2010, Current opinion in endocrinology, diabetes, and obesity.

[205]  R. Maldonado,et al.  Hypocretins Regulate the Anxiogenic-Like Effects of Nicotine and Induce Reinstatement of Nicotine-Seeking Behavior , 2010, The Journal of Neuroscience.

[206]  A. Mazurov,et al.  An α7 Nicotinic Acetylcholine Receptor-Selective Agonist Reduces Weight Gain and Metabolic Changes in a Mouse Model of Diabetes , 2010, Journal of Pharmacology and Experimental Therapeutics.

[207]  A. Bruijnzeel kappa-Opioid receptor signaling and brain reward function , 2009, Brain Research Reviews.

[208]  D. Macneil,et al.  Melanin-concentrating hormone 1-receptor antagonist suppresses body weight gain correlated with high receptor occupancy levels in diet-induced obesity mice. , 2009, European journal of pharmacology.

[209]  N. Subhedar,et al.  Participation of corticotropin-releasing factor type 2 receptors in the acute, chronic and withdrawal actions of nicotine associated with feeding behavior in rats , 2009, Appetite.

[210]  A. Adamantidis,et al.  A role for Melanin-Concentrating Hormone in learning and memory , 2009, Peptides.

[211]  Michele Zoli,et al.  Structural and functional diversity of native brain neuronal nicotinic receptors. , 2009, Biochemical pharmacology.

[212]  Jan Nedergaard,et al.  The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[213]  M. Ford,et al.  The influence of mecamylamine on ethanol and sucrose self-administration , 2009, Neuropharmacology.

[214]  Antoine Taly,et al.  Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system , 2009, Nature Reviews Drug Discovery.

[215]  A. Kalsbeek,et al.  A Major Role for Perifornical Orexin Neurons in the Control of Glucose Metabolism in Rats , 2009, Diabetes.

[216]  R. Eckel,et al.  Intramuscular Lipid Metabolism in the Insulin Resistance of Smoking , 2009, Diabetes.

[217]  N. Dahmen,et al.  Basal metabolic rate in narcoleptic patients. , 2009, Sleep.

[218]  H. Ohata,et al.  Nicotine suppresses energy storage through activation of sympathetic outflow to brown adipose tissue via corticotropin-releasing factor type 1 receptor , 2009, Neuroscience Letters.

[219]  S. Woods,et al.  Direct Control of Peripheral Lipid Deposition by CNS GLP-1 Receptor Signaling Is Mediated by the Sympathetic Nervous System and Blunted in Diet-Induced Obesity , 2009, The Journal of Neuroscience.

[220]  Ai-jun Li,et al.  Simultaneous Silencing of Npy and Dbh Expression in Hindbrain A1/C1 Catecholamine Cells Suppresses Glucoprivic Feeding , 2009, The Journal of Neuroscience.

[221]  T. Sakurai,et al.  Enhanced orexin receptor-2 signaling prevents diet-induced obesity and improves leptin sensitivity. , 2009, Cell metabolism.

[222]  J. Fadel,et al.  Activation of orexin/hypocretin projections to basal forebrain and paraventricular thalamus by acute nicotine , 2008, Brain Research Bulletin.

[223]  P. Kenny,et al.  Insular hypocretin transmission regulates nicotine reward , 2008, Proceedings of the National Academy of Sciences.

[224]  M. Kuhar,et al.  CART peptides: regulators of body weight, reward and other functions , 2008, Nature Reviews Neuroscience.

[225]  K. Reynolds,et al.  Global burden of obesity in 2005 and projections to 2030 , 2008, International Journal of Obesity.

[226]  Ricardo Lage,et al.  Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. , 2008, Cell metabolism.

[227]  F. Paccaud,et al.  Consequences of smoking for body weight, body fat distribution, and insulin resistance. , 2008, The American journal of clinical nutrition.

[228]  Robin Christensen,et al.  Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials , 2007, The Lancet.

[229]  T. Dyhring,et al.  A-366833: a novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]-heptane alpha4beta2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models. , 2007, Biochemical pharmacology.

[230]  M. Zoli,et al.  Heterogeneity and complexity of native brain nicotinic receptors. , 2007, Biochemical pharmacology.

[231]  Jason U Tilan,et al.  Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome , 2007, Nature Medicine.

[232]  S. Nishino Clinical and neurobiological aspects of narcolepsy. , 2007, Sleep medicine.

[233]  J. Changeux,et al.  Catecholamine outflow from mouse and rat brain slice preparations evoked by nicotinic acetylcholine receptor activation and electrical field stimulation , 2007, British journal of pharmacology.

[234]  N. Katsilambros,et al.  Differentiation in the short- and long-term effects of smoking on plasma total ghrelin concentrations between male nonsmokers and habitual smokers. , 2007, Metabolism: clinical and experimental.

[235]  D. Pfaff,et al.  Silencing of estrogen receptor α in the ventromedial nucleus of hypothalamus leads to metabolic syndrome , 2007, Proceedings of the National Academy of Sciences.

[236]  P. Kramer,et al.  Nicotine administration effects on feeding and cocaine–amphetamine-regulated transcript (CART) expression in the hypothalamus , 2007, Regulatory Peptides.

[237]  D. Hatsukami,et al.  Effects of high dose transdermal nicotine replacement in cigarette smokers , 2007, Pharmacology Biochemistry and Behavior.

[238]  M. Picciotto,et al.  Nicotine withdrawal increases body weight, neuropeptide Y and Agouti-related protein expression in the hypothalamus and decreases uncoupling protein-3 expression in the brown adipose tissue in high-fat fed mice , 2007, Neuroscience Letters.

[239]  I. Gritti,et al.  Stereological estimates of the basal forebrain cell population in the rat, including neurons containing choline acetyltransferase, glutamic acid decarboxylase or phosphate-activated glutaminase and colocalizing vesicular glutamate transporters , 2006, Neuroscience.

[240]  P. Henny,et al.  Innervation of orexin/hypocretin neurons by GABAergic, glutamatergic or cholinergic basal forebrain terminals evidenced by immunostaining for presynaptic vesicular transporter and postsynaptic scaffolding proteins , 2006, The Journal of comparative neurology.

[241]  F. Ivy Carroll,et al.  Varenicline Is a Partial Agonist at α4β2 and a Full Agonist at α7 Neuronal Nicotinic Receptors , 2006, Molecular Pharmacology.

[242]  M. Zoli,et al.  Brain nicotinic acetylcholine receptors: native subtypes and their relevance. , 2006, Trends in pharmacological sciences.

[243]  Svetlana I. Chefer,et al.  Cigarette Smoking Saturates Brain α4β2 Nicotinic Acetylcholine Receptors , 2006 .

[244]  Ai-jun Li,et al.  Differential responsiveness of dopamine-beta-hydroxylase gene expression to glucoprivation in different catecholamine cell groups. , 2006, Endocrinology.

[245]  Takeshi Sakurai,et al.  Orexin neuron-mediated skeletal muscle vasodilation and shift of baroreflex during defense response in mice. , 2006, American journal of physiology. Regulatory, integrative and comparative physiology.

[246]  J. Wess,et al.  A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo. , 2006, Cell metabolism.

[247]  M. Morris,et al.  Cigarette smoke exposure reprograms the hypothalamic neuropeptide Y axis to promote weight loss. , 2006, American journal of respiratory and critical care medicine.

[248]  Carlos Iribarren,et al.  Active and passive smoking and development of glucose intolerance among young adults in a prospective cohort: CARDIA study , 2006, BMJ : British Medical Journal.

[249]  S. Akira,et al.  Role of hepatic STAT3 in brain-insulin action on hepatic glucose production. , 2006, Cell metabolism.

[250]  J. E. Silva,et al.  Thermogenic mechanisms and their hormonal regulation. , 2006, Physiological reviews.

[251]  J. Fadel,et al.  Activation of orexin neurons by acute nicotine. , 2006, European journal of pharmacology.

[252]  H. Fields,et al.  Orexin A in the VTA Is Critical for the Induction of Synaptic Plasticity and Behavioral Sensitization to Cocaine , 2006, Neuron.

[253]  T. Scammell,et al.  Afferents to the orexin neurons of the rat brain , 2006, The Journal of comparative neurology.

[254]  C. Kahn,et al.  From mice to men: insights into the insulin resistance syndromes. , 2006, Annual review of physiology.

[255]  C. Ricordi,et al.  The unique cytoarchitecture of human pancreatic islets has implications for islet cell function , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[256]  C. Gotti,et al.  Brain neuronal nicotinic receptors as new targets for drug discovery. , 2006, Current pharmaceutical design.

[257]  Robert A. McGovern,et al.  Leptin Directly Activates SF1 Neurons in the VMH, and This Action by Leptin Is Required for Normal Body-Weight Homeostasis , 2006, Neuron.

[258]  J. Friedman,et al.  Late-Onset Leanness in Mice with Targeted Ablation of Melanin Concentrating Hormone Neurons , 2006, The Journal of Neuroscience.

[259]  M. Serafin,et al.  Opposite effects of noradrenaline and acetylcholine upon hypocretin/orexin versus melanin concentrating hormone neurons in rat hypothalamic slices , 2005, Neuroscience.

[260]  L. Role,et al.  Cholinergic Modulation of Appetite-Related Synapses in Mouse Lateral Hypothalamic Slice , 2005, The Journal of Neuroscience.

[261]  G. Aston-Jones,et al.  A role for lateral hypothalamic orexin neurons in reward seeking , 2005, Nature.

[262]  A. Orr-Urtreger,et al.  Lower core body temperature and attenuated nicotine-induced hypothermic response in mice lacking the β4 neuronal nicotinic acetylcholine receptor subunit , 2005, Brain Research Bulletin.

[263]  M. Bednarek,et al.  Antiobesity effect of a melanin-concentrating hormone 1 receptor antagonist in diet-induced obese mice. , 2005, Endocrinology.

[264]  J. Jeon,et al.  Mice with MCH ablation resist diet-induced obesity through strain-specific mechanisms. , 2005, American journal of physiology. Regulatory, integrative and comparative physiology.

[265]  J. Yakel,et al.  Desensitization of nicotinic ACh receptors: shaping cholinergic signaling , 2005, Trends in Neurosciences.

[266]  T. Sakurai,et al.  Difference in obesity phenotype between orexin-knockout mice and orexin neuron-deficient mice with same genetic background and environmental conditions , 2005, Neuroscience Letters.

[267]  H. Yoshimatsu,et al.  Dual regulatory effects of orexins on sympathetic nerve activity innervating brown adipose tissue in rats. , 2005, Endocrinology.

[268]  R. Cone Anatomy and regulation of the central melanocortin system , 2005, Nature Neuroscience.

[269]  A. Yamanaka,et al.  Input of Orexin/Hypocretin Neurons Revealed by a Genetically Encoded Tracer in Mice , 2005, Neuron.

[270]  K. Leitzell,et al.  Rapid Upregulation of α7 Nicotinic Acetylcholine Receptors by Tyrosine Dephosphorylation , 2005, The Journal of Neuroscience.

[271]  M. Morris,et al.  Effect of Short-Term Cigarette Smoke Exposure on Body Weight, Appetite and Brain Neuropeptide Y in Mice , 2005, Neuropsychopharmacology.

[272]  E. G. Hill,et al.  Meal patterns in female rats during and after intermittent nicotine administration , 2005, Pharmacology Biochemistry and Behavior.

[273]  Robert M Sears,et al.  The Hypothalamic Neuropeptide Melanin-Concentrating Hormone Acts in the Nucleus Accumbens to Modulate Feeding Behavior and Forced-Swim Performance , 2005, The Journal of Neuroscience.

[274]  D. Burdakov,et al.  Physiological Changes in Glucose Differentially Modulate the Excitability of Hypothalamic Melanin-Concentrating Hormone and Orexin Neurons In Situ , 2005, The Journal of Neuroscience.

[275]  Neal L. Benowitz,et al.  Metabolism and Disposition Kinetics of Nicotine , 2005, Pharmacological Reviews.

[276]  E. Hellström‐Lindahl,et al.  Evidence for functional nicotinic receptors on pancreatic β cells , 2005 .

[277]  S. Leibowitz,et al.  Circulating triglycerides impact on orexigenic peptides and neuronal activity in hypothalamus. , 2004, Endocrinology.

[278]  S. Cragg,et al.  Nicotine amplifies reward-related dopamine signals in striatum , 2004, Nature Neuroscience.

[279]  J. Baron,et al.  Acute effects of nicotine on serum glucose insulin growth hormone and cortisol in healthy smokers. , 2004, Metabolism: clinical and experimental.

[280]  A. Fernández-Cruz,et al.  Smoking cessation and weight gain , 2004, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[281]  Ai-jun Li,et al.  Glucoprivation increases expression of neuropeptide Y mRNA in hindbrain neurons that innervate the hypothalamus , 2004, The European journal of neuroscience.

[282]  S. Krivoshiev,et al.  The effect of smoking on peripheral insulin sensitivity and plasma endothelin level. , 2004, Diabetes & metabolism.

[283]  D. Accili,et al.  Mouse models of insulin resistance. , 2004, American journal of physiology. Endocrinology and metabolism.

[284]  W. Ricart,et al.  Smoking, fat mass and activation of the tumor necrosis factor-α pathway , 2003, International Journal of Obesity.

[285]  H. McRobbie,et al.  Stopping smoking can cause constipation. , 2003, Addiction.

[286]  M. Bednarek,et al.  Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats. , 2003, European journal of pharmacology.

[287]  J. Flier,et al.  Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[288]  Takeshi Sakurai,et al.  Hypothalamic Orexin Neurons Regulate Arousal According to Energy Balance in Mice , 2003, Neuron.

[289]  M. Crocq Alcohol, nicotine, caffeine, and mental disorders , 2003, Dialogues in clinical neuroscience.

[290]  Björn Eliasson,et al.  Cigarette smoking and diabetes. , 2003, Progress in cardiovascular diseases.

[291]  K. Kim,et al.  Nicotine administration decreases neuropeptide Y expression and increases leptin receptor expression in the hypothalamus of food-deprived rats , 2003, Brain Research.

[292]  Michael Esterman,et al.  The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis , 2003, Neuron.

[293]  F. Casanueva,et al.  Agouti-related peptide, neuropeptide Y, and somatostatin-producing neurons are targets for ghrelin actions in the rat hypothalamus. , 2003, Endocrinology.

[294]  A. Cepeda-Benito,et al.  Meal patterns in male rats during and after intermittent nicotine administration , 2003, Pharmacology Biochemistry and Behavior.

[295]  D. Talmage,et al.  Nicotinic receptor-mediated effects on appetite and food intake. , 2002, Journal of neurobiology.

[296]  L. Role,et al.  Cholinergic modulation of purinergic and GABAergic co-transmission at in vitro hypothalamic synapses. , 2002, Journal of neurophysiology.

[297]  H. Hsiung,et al.  Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity. , 2002, Endocrinology.

[298]  D. Coscina,et al.  Nicotine and its withdrawal alter feeding induced by paraventricular hypothalamic injections of neuropeptide Y in Sprague-Dawley rats , 2002, Psychopharmacology.

[299]  M. Picciotto,et al.  Acute and long‐term changes in the mesolimbic dopamine pathway after systemic or local single nicotine injections , 2002, The European journal of neuroscience.

[300]  C. Szabó,et al.  Nicotine reduces the incidence of type I diabetes in mice. , 2002, The Journal of pharmacology and experimental therapeutics.

[301]  Yue Feng,et al.  Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[302]  L. Seoane,et al.  Neuropeptide Y, but Not Agouti-Related Peptide or Melanin-Concentrating Hormone, Is a Target Peptide for Orexin-A Feeding Actions in the Rat Hypothalamus , 2002, Neuroendocrinology.

[303]  Jon T. Willie,et al.  Orexin (Hypocretin) Neurons Contain Dynorphin , 2001, The Journal of Neuroscience.

[304]  D. Bertrand,et al.  Neuronal nicotinic receptors: from structure to function. , 2001, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[305]  P. Arner,et al.  Systemic nicotine stimulates human adipose tissue lipolysis through local cholinergic and catecholaminergic receptors , 2001, International Journal of Obesity.

[306]  F. Leslie,et al.  Expression of the melanin‐concentrating hormone (MCH) receptor mRNA in the rat brain , 2001, The Journal of comparative neurology.

[307]  P. Jansson,et al.  Nicotine infusion acutely impairs insulin sensitivity in type 2 diabetic patients but not in healthy subjects , 2001, Journal of internal medicine.

[308]  E. Calle,et al.  Cigarette smoking and diabetes mellitus: evidence of a positive association from a large prospective cohort study. , 2001, International journal of epidemiology.

[309]  Kyongsong Kim,et al.  Nicotine infusion alters leptin and uncoupling protein 1 mRNA expression in adipose tissues of rats. , 2001, American journal of physiology. Endocrinology and metabolism.

[310]  M. Low,et al.  Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus , 2001, Nature.

[311]  Jon T. Willie,et al.  Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity , 2001, Neuron.

[312]  J. Holst,et al.  The cephalic insulin response to meal ingestion in humans is dependent on both cholinergic and noncholinergic mechanisms and is important for postprandial glycemia. , 2001, Diabetes.

[313]  E. Mignot,et al.  Changes in CSF hypocretin-1 (orexin A) levels in rats across 24 hours and in response to food deprivation , 2001, Neuroreport.

[314]  C. Saper,et al.  Fos Expression in Orexin Neurons Varies with Behavioral State , 2001, The Journal of Neuroscience.

[315]  B. Lowell,et al.  Melanin-concentrating hormone overexpression in transgenic mice leads to obesity and insulin resistance. , 2001, The Journal of clinical investigation.

[316]  S. L. Parker,et al.  Hypothalamic orexin-A binding sites are downregulated by chronic nicotine treatment in the rat , 2001, Neuroscience Letters.

[317]  J. Arch,et al.  A selective orexin-1 receptor antagonist reduces food consumption in male and female rats , 2000, Regulatory Peptides.

[318]  M. Tschöp,et al.  Ghrelin induces adiposity in rodents , 2000, Nature.

[319]  Y. Hurd,et al.  Human cocaine‐ and amphetamine‐regulated transcript (CART) mRNA is highly expressed in limbic‐ and sensory‐related brain regions , 2000 .

[320]  Ming D. Li,et al.  Nicotine administration enhances NPY expression in the rat hypothalamus , 2000, Brain Research.

[321]  F. Casanueva,et al.  Leptin regulation of prepro-orexin and orexin receptor mRNA levels in the hypothalamus. , 2000, Biochemical and biophysical research communications.

[322]  K. Kawahara,et al.  Effects of abstinence from cigarette smoking on the cardiorespiratory capacity. , 2000, Medicine and science in sports and exercise.

[323]  R. West,et al.  Randomized comparative trial of nicotine polacrilex, a transdermal patch, nasal spray, and an inhaler. , 1999, Archives of internal medicine.

[324]  M. G. Dube,et al.  Food intake elicited by central administration of orexins/hypocretins: identification of hypothalamic sites of action 1 This study was presented in part at the 28th Annual Meeting of the Society for Neuroscience, Los Angeles, CA, in November 1998. 1 , 1999, Brain Research.

[325]  H. Suh,et al.  Central injection of nicotine increases hepatic and splenic interleukin 6 (IL‐6) mRNA expression and plasma IL‐6 levels in mice: involvement of the peripheral sympathetic nervous system , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[326]  K. Kumamoto,et al.  Nicotine induces uncoupling protein 1 in white adipose tissue of obese mice , 1999, International Journal of Obesity.

[327]  Takeshi Sakurai,et al.  Distribution of orexin neurons in the adult rat brain 1 Published on the World Wide Web on 17 March 1999. 1 , 1999, Brain Research.

[328]  T. Sakurai,et al.  Neurons containing orexin in the lateral hypothalamic area of the adult rat brain are activated by insulin-induced acute hypoglycemia , 1999, Neuroscience Letters.

[329]  S. Morrison RVLM and raphe differentially regulate sympathetic outflows to splanchnic and brown adipose tissue. , 1999, American journal of physiology. Regulatory, integrative and comparative physiology.

[330]  A. Levine,et al.  Feeding response to central orexins , 1999, Brain Research.

[331]  S. L. Dun,et al.  Orexin A-like immunoreactivity in the rat brain , 1999, Neuroscience Letters.

[332]  T. Sakurai,et al.  Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[333]  G. Barsh,et al.  Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area , 1998, The Journal of comparative neurology.

[334]  B. Lowell,et al.  Mice lacking melanin-concentrating hormone are hypophagic and lean , 1998, Nature.

[335]  A. N. van den Pol,et al.  Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems , 1998, The Journal of Neuroscience.

[336]  C. Saper,et al.  Leptin Activates Hypothalamic CART Neurons Projecting to the Spinal Cord , 1998, Neuron.

[337]  A. Takahashi,et al.  Stimulation of rat hypothalamus by microdialysis with K+: increase of ACh release elevates plasma glucose. , 1998, American journal of physiology. Regulatory, integrative and comparative physiology.

[338]  D. Vicent,et al.  Functional interactions between melanin-concentrating hormone, neuropeptide Y, and anorectic neuropeptides in the rat hypothalamus. , 1998, Diabetes.

[339]  T. Svensson,et al.  Nicotine and food induced dopamine release in the nucleus accumbens of the rat: Putative role of α7 nicotinic receptors in the ventral tegmental area , 1998, Neuroscience.

[340]  J. Flier,et al.  Melanin-concentrating hormone: a functional melanocortin antagonist in the hypothalamus. , 1998, American journal of physiology. Endocrinology and metabolism.

[341]  S. Carr,et al.  Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior , 1998, Cell.

[342]  A. Sahu Evidence suggesting that galanin (GAL), melanin-concentrating hormone (MCH), neurotensin (NT), proopiomelanocortin (POMC) and neuropeptide Y (NPY) are targets of leptin signaling in the hypothalamus. , 1998, Endocrinology.

[343]  J. Changeux,et al.  Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine , 1998, Nature.

[344]  F E Bloom,et al.  The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[345]  V. Gerzanich,et al.  Chronic Nicotine Exposure Differentially Affects the Function of Human α3, α4, and α7 Neuronal Nicotinic Receptor Subtypes , 1997 .

[346]  T. Hirabayashi,et al.  Neuronal nicotinic acetylcholine receptor in the hypothalamus: morphological diversity and neuroendocrine regulations. , 1997, Brain research. Molecular brain research.

[347]  N. Ling,et al.  Corticotropin-releasing factor-binding protein ligand inhibitor blunts excessive weight gain in genetically obese Zucker rats and rats during nicotine withdrawal. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[348]  B. Steele,et al.  The safety of transdermal nicotine as an aid to smoking cessation in patients with cardiac disease. , 1996, The New England journal of medicine.

[349]  M. Taskinen,et al.  Long-term use of nicotine gum is associated with hyperinsulinemia and insulin resistance. , 1996, Circulation.

[350]  B. Stamford,et al.  Smoking multiple high- versus low-nicotine cigarettes: impact on resting energy expenditure. , 1996, Metabolism: clinical and experimental.

[351]  R. Considine,et al.  Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance , 1996, The Lancet.

[352]  S. Gammeltoft,et al.  A role for melanin-concentrating hormone in the central regulation of feeding behaviour , 1996, Nature.

[353]  R. Considine,et al.  Serum immunoreactive-leptin concentrations in normal-weight and obese humans. , 1996, The New England journal of medicine.

[354]  F. Kraemer,et al.  Alterations of lipolysis and lipoprotein lipase in chronically nicotine-treated rats. , 1996, The American journal of physiology.

[355]  A. Frati,et al.  Acute Effect of Cigarette Smoking on Glucose Tolerance and Other Cardiovascular Risk Factors , 1996, Diabetes Care.

[356]  C. Bing,et al.  Nicotine administration reduces neuropeptide Y and neuropeptide Y mRNA concentrations in the rat hypothalamus: NPY may mediate nicotine's effects on energy balance , 1995, Brain Research.

[357]  L. Sandvik,et al.  Long term effects of smoking on physical fitness and lung function: a longitudinal study of 1393 middle aged Norwegian men for seven years , 1995, BMJ.

[358]  B. Hiremagalur,et al.  Nicotine elicits changes in expression of adrenal catecholamine biosynthetic enzymes, neuropeptide Y and immediate early genes by injection but not continuous administration. , 1995, Brain research. Molecular brain research.

[359]  M. Taskinen,et al.  The insulin resistance syndrome in smokers is related to smoking habits. , 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.

[360]  N. Benowitz,et al.  Establishing a nicotine threshold for addiction. The implications for tobacco regulation. , 1994, The New England journal of medicine.

[361]  N. Sakane,et al.  Effect of nicotine on sympathetic nervous system activity of mice subjected to immobilization stress , 1994, Physiology & Behavior.

[362]  I. Kettelhut,et al.  Intra-ventromedial hypothalamic injection of cholinergic agents induces rapid hyperglycemia, hyperlactatemia and gluconeogenesis activation in fed, conscious rats , 1993, Brain Research.

[363]  S. Shioda,et al.  Immunocytochemical localization of nicotinic acetylcholine receptor in rat hypothalamus , 1993, Brain Research.

[364]  E. Nexo,et al.  Acute effects of smoking during modified sham feeding in duodenal ulcer patients. An analysis of nicotine, acid secretion, gastrin, catecholamines, epidermal growth factor, prostaglandin E2, and bile acids. , 1993, Scandinavian journal of gastroenterology.

[365]  W. J. Thomas,et al.  Feeding responses to perifornical hypothalamic injection of neuropeptide Y in relation to circadian rhythms of eating behavior , 1993, Peptides.

[366]  S. Leibowitz,et al.  The perifornical area: the major focus of (a) patchily distributed hypothalamic neuropeptide Y-sensitive feeding system(s) , 1993, Brain Research.

[367]  T. Conway,et al.  Smoking, exercise, and physical fitness. , 1992, Preventive medicine.

[368]  H. Karten,et al.  Neurons of the chick brain and retina expressing both α-bungarotoxin-sensitive and α-bungarotoxin-insensitive nicotinic acetylcholine receptors: an immunohistochemical analysis , 1992, Brain Research.

[369]  G. Reaven,et al.  Insulin resistance and cigarette smoking , 1992, The Lancet.

[370]  J. Thornhill,et al.  Brown adipose tissue temperature responses following electrical stimulation of ventromedial hypothalamic and lateral preoptic areas or after norepinephrine infusion to long evans or sprague-dawley rats , 1992, Brain Research.

[371]  K. Perkins,et al.  Metabolic effects of cigarette smoking. , 1992, Journal of applied physiology.

[372]  T. Byers,et al.  Smoking cessation and severity of weight gain in a national cohort. , 1991, The New England journal of medicine.

[373]  H. Chase,et al.  Cigarette smoking increases the risk of albuminuria among subjects with type I diabetes. , 1991, JAMA.

[374]  G. Bray,et al.  Effect of corticotropin releasing hormone and neuropeptide Y on electrophysiological activity of sympathetic nerves to interscapular brown adipose tissue , 1990, Neuroscience.

[375]  T. Parkinson,et al.  Luteal inadequacy during the early luteal phase of subfertile cows. , 1990, Journal of reproduction and fertility.

[376]  A. Franco‐Cereceda,et al.  Pharmacology of noradrenaline and neuropeptide tyrosine (NPY)‐mediated sympathetic cotransmission , 1990, Fundamental & clinical pharmacology.

[377]  T. Yoshida,et al.  Effect of nicotine on norepinephrine turnover and thermogenesis in brown adipose tissue and metabolic rate in MSG obese mice. , 1990, Journal of nutritional science and vitaminology.

[378]  L. Epstein,et al.  Perception and hedonics of sweet and fat taste in smokers and nonsmokers following nicotine intake , 1990, Pharmacology Biochemistry and Behavior.

[379]  G. Bray,et al.  Effect of intrahypothalamic hydroxybutyrate on sympathetic firing rate. , 1988, Metabolism: clinical and experimental.

[380]  G. Bray,et al.  Nicotine increases thermogenesis in brown adipose tissue in rats , 1988, Pharmacology Biochemistry and Behavior.

[381]  E. Levin,et al.  Chronic nicotine and withdrawal effects on body weight and food and water consumption in female rats , 1987, Physiology & Behavior.

[382]  Y. Minokoshi,et al.  Ventromedial hypothalamic stimulation accelerates norepinephrine turnover in brown adipose tissue of rats. , 1987, Life sciences.

[383]  D. Albanes,et al.  Associations between smoking and body weight in the US population: analysis of NHANES II. , 1987, American journal of public health.

[384]  H. Wheal,et al.  Hypothalamic control of brown adipose tissue in Zucker lean and obese rats. Effect of electrical stimulation of the ventromedial nucleus and other hypothalamic centres , 1987, Brain Research.

[385]  L. Swanson,et al.  Mapping of brain areas expressing RNA homologous to two different acetylcholine receptor alpha-subunit cDNAs. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[386]  R. Fell,et al.  Effects of smoking cessation on weight gain, metabolic rate, caloric consumption, and blood lipids. , 1986, The American journal of clinical nutrition.

[387]  C. Ninomiya,et al.  Increased frequency of non-insulin-dependent diabetes mellitus among narcoleptic patients. , 1986, Sleep.

[388]  E. Jéquier,et al.  Increased 24-hour energy expenditure in cigarette smokers. , 1986, The New England journal of medicine.

[389]  A. Sollevi,et al.  Frequency- and reserpine-dependent chemical coding of sympathetic transmission: Differential release of noradrenaline and neuropeptide Y from pig spleen , 1986, Neuroscience Letters.

[390]  D. Jacobowitz,et al.  Immunohistochemical localization of a melanin concentrating hormone-like peptide in the rat brain , 1985, Brain Research Bulletin.

[391]  L. Swanson,et al.  Colocalization of neuropeptide Y immunoreactivity in brainstem catecholaminergic neurons that project to the paraventricular nucleus of the hypothalamus , 1985, The Journal of comparative neurology.

[392]  J. E. Hansen,et al.  Immediate effects of cigarette smoking on cardiorespiratory responses to exercise. , 1985, Journal of applied physiology.

[393]  S. C. Feldman,et al.  The somatostatin systems of the guinea-pig brainstem , 1985, Neuroscience.

[394]  G. Bray,et al.  Catecholamine turnover in rats with ventromedial hypothalamic lesions. , 1984, The American journal of physiology.

[395]  D. Niewoehner,et al.  Effects of cigarette smoke and nicotine on feeding and energy , 1984, Physiology & Behavior.

[396]  N. Rothwell,et al.  Activation of brown adipose tissue thermogenesis by the ventromedial hypothalamus , 1981, Nature.

[397]  C. Christiansen,et al.  Influence of Smoking on Insulin Requirement and Metbolic Status in Diabetes Mellitus , 1980, Diabetes Care.

[398]  G. H. Hall,et al.  Hypothermia produced by nicotine perfused through the cerabral ventricles of the unanaesthetized monkey. , 1971, Neuropharmacology.

[399]  E. D. Jacobson,et al.  Effects of nicotine on gastrointestinal secretions.. , 1971, Gastroenterology.

[400]  L. D. Carlson,et al.  Adaptive changes in rats exposed to cold; caloric exchange. , 1954, The American journal of physiology.

[401]  C. Apovian,et al.  Current pharmacotherapy for obesity , 2018, Nature Reviews Endocrinology.

[402]  M. Tschöp,et al.  Current and Emerging Treatment Options in Diabetes Care. , 2016, Handbook of experimental pharmacology.

[403]  H. Nishijo,et al.  Nighttime Administration of Nicotine Improves Hepatic Glucose Metabolism via the Hypothalamic Orexin System in Mice. , 2016, Endocrinology.

[404]  J. Granneman,et al.  Adipogenic role of alternatively activated macrophages in β-adrenergic remodeling of white adipose tissue. , 2016, American journal of physiology. Regulatory, integrative and comparative physiology.

[405]  D. Bertrand,et al.  Nicotinic acetylcholine receptors: from basic science to therapeutics. , 2013, Pharmacology & therapeutics.

[406]  Y. Mineur,et al.  Nicotine, Food Intake, and Activation of POMC Neurons , 2013, Neuropsychopharmacology.

[407]  Y. Jo Endogenous BDNF regulates inhibitory synaptic transmission in the ventromedial nucleus of the hypothalamus. , 2012, Journal of neurophysiology.

[408]  N. Benowitz,et al.  Nicotine chemistry, metabolism, kinetics and biomarkers. , 2009, Handbook of experimental pharmacology.

[409]  D. Balfour The neuronal pathways mediating the behavioral and addictive properties of nicotine. , 2009, Handbook of experimental pharmacology.

[410]  T. Sakurai,et al.  Cholinergic regulation of orexin/hypocretin neurons through M(3) muscarinic receptor in mice. , 2008, Journal of pharmacological sciences.

[411]  W. Wu,et al.  The pharmacological actions of nicotine on the gastrointestinal tract. , 2004, Journal of pharmacological sciences.

[412]  The Wenner-Gren Institute,et al.  Brown adipose tissue: function and physiological significance. , 2004, Physiological reviews.

[413]  S. Matsukura,et al.  Long-term oral nicotine administration reduces insulin resistance in obese rats. , 2003, European journal of pharmacology.

[414]  C. L. Chaffer,et al.  The Feeding Response to Melanin-Concentrating Hormone Is Attenuated by Antagonism of the NPY Y1-Receptor in the Rat. , 2002, Endocrinology.

[415]  S. Matsukura,et al.  Oral nicotine administration decreases tumor necrosis factor-alpha expression in fat tissues in obese rats. , 2001, Metabolism: clinical and experimental.

[416]  V. Gerzanich,et al.  Chronic nicotine exposure differentially affects the function of human alpha3, alpha4, and alpha7 neuronal nicotinic receptor subtypes. , 1997, The Journal of pharmacology and experimental therapeutics.

[417]  C. Bielajew,et al.  Ventromedial hypothalamic regulation of brown adipose tissue. , 1991, Neuroreport.

[418]  K. Ishihara,et al.  Possible involvement of cholinergic nicotinic receptor in insulin release from isolated rat islets. , 1990, Diabetes research and clinical practice.

[419]  D. Bowen,et al.  Effects of chronic nicotine administration on insulin, glucose, epinephrine, and norepinephrine. , 1988, Life sciences.

[420]  K. Fuxe,et al.  Distribution of nicotinic cholinergic receptors in the rat tel- and diencephalon: a quantitative receptor autoradiographical study using [3H]-acetylcholine, [alpha-125I]bungarotoxin and [3H]nicotine. , 1988, Acta physiologica Scandinavica.

[421]  H. Dallosso,et al.  The role of smoking in the regulation of energy balance. , 1984, International journal of obesity.

[422]  D. Topping,et al.  Acute effects of nicotine on plasma free fatty acid concentrations and on the response to cold stress, in lean and obese (genotype ob/ob) mice. , 1979, International journal of obesity.

[423]  M. Frydman,et al.  Brown adipose tissue: the dominant site of nonshivering thermogenesis in the rat. , 1978, Experientia. Supplementum.

[424]  G. Steiner,et al.  Sympathetic ganglia in brown adipose tissue: a new tool to study ganglionic stimulants. , 1972, The American journal of physiology.

[425]  K. Berridge,et al.  Neuroscience and Biobehavioral Reviews Mapping Brain Circuits of Reward and Motivation: in the Footsteps of Ann Kelley , 2022 .

[426]  S. L. Parker,et al.  Printed in U.S.A. Copyright © 2000 by The Endocrine Society Nicotine Up-Regulates Expression of Orexin and Its Receptors in Rat Brain* , 2022 .

[427]  J. Zalvide,et al.  Supplemental Information a Functional Link between Ampk and Orexin Mediates the Effect of Bmp8b on Energy Balance , 2022 .