Insulin Delivery Governed by Covalently Modified Lectin‐Glycogen Gels Sensitive to Glucose

A glucose‐sensitive gel formulation containing concanavalin A and glycogen has been reported previously. Precipitation resulting from the addition of concanavalin A to glycogen has been documented, but the formation of glucose‐sensitive gels based on lectin‐glycogen interactions is novel and used here in our studies. An improved in‐vitro self‐regulating drug‐delivery system, using covalently modified glucose‐sensitive gels based on concanavalin A and a polysaccharide displacement mechanism, is described. The successful use of the covalently modified gels addresses a problem identified previously where significant leaching of the mitogenic lectin from the gel membranes of non‐coupled gels was encountered.

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