An Update on PYRIN Domain-Containing Pattern Recognition Receptors: From Immunity to Pathology
暂无分享,去创建一个
Christian Stehlik | C. Stehlik | R. Ratsimandresy | Rojo A. Ratsimandresy | Andrea Dorfleutner | A. Dorfleutner | Andrea Dorfleutner
[1] B. Lambrecht,et al. Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation. , 2011, Trends in immunology.
[2] E. Kremmer,et al. NLRP10 enhances Shigella‐induced pro‐inflammatory responses , 2012, Cellular microbiology.
[3] A. Henderson. On standard nomenclature. , 1982, Cytogenetics and cell genetics.
[4] G. Wider,et al. NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain. , 2003, Structure.
[5] J. Tschopp,et al. Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1. , 2012, Immunity.
[6] Simon C Watkins,et al. Autocrine activation by interleukin 1alpha induces the fibrogenic phenotype of systemic sclerosis fibroblasts. , 2004, The Journal of rheumatology.
[7] G. Núñez,et al. Cutting Edge: TNF-α Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation1 , 2009, The Journal of Immunology.
[8] M. Hasegawa,et al. Fas-associated factor 1 is a negative regulator of PYRIN-containing Apaf-1-like protein 1. , 2006, International immunology.
[9] A. Godzik,et al. A Novel PAAD-containing Protein That Modulates NF-κB Induction by Cytokines Tumor Necrosis Factor-α and Interleukin-1β* , 2002, The Journal of Biological Chemistry.
[10] C. Stehlik. The PYRIN domain in signal transduction. , 2007, Current protein & peptide science.
[11] J. Ting,et al. Cutting Edge: Monarch-1: A Pyrin/Nucleotide-Binding Domain/Leucine-Rich Repeat Protein That Controls Classical and Nonclassical MHC Class I Genes1 , 2003, The Journal of Immunology.
[12] Richard A. Flavell,et al. The Nalp3 inflammasome is essential for the development of silicosis , 2008, Proceedings of the National Academy of Sciences.
[13] Nan Li,et al. LRRFIP2 negatively regulates NLRP3 inflammasome activation in macrophages by promoting Flightless-I-mediated caspase-1 inhibition , 2013, Nature Communications.
[14] A. Sher,et al. Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction , 2012, Nature Immunology.
[15] S. Leppla,et al. Rapid induction of inflammatory lipid mediators by the inflammasome in vivo , 2012, Nature.
[16] G. Núñez,et al. The Nlrp3 inflammasome is critical for aluminium hydroxide‐mediated IL‐1β secretion but dispensable for adjuvant activity , 2008, European journal of immunology.
[17] J. Tschopp,et al. Caspase-1 Activation of Lipid Metabolic Pathways in Response to Bacterial Pore-Forming Toxins Promotes Cell Survival , 2006, Cell.
[18] J. Bertin,et al. A Functional Role for Nlrp6 in Intestinal Inflammation and Tumorigenesis , 2011, The Journal of Immunology.
[19] John Calvin Reed,et al. Mechanism of Bcl-2 and Bcl-XL inhibition of NLRP1 inflammasome: Loop domain-dependent suppression of ATP binding and oligomerization , 2009, Proceedings of the National Academy of Sciences.
[20] John Calvin Reed,et al. Apoptosis-Associated Speck-Like Protein Containing a Caspase Recruitment Domain Is a Regulator of Procaspase-1 Activation 1 , 2003, The Journal of Immunology.
[21] Monika Schneider,et al. NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses , 2010, The Journal of Immunology.
[22] C. Coban,et al. Silica crystals and aluminum salts regulate the production of prostaglandin in macrophages via NALP3 inflammasome-independent mechanisms. , 2011, Immunity.
[23] Daniel R. Caffrey,et al. AIM2 recognizes cytosolic dsDNA and forms a caspase-1 activating inflammasome with ASC , 2009, Nature.
[24] D. Choubey,et al. IFI16 Protein Mediates the Anti-inflammatory Actions of the Type-I Interferons through Suppression of Activation of Caspase-1 by Inflammasomes , 2011, PloS one.
[25] X. Hua,et al. Analysis of NLRP3 in the Development of Allergic Airway Disease in Mice , 2012, The Journal of Immunology.
[26] J. Bertin,et al. Cutting Edge: NLRP12 Controls Dendritic and Myeloid Cell Migration To Affect Contact Hypersensitivity , 2010, The Journal of Immunology.
[27] P. Vandenabeele,et al. Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling. , 2007, Immunity.
[28] Christine E. Becker,et al. Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes , 2010, Nature Immunology.
[29] Yuzhang Wu,et al. NLRP1 gene polymorphism influences gene transcription and is a risk factor for rheumatoid arthritis in han chinese. , 2012, Arthritis and rheumatism.
[30] V. Dixit,et al. Cryopyrin activates the inflammasome in response to toxins and ATP , 2006, Nature.
[31] R. Germain,et al. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP , 2012, Nature.
[32] S. Leppla,et al. CA-074Me Protection against Anthrax Lethal Toxin , 2009, Infection and Immunity.
[33] J. Tschopp,et al. The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response , 2008, Nature.
[34] K. Moore,et al. The NALP3 inflammasome is involved in the innate immune response to amyloid-β , 2008, Nature Immunology.
[35] B. Becher,et al. RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation , 2011, Nature Immunology.
[36] K. Moore,et al. NLRP3 inflamasomes are required for atherogenesis and activated by cholesterol crystals that form early in disease , 2010, Nature.
[37] F. Martinon,et al. A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses , 2007, Nature Immunology.
[38] P. Vandenabeele,et al. Interferon-β Therapy Against EAE Is Effective Only When Development of the Disease Depends on the NLRP3 Inflammasome , 2012, Science Signaling.
[39] J. Bertin,et al. The NLRP12 inflammasome recognizes Yersinia pestis. , 2012, Immunity.
[40] Xiangmei Zhou,et al. A role for mitochondria in NLRP3 inflammasome activation , 2011, Nature.
[41] Junying Yuan,et al. Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity. , 2013, Molecular cell.
[42] E. Elinav,et al. NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells , 2012, Nature.
[43] J. Cracowski,et al. NLRP1 influences the systemic sclerosis phenotype: a new clue for the contribution of innate immunity in systemic sclerosis-related fibrosing alveolitis pathogenesis , 2010, Annals of the rheumatic diseases.
[44] F. Martinon,et al. NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. , 2004, Immunity.
[45] A. Bowie,et al. Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor. , 2012, Immunity.
[46] D. Anthony,et al. Transient expression of IL-1beta induces acute lung injury and chronic repair leading to pulmonary fibrosis. , 2001, The Journal of clinical investigation.
[47] Juan Pablo Rivero Vaccari,et al. Human astrocytes express a novel NLRP2 inflammasome , 2013, Glia.
[48] G. Dubyak,et al. Differential Requirement of P2X7 Receptor and Intracellular K+ for Caspase-1 Activation Induced by Intracellular and Extracellular Bacteria* , 2007, Journal of Biological Chemistry.
[49] K. Mills,et al. A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis , 2006, The Journal of experimental medicine.
[50] L. French,et al. Inflammasome activation and IL-1β target IL-1α for secretion as opposed to surface expression , 2011, Proceedings of the National Academy of Sciences.
[51] A. Godzik,et al. CARD8 and NLRP1 Undergo Autoproteolytic Processing through a ZU5-Like Domain , 2011, PloS one.
[52] W. Dietrich,et al. Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin , 2006, Nature Genetics.
[53] K. Konaka,et al. PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1. , 2004, International immunology.
[54] F. Sutterwala,et al. TRPM2 links oxidative stress to the NLRP3 inflammasome activation , 2013, Nature Communications.
[55] Paul G. Thomas,et al. Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection , 2013, Nature Immunology.
[56] T. Ichinohe,et al. Encephalomyocarditis Virus Viroporin 2B Activates NLRP3 Inflammasome , 2012, PLoS pathogens.
[57] J. Ather,et al. Mitochondria-targeted drugs enhance Nlrp3 inflammasome-dependent IL-1β secretion in association with alterations in cellular redox and energy status. , 2013, Free radical biology & medicine.
[58] K. J. Henley,et al. NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells. , 2012, Immunity.
[59] J. Bertin,et al. Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF‐κB and caspase‐1 , 2002, FEBS letters.
[60] A. Godzik,et al. A novel PAAD-containing protein that modulates NF-kappa B induction by cytokines tumor necrosis factor-alpha and interleukin-1beta. , 2002, The Journal of biological chemistry.
[61] D. Monack,et al. Type I interferon signaling is required for activation of the inflammasome during Francisella infection , 2007, The Journal of experimental medicine.
[62] R. Schwarzenbacher,et al. Three-dimensional Structure of the NLRP7 Pyrin Domain , 2010, The Journal of Biological Chemistry.
[63] Francis J. Huber,et al. IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine , 2012, Nature.
[64] S. Werner,et al. Active Caspase-1 Is a Regulator of Unconventional Protein Secretion , 2008, Cell.
[65] V. Joag,et al. Proteolytic Processing of Nlrp1b Is Required for Inflammasome Activity , 2012, PLoS pathogens.
[66] R. Ghose,et al. Structure and Dynamics of ASC2, a Pyrin Domain-only Protein That Regulates Inflammatory Signaling* , 2006, Journal of Biological Chemistry.
[67] Richard A. Flavell,et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity , 2012, Nature.
[68] V. Dixit,et al. Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf , 2004, Nature.
[69] Jinfeng Liu,et al. Non-canonical inflammasome activation targets caspase-11 , 2011, Nature.
[70] R. Kolodner,et al. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome , 2001, Nature Genetics.
[71] T. K. van den Berg,et al. Human NLRP3 inflammasome activation is Nox1-4 independent. , 2010, Blood.
[72] C. Stehlik,et al. Inflammasomes and their activation. , 2010, Critical reviews in immunology.
[73] Thomas Lengauer,et al. The HIN domain of IFI-200 proteins consists of two OB folds. , 2005, Biochemical and biophysical research communications.
[74] P. Cresswell,et al. GBP5 Promotes NLRP3 Inflammasome Assembly and Immunity in Mammals , 2012, Science.
[75] M. Seoud,et al. NLRP7, a Nucleotide Oligomerization Domain-like Receptor Protein, Is Required for Normal Cytokine Secretion and Co-localizes with Golgi and the Microtubule-organizing Center* , 2011, The Journal of Biological Chemistry.
[76] A. Bowie,et al. Proteasomal Degradation of Herpes Simplex Virus Capsids in Macrophages Releases DNA to the Cytosol for Recognition by DNA Sensors , 2013, The Journal of Immunology.
[77] Kathleen M. Smith,et al. Development, cytokine profile and function of human interleukin 17–producing helper T cells , 2007, Nature Immunology.
[78] M. Donath,et al. Role of IL-1β in type 2 diabetes , 2010, Current opinion in endocrinology, diabetes, and obesity.
[79] M. Huang,et al. Neisseria gonorrhoeae Activates the Proteinase Cathepsin B to Mediate the Signaling Activities of the NLRP3 and ASC-Containing Inflammasome1 , 2009, The Journal of Immunology.
[80] K. Tracey,et al. Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia , 2010, The Journal of Immunology.
[81] Wei Xu,et al. AIM2 Facilitates the Apoptotic DNA-induced Systemic Lupus Erythematosus via Arbitrating Macrophage Functional Maturation , 2013, Journal of Clinical Immunology.
[82] Egil Lien,et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals , 2010, Nature.
[83] Seth L Masters,et al. Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*). , 2009, Annual review of immunology.
[84] H. H. Park,et al. Crystal Structure of NALP3 Protein Pyrin Domain (PYD) and Its Implications in Inflammasome Assembly* , 2011, The Journal of Biological Chemistry.
[85] B. Lie,et al. A coding polymorphism in NALP1 confers risk for autoimmune Addison's disease and type 1 diabetes , 2009, Genes and Immunity.
[86] S. Landolfo,et al. Role of the Interferon‐Inducible Gene IFI16 in the Etiopathogenesis of Systemic Autoimmune Disorders , 2007, Annals of the New York Academy of Sciences.
[87] Y. Rojanasakul,et al. An NLRP7-containing inflammasome mediates recognition of microbial lipopeptides in human macrophages. , 2012, Immunity.
[88] V. Hornung,et al. Cytosolic DNA Triggers Inflammasome Activation in Keratinocytes in Psoriatic Lesions , 2011, Science Translational Medicine.
[89] P. Mangeot,et al. AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages , 2012, Cell Death and Differentiation.
[90] H. Hammad,et al. An unexpected role for uric acid as an inducer of T helper 2 cell immunity to inhaled antigens and inflammatory mediator of allergic asthma. , 2011, Immunity.
[91] Z. Ye,et al. Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling , 2007, Proceedings of the National Academy of Sciences.
[92] A. Godzik,et al. A Novel Enhancer of the Apaf1 Apoptosome Involved in Cytochrome c-dependent Caspase Activation and Apoptosis* , 2001, The Journal of Biological Chemistry.
[93] Fuping Zhang,et al. A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses. , 2009, Immunity.
[94] A. Doseff,et al. Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization. , 2012, Immunity.
[95] Toshiro Hara,et al. Genetic susceptibility to Kawasaki disease: analysis of pattern recognition receptor genes. , 2012, Human immunology.
[96] John Calvin Reed,et al. The PAAD/PYRIN-Family Protein ASC Is a Dual Regulator of a Conserved Step in Nuclear Factor κB Activation Pathways , 2002, The Journal of experimental medicine.
[97] F. Martinon,et al. Activation of the IL-1beta-processing inflammasome is involved in contact hypersensitivity. , 2007, The Journal of investigative dermatology.
[98] J. Tschopp,et al. Thioredoxin-interacting protein links oxidative stress to inflammasome activation , 2010, Nature Immunology.
[99] Yinyin Li,et al. NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4 , 2012, Nature Immunology.
[100] D. Choubey,et al. Interferon-inducible Ifi200-family genes in systemic lupus erythematosus. , 2008, Immunology letters.
[101] Moshe Arditi,et al. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. , 2012, Immunity.
[102] H. Chi,et al. Inflammasome-Derived IL-1β Regulates the Production of GM-CSF by CD4+ T Cells and γδ T Cells , 2012, The Journal of Immunology.
[103] F. Sutterwala,et al. Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases , 2009, PLoS pathogens.
[104] D. Monack. Faculty Opinions recommendation of Cutting edge: inflammasome activation by alum and alum's adjuvant effect are mediated by NLRP3. , 2008 .
[105] H. Iocca,et al. Cutting Edge: ASC Mediates the Induction of Multiple Cytokines by Porphyromonas gingivalis via Caspase-1-Dependent and -Independent Pathways1 , 2006, The Journal of Immunology.
[106] T. Xiao,et al. Structure of the Absent in Melanoma 2 (AIM2) Pyrin Domain Provides Insights into the Mechanisms of AIM2 Autoinhibition and Inflammasome Assembly* , 2013, The Journal of Biological Chemistry.
[107] S. Leppla,et al. Anthrax Lethal Factor Cleavage of Nlrp1 Is Required for Activation of the Inflammasome , 2012, PLoS pathogens.
[108] P. Vajjhala,et al. Multiple binding sites on the ASC pyrin domain allow self-association and interaction with NLRP 3 , 2012 .
[109] Richard A. Flavell,et al. NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis , 2011, Cell.
[110] R. Flavell,et al. NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy , 2011, Proceedings of the National Academy of Sciences.
[111] H. Hammad,et al. Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome , 2008, The Journal of Immunology.
[112] N. Inohara,et al. ASC-mediated NF-κB Activation Leading to Interleukin-8 Production Requires Caspase-8 and Is Inhibited by CLARP* , 2005, Journal of Biological Chemistry.
[113] B. Arosio,et al. NALP1/NLRP1 Genetic Variants are Associated With Alzheimer Disease , 2012, Alzheimer disease and associated disorders.
[114] D. Choubey,et al. Interferon-inducible p200-family protein IFI16, an innate immune sensor for cytosolic and nuclear double-stranded DNA: regulation of subcellular localization. , 2012, Molecular immunology.
[115] T. Roger,et al. Basic Calcium Phosphate Crystals Induce Monocyte/Macrophage IL-1β Secretion through the NLRP3 Inflammasome In Vitro , 2011, The Journal of Immunology.
[116] Chafen Lu,et al. Nucleotide binding to CARD12 and its role in CARD12-mediated caspase-1 activation. , 2005, Biochemical and biophysical research communications.
[117] K. Fitzgerald,et al. The PYHIN protein family as mediators of host defenses , 2011, Immunological reviews.
[118] J. Bertin,et al. PYPAF7, a Novel PYRIN-containing Apaf1-like Protein That Regulates Activation of NF-κB and Caspase-1-dependent Cytokine Processing* , 2002, The Journal of Biological Chemistry.
[119] V. Dixit,et al. Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis , 2010, Proceedings of the National Academy of Sciences.
[120] G. Dubyak,et al. Pannexin-1 Is Required for ATP Release during Apoptosis but Not for Inflammasome Activation , 2011, The Journal of Immunology.
[121] A. Montpetit,et al. NALP1 Influences Susceptibility to Human Congenital Toxoplasmosis, Proinflammatory Cytokine Response, and Fate of Toxoplasma gondii-Infected Monocytic Cells , 2010, Infection and Immunity.
[122] E. Dahl,et al. The death-domain fold of the ASC PYRIN domain, presenting a basis for PYRIN/PYRIN recognition. , 2003, Journal of molecular biology.
[123] V. Hornung,et al. Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome , 2010, European journal of immunology.
[124] D. Green,et al. The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis. , 2011, Cancer cell.
[125] J. Tschopp,et al. Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica , 2008, Science.
[126] J. Tschopp,et al. Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence , 2009, Nature.
[127] Junying Yuan,et al. Distinct downstream pathways of caspase-11 in regulating apoptosis and cytokine maturation during septic shock response , 2002, Cell Death and Differentiation.
[128] Christian Stehlik,et al. PAN1/NALP2/PYPAF2, an Inducible Inflammatory Mediator That Regulates NF-κB and Caspase-1 Activation in Macrophages* , 2004, Journal of Biological Chemistry.
[129] F. Martinon,et al. Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration , 2007, Cell Death and Differentiation.
[130] Janet M. Young,et al. Extensive evolutionary and functional diversity among mammalian AIM2-like receptors , 2012, The Journal of experimental medicine.
[131] D. Charnock-Jones,et al. Developmental control of the Nlrp6 inflammasome and a substrate, IL-18, in mammalian intestine. , 2011, American journal of physiology. Gastrointestinal and liver physiology.
[132] R. Spritz,et al. NLRP1 haplotypes associated with vitiligo and autoimmunity increase interleukin-1β processing via the NLRP1 inflammasome , 2013, Proceedings of the National Academy of Sciences.
[133] B. Chandran,et al. IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection. , 2011, Cell host & microbe.
[134] M. Harigai,et al. Interleukin 1 Receptor on Fibroblasts from Systemic Sclerosis Patients Induces Excessive Functional Responses to Interleukin 1β , 1993 .
[135] M. Seishima,et al. Interleukin‐17 expression in the urticarial rash of familial cold autoinflammatory syndrome: a case report , 2010, The British journal of dermatology.
[136] J. Ting,et al. Cutting Edge: Monarch-1 Suppresses Non-Canonical NF-κB Activation and p52-Dependent Chemokine Expression in Monocytes1 , 2007, The Journal of Immunology.
[137] W. Zou,et al. Cutting Edge: Opposite Effects of IL-1 and IL-2 on the Regulation of IL-17+ T Cell Pool IL-1 Subverts IL-2-Mediated Suppression1 , 2007, The Journal of Immunology.
[138] S. Srinivasula,et al. The PYRIN-CARD Protein ASC Is an Activating Adaptor for Caspase-1* , 2002, The Journal of Biological Chemistry.
[139] J. Mogridge,et al. Expression of Nlrp1b Inflammasome Components in Human Fibroblasts Confers Susceptibility to Anthrax Lethal Toxin , 2009, Infection and Immunity.
[140] J. Bertin,et al. NLRP3/Cryopyrin Is Necessary for Interleukin-1β (IL-1β) Release in Response to Hyaluronan, an Endogenous Trigger of Inflammation in Response to Injury* , 2009, Journal of Biological Chemistry.
[141] Zhigang Tian,et al. Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. , 2013, Immunity.
[142] J. Ting,et al. Monarch-1 suppresses non-canonical NF-kappaB activation and p52-dependent chemokine expression in monocytes. , 2007, Journal of immunology.
[143] C. Stehlik,et al. NLRP7 and related inflammasome activating pattern recognition receptors and their function in host defense and disease. , 2013, Microbes and infection.
[144] Lois J. Maltais,et al. The NLR gene family: a standard nomenclature. , 2008, Immunity.
[145] G. Superti-Furga,et al. An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome , 2009, Nature Immunology.
[146] J. Bertin,et al. Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. , 2006, Immunity.
[147] A. Fischer,et al. Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease. , 2010, Blood.
[148] A. Murphy,et al. Role of the leucine-rich repeat domain of cryopyrin/NALP3 in monosodium urate crystal-induced inflammation in mice. , 2010, Arthritis and rheumatism.
[149] E. Alnemri,et al. The Mitochondrial Antiviral Protein MAVS Associates with NLRP3 and Regulates Its Inflammasome Activity , 2013, The Journal of Immunology.
[150] K. Matsuo,et al. Identification of specific autoantigens in Sjögren's syndrome by SEREX , 2005, Immunology.
[151] David Miller,et al. Critical Role for Cryopyrin/Nalp3 in Activation of Caspase-1 in Response to Viral Infection and Double-stranded RNA*> , 2006, Journal of Biological Chemistry.
[152] S. Welkos,et al. Cutting Edge: Resistance to Bacillus anthracis Infection Mediated by a Lethal Toxin Sensitive Allele of Nalp1b/Nlrp1b , 2009, The Journal of Immunology.
[153] K. Tracey,et al. Novel role of PKR in inflammasome activation and HMGB1 release , 2012, Nature.
[154] J. Mogridge,et al. Activation of the Nlrp1b Inflammasome by Reduction of Cytosolic ATP , 2012, Infection and Immunity.
[155] M. Chamaillard,et al. Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition , 2004, The EMBO journal.
[156] F. Safavi,et al. The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF , 2011, Nature Immunology.
[157] S. Werner,et al. The Inflammasome Mediates UVB-Induced Activation and Secretion of Interleukin-1β by Keratinocytes , 2007, Current Biology.
[158] Kamila Belhocine,et al. Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1 , 2012, Nature.
[159] E. Alnemri,et al. Involvement of the AIM2, NLRC4, and NLRP3 Inflammasomes in Caspase-1 Activation by Listeria monocytogenes , 2010, Journal of Clinical Immunology.
[160] Jasmyn A. Dunn,et al. HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA , 2009, Science.
[161] J. Bertin,et al. Autolytic Proteolysis within the Function to Find Domain (FIIND) Is Required for NLRP1 Inflammasome Activity* , 2012, The Journal of Biological Chemistry.
[162] E. Alnemri,et al. Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation* , 2012, The Journal of Biological Chemistry.
[163] E. Elinav,et al. Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer , 2013, Proceedings of the National Academy of Sciences.
[164] D. Powell,et al. Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock , 2013, Science.
[165] F. Sallusto,et al. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. , 2007, Nature immunology.
[166] A. Martini,et al. Role of IL-1 Beta in the Development of Human TH17 Cells: Lesson from NLPR3 Mutated Patients , 2011, PloS one.
[167] D. Choubey,et al. Aim2 Deficiency Stimulates the Expression of IFN-Inducible Ifi202, a Lupus Susceptibility Murine Gene within the Nba2 Autoimmune Susceptibility Locus , 2010, The Journal of Immunology.
[168] M. T. Wong,et al. Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4 , 2013, Science.
[169] P. Bork,et al. Enterotypes of the human gut microbiome , 2011, Nature.
[170] H. Herfarth,et al. NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling. , 2012, Immunity.
[171] V. Hornung,et al. Intracellular DNA recognition , 2010, Nature Reviews Immunology.
[172] Christine E. Becker,et al. TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria , 2012, Cell.
[173] S. Akira,et al. Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3 , 2006, Nature.
[174] Yan A. Su,et al. Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma , 1997, Oncogene.
[175] J. Trapani,et al. Isotypic variants of the interferon-inducible transcriptional repressor IFI 16 arise through differential mRNA splicing. , 1998, Biochemistry.
[176] Eva Szomolanyi-Tsuda,et al. The AIM2 inflammasome is essential for host-defense against cytosolic bacteria and DNA viruses , 2010, Nature Immunology.
[177] F. Sutterwala,et al. Cutting Edge: Nlrp10 Is Essential for Protective Antifungal Adaptive Immunity against Candida albicans , 2012, The Journal of Immunology.
[178] M. T. McIntosh,et al. Pure Hemozoin Is Inflammatory In Vivo and Activates the NALP3 Inflammasome via Release of Uric Acid1 , 2009, The Journal of Immunology.
[179] D. Choubey,et al. Aim2 Deficiency in Mice Suppresses the Expression of the Inhibitory Fcγ Receptor (FcγRIIB) through the Induction of the IFN-Inducible p202, a Lupus Susceptibility Protein , 2011, The Journal of Immunology.
[180] T. Mandrup-Poulsen,et al. A choice of death – the signal-transduction of immune-mediated beta-cell apoptosis , 2001, Diabetologia.
[181] A. Alkhateeb,et al. Polymorphisms in NLRP1 gene and susceptibility to autoimmune thyroid disease , 2013, Autoimmunity.
[182] Ana Rodriguez,et al. Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome , 2010, European journal of immunology.
[183] P. Kovanen,et al. Extracellular Acidosis Is a Novel Danger Signal Alerting Innate Immunity via the NLRP3 Inflammasome , 2013, The Journal of Biological Chemistry.
[184] B. Koller,et al. NLRP1-Dependent Pyroptosis Leads to Acute Lung Injury and Morbidity in Mice , 2012, The Journal of Immunology.
[185] K. Ishii,et al. NLRP4 Negatively Regulates Autophagic Processes through an Association with Beclin1 , 2011, The Journal of Immunology.
[186] R. Eddy,et al. A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-γ in myeloid cells , 2004, Immunogenetics.
[187] F. Re,et al. Cutting Edge: Inflammasome Activation by Alum and Alum’s Adjuvant Effect Are Mediated by NLRP31 , 2008, The Journal of Immunology.
[188] F. Pio,et al. RPA nucleic acid-binding properties of IFI16-HIN200. , 2008, Biochimica et biophysica acta.
[189] S. Akira,et al. Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome , 2013, Nature Immunology.
[190] S. Ryter,et al. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. , 2011, Nature immunology.
[191] J. Ting,et al. CATERPILLER 16.2 (CLR16.2), a Novel NBD/LRR Family Member That Negatively Regulates T Cell Function* , 2005, Journal of Biological Chemistry.
[192] R. Johnstone,et al. The HIN-200 family: more than interferon-inducible genes? , 2005, Experimental cell research.
[193] J. Tschopp,et al. Malarial Hemozoin Is a Nalp3 Inflammasome Activating Danger Signal , 2009, PloS one.
[194] Jiujiu Yu,et al. Critical role for calcium mobilization in activation of the NLRP3 inflammasome , 2012, Proceedings of the National Academy of Sciences.
[195] F. Martinon,et al. Gout-associated uric acid crystals activate the NALP3 inflammasome , 2006, Nature.
[196] J. Ting,et al. Heat Shock Protein 90 Associates with Monarch-1 and Regulates Its Ability to Promote Degradation of NF-κB-Inducing Kinase1 , 2007, The Journal of Immunology.
[197] K. Rock,et al. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization , 2008, Nature Immunology.
[198] E. Latz. The inflammasomes: mechanisms of activation and function. , 2010, Current opinion in immunology.
[199] M. Chamaillard,et al. Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury , 2011, Proceedings of the National Academy of Sciences.
[200] N. Volkmann,et al. Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation. , 2007, Molecular cell.
[201] J. Tschopp,et al. NLRP3 inflammasome is required in murine asthma in the absence of aluminum adjuvant , 2011, Allergy.
[202] A. Bowie,et al. IFI16 is an innate immune sensor for intracellular DNA , 2010, Nature Immunology.
[203] A. Aderem,et al. Multiple Nod-Like Receptors Activate Caspase 1 during Listeria monocytogenes Infection12 , 2008, The Journal of Immunology.
[204] James L. Mueller,et al. Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies. , 2013, The Journal of clinical investigation.
[205] J. Tschopp,et al. A pilot study of IL-1 inhibition by anakinra in acute gout , 2007, Arthritis research & therapy.
[206] M. Braunstein,et al. The CATERPILLER Protein Monarch-1 Is an Antagonist of Toll-like Receptor-, Tumor Necrosis Factor α-, and Mycobacterium tuberculosis-induced Pro-inflammatory Signals* , 2005, Journal of Biological Chemistry.
[207] G. López-Castejón,et al. Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion via Assembly of the Inflammasome , 2012, The Journal of Biological Chemistry.
[208] D. C. Henckel,et al. Case report. , 1995, Journal.
[209] M. Harigai,et al. Interleukin 1 receptor on fibroblasts from systemic sclerosis patients induces excessive functional responses to interleukin 1 beta. , 1993, Biochemical and biophysical research communications.
[210] F. Martinon,et al. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. , 2002, Molecular cell.
[211] S. Smeekens,et al. Reactive oxygen species–independent activation of the IL-1β inflammasome in cells from patients with chronic granulomatous disease , 2010, Proceedings of the National Academy of Sciences.
[212] Yetao Wang,et al. PYPAF3, a PYRIN-containing APAF-1-like Protein, Is a Feedback Regulator of Caspase-1-dependent Interleukin-1β Secretion* , 2005, Journal of Biological Chemistry.
[213] J. Bertin,et al. NLRP6 Negatively Regulates Innate Immunity and Host Defense Against Bacterial Pathogens , 2012, Nature.
[214] G. Núñez,et al. K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. , 2013, Immunity.
[215] Anna K Rieger,et al. Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome , 2011, The Journal of Immunology.
[216] D. Kastner,et al. Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. , 2009, Immunity.
[217] Z. Ye,et al. ATP Binding by Monarch-1/NLRP12 Is Critical for Its Inhibitory Function , 2007, Molecular and Cellular Biology.
[218] Ruchi M. Newman,et al. Comparative analysis of apoptosis and inflammation genes of mice and humans. , 2003, Genome research.
[219] A. Osterman,et al. Bcl-2 and Bcl-XL Regulate Proinflammatory Caspase-1 Activation by Interaction with NALP1 , 2007, Cell.
[220] R. Germain,et al. The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation , 2013, Cell.
[221] E. Bochkareva,et al. From RPA to BRCA2: lessons from single-stranded DNA binding by the OB-fold. , 2004, Current opinion in structural biology.
[222] S. Akira,et al. ASC is essential for LPS‐induced activation of procaspase‐1 independently of TLR‐associated signal adaptor molecules , 2004, Genes to cells : devoted to molecular & cellular mechanisms.
[223] E. Alnemri,et al. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA , 2009, Nature.
[224] S. Akira,et al. IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice. , 2007, The Journal of clinical investigation.
[225] Maureen A. McGargill,et al. Cutting edge: critical role for PYCARD/ASC in the development of experimental autoimmune encephalomyelitis. , 2010, Journal of immunology.
[226] R. Vance,et al. Direct Proteolytic Cleavage of NLRP1B Is Necessary and Sufficient for Inflammasome Activation by Anthrax Lethal Factor , 2013, PLoS pathogens.
[227] V. Nizet,et al. A Nod2–nalp1 Complex Mediates Caspase-1-dependent Il-1 Secretion in Response to Bacillus Anthracis Infection and Muramyl Dipeptide Nod2, a Nod-like Receptor (nlr), Is an Intracellular Sensor of Bacterial Muramyl Dipeptide (mdp) That Was Suggested to Promote Secretion of the Proinflammatory Cytokine , 2022 .
[228] K. Schroder,et al. Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction. , 2012, Immunobiology.
[229] P. Vajjhala,et al. Multiple Binding Sites on the Pyrin Domain of ASC Protein Allow Self-association and Interaction with NLRP3 Protein* , 2012, The Journal of Biological Chemistry.
[230] S. Vogel,et al. Bacillus anthracis spores and lethal toxin induce IL‐1β via functionally distinct signaling pathways , 2008, European journal of immunology.
[231] Denis Gris,et al. Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling , 2011, Nature Immunology.
[232] M. Huang,et al. NLRP3 (NALP3, Cryopyrin) Facilitates In Vivo Caspase-1 Activation, Necrosis, and HMGB1 Release via Inflammasome-Dependent and -Independent Pathways1 , 2009, The Journal of Immunology.
[233] Richard A. Flavell,et al. Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants , 2008, Nature.
[234] H. Forman,et al. ATP Activates a Reactive Oxygen Species-dependent Oxidative Stress Response and Secretion of Proinflammatory Cytokines in Macrophages* , 2007, Journal of Biological Chemistry.