Remyelination trial failures: Repercussions of ignoring neurorehabilitation and exercise in repair.

[1]  J. Bansi,et al.  Systematic Review of Exercise Studies in Persons with Multiple Sclerosis: Exploring the Quality of Interventions According to the Principles of Exercise Training , 2021, Neurology and Therapy.

[2]  D. MacManus,et al.  Safety and efficacy of bexarotene in patients with relapsing-remitting multiple sclerosis (CCMR One): a randomised, double-blind, placebo-controlled, parallel-group, phase 2a study , 2021, The Lancet Neurology.

[3]  A. Dufour,et al.  Exercise rapidly alters proteomes in mice following spinal cord demyelination , 2021, Scientific Reports.

[4]  N. Penner,et al.  A pharmacokinetic and biomarker study of delayed-release dimethyl fumarate in subjects with secondary progressive multiple sclerosis: evaluation of cerebrospinal fluid penetration and the effects on exploratory biomarkers. , 2021, Multiple sclerosis and related disorders.

[5]  D. Arnold,et al.  Safety and efficacy of MD1003 (high-dose biotin) in patients with progressive multiple sclerosis (SPI2): a randomised, double-blind, placebo-controlled, phase 3 trial , 2020, The Lancet Neurology.

[6]  V. Yong,et al.  Exercise and the brain in multiple sclerosis , 2020, Multiple sclerosis.

[7]  E. Esposito,et al.  Antioxidant and Anti-inflammatory Effect of Nrf2 Inducer Dimethyl Fumarate in Neurodegenerative Diseases , 2020, Antioxidants.

[8]  Charles Tator,et al.  Delayed administration of the human anti-RGMa monoclonal antibody elezanumab promotes functional recovery including spontaneous voiding after spinal cord injury in rats , 2020, Neurobiology of Disease.

[9]  G. Comi,et al.  Siponimod (BAF312) Activates Nrf2 While Hampering NFκB in Human Astrocytes, and Protects From Astrocyte-Induced Neurodegeneration , 2020, Frontiers in Immunology.

[10]  V. Yong,et al.  Exercise in multiple sclerosis and its models: Focus on the central nervous system outcomes , 2020, Journal of neuroscience research.

[11]  B. Emery,et al.  Axoglial interactions in myelin plasticity: Evaluating the relationship between neuronal activity and oligodendrocyte dynamics , 2019, Glia.

[12]  M. Schwab,et al.  Enhancing rehabilitation and functional recovery after brain and spinal cord trauma with electrical neuromodulation , 2019, Current opinion in neurology.

[13]  S. Dietmann,et al.  Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells , 2019, Cell stem cell.

[14]  D. Centonze,et al.  Safety and efficacy of opicinumab in patients with relapsing multiple sclerosis (SYNERGY): a randomised, placebo-controlled, phase 2 trial , 2019, The Lancet Neurology.

[15]  M. Conda-Sheridan,et al.  A review of the molecular design and biological activities of RXR agonists , 2019, Medicinal research reviews.

[16]  M. Ploughman,et al.  Prolonged cortical silent period is related to poor fitness and fatigue, but not tumor necrosis factor, in Multiple Sclerosis , 2019, Clinical Neurophysiology.

[17]  T. Yamashita,et al.  Inhibiting repulsive guidance molecule-a suppresses secondary progression in mouse models of multiple sclerosis , 2018, Cell Death & Disease.

[18]  O. Kovalchuk,et al.  Multimodal Enhancement of Remyelination by Exercise with a Pivotal Role for Oligodendroglial PGC1α. , 2018, Cell reports.

[19]  J. Grutzendler,et al.  Lifelong cortical myelin plasticity and age-related degeneration in the live mammalian brain , 2018, Nature Neuroscience.

[20]  S. Galetta,et al.  Safety and efficacy of opicinumab in acute optic neuritis (RENEW): a randomised, placebo-controlled, phase 2 trial , 2017, The Lancet Neurology.

[21]  Gavin Giovannoni,et al.  Is multiple sclerosis a length-dependent central axonopathy? The case for therapeutic lag and the asynchronous progressive MS hypotheses. , 2017, Multiple sclerosis and related disorders.

[22]  D. Arnold,et al.  Lesion remyelinating activity of GSK239512 versus placebo in patients with relapsing-remitting multiple sclerosis: a randomised, single-blind, phase II study , 2016, Journal of Neurology.

[23]  F. Sedel,et al.  Targeting demyelination and virtual hypoxia with high-dose biotin as a treatment for progressive multiple sclerosis , 2016, Neuropharmacology.

[24]  Geoffroy Saussez,et al.  Rehabilitation of Motor Function after Stroke: A Multiple Systematic Review Focused on Techniques to Stimulate Upper Extremity Recovery , 2016, Front. Hum. Neurosci..

[25]  Bimal Lakhani,et al.  Motor Skill Acquisition Promotes Human Brain Myelin Plasticity , 2016, Neural plasticity.

[26]  Robin J. Vigouroux,et al.  Uncoupling Neogenin association with lipid rafts promotes neuronal survival and functional recovery after stroke , 2015, Cell Death and Disease.

[27]  D. Miller,et al.  Sample sizes for lesion magnetisation transfer ratio outcomes in remyelination trials for multiple sclerosis. , 2014, Multiple sclerosis and related disorders.

[28]  H. Praag,et al.  Bridging animal and human models of exercise-induced brain plasticity , 2013, Trends in Cognitive Sciences.

[29]  S. Mi,et al.  Blocking LINGO-1 as a Therapy to Promote CNS Repair: From Concept to the Clinic , 2013, CNS Drugs.

[30]  B. Seitz,et al.  A randomized, double‐blind, phase 2 study of erythropoietin in optic neuritis , 2012, Annals of neurology.

[31]  David H. Miller,et al.  Quantitative magnetic resonance of postmortem multiple sclerosis brain before and after fixation , 2008, Magnetic resonance in medicine.

[32]  J. Kleim,et al.  Principles of experience-dependent neural plasticity: implications for rehabilitation after brain damage. , 2008, Journal of speech, language, and hearing research : JSLHR.

[33]  Stephen J. Jones,et al.  A serial MRI study following optic nerve mean area in acute optic neuritis. , 2004, Brain : a journal of neurology.

[34]  Chao Zhao,et al.  The Age-Related Decrease in CNS Remyelination Efficiency Is Attributable to an Impairment of Both Oligodendrocyte Progenitor Recruitment and Differentiation , 2002, The Journal of Neuroscience.

[35]  J. Garthwaite,et al.  Lesional-targeting of neuroprotection to the inflammatory penumbra in experimental multiple sclerosis. , 2014, Brain : a journal of neurology.

[36]  P. Chambon,et al.  Retinoid X receptor gamma signaling accelerates CNS remyelination , 2011, Nature Neuroscience.

[37]  P. Rossini,et al.  Cerebral restorative plasticity from normal ageing to brain diseases: a "never ending story". , 2010, Restorative neurology and neuroscience.