Role of Placental Nutrient Sensing in Developmental Programming

Altered maternal nutrition and metabolism, restricted utero-placental blood flow, and other perturbations in the maternal compartment may disturb critical periods of fetal development resulting in increased susceptibility to develop disease in childhood and adult life. In response to these perturbations, changes in placental structure and function occur, which influence the supply of nutrients, oxygen, and methyl donors and alter the secretion of hormones and other signaling molecules into the fetal circulation. Thus, the placenta plays a critical role in modulating maternal-fetal resource allocation, thereby affecting fetal growth and the long-term health of the offspring.

[1]  Y. Kanai,et al.  Mammalian target of rapamycin signalling modulates amino acid uptake by regulating transporter cell surface abundance in primary human trophoblast cells , 2013, The Journal of physiology.

[2]  F. Rosario,et al.  Activation of placental mTOR signaling and amino acid transporters in obese women giving birth to large babies. , 2013, The Journal of clinical endocrinology and metabolism.

[3]  T. Powell,et al.  Placental transport in response to altered maternal nutrition , 2012, Journal of Developmental Origins of Health and Disease.

[4]  Jean X. Jiang,et al.  Chronic maternal infusion of full‐length adiponectin in pregnant mice down‐regulates placental amino acid transporter activity and expression and decreases fetal growth , 2012, The Journal of physiology.

[5]  P. Bossuyt,et al.  The sex-specific effects of famine on the association between placental size and later hypertension. , 2011, Placenta.

[6]  J. Eriksson,et al.  Mother's body size and placental size predict coronary heart disease in men. , 2011, European heart journal.

[7]  C. Sibley,et al.  Review: Adaptation in placental nutrient supply to meet fetal growth demand: implications for programming. , 2010, Placenta.

[8]  T. Powell,et al.  High‐fat diet before and during pregnancy causes marked up‐regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[9]  T. Powell,et al.  IFPA 2005 Award in Placentology Lecture. Human placental transport in altered fetal growth: does the placenta function as a nutrient sensor? -- a review. , 2006, Placenta.

[10]  K. Thornburg,et al.  Fetal roots of cardiac disease , 2005, Heart.

[11]  J. Friedman,et al.  Fetoplacental transport and utilization of amino acids in IUGR--a review. , 2005, Placenta.

[12]  Imran Y. Khan,et al.  Developmental programming of the metabolic syndrome by maternal nutritional imbalance: how strong is the evidence from experimental models in mammals? , 2004, The Journal of physiology.

[13]  P. Gluckman,et al.  Living with the Past: Evolution, Development, and Patterns of Disease , 2004, Science.

[14]  T. Powell,et al.  Alterations in the activity of placental amino acid transporters in pregnancies complicated by diabetes. , 2002, Diabetes.

[15]  T. Powell,et al.  Placental glucose transport and GLUT 1 expression in insulin-dependent diabetes. , 1999, American journal of obstetrics and gynecology.

[16]  C. Sibley,et al.  Altered activity of the system A amino acid transporter in microvillous membrane vesicles from placentas of macrosomic babies born to diabetic women. , 1994, The Journal of clinical investigation.