论文信息 - Transdermal nitrate therapy: bioavailability during exercise increases transiently after the daily change of patch.

Transdermal nitrate therapy: bioavailability during exercise increases transiently after the daily change of patch.

Ten volunteers carried a 10 mg 24 h -1 transdermal glyceryl trinitrate (GTN) patch for 24 h before moderate exercise. Plasma GTN-concentration increased significantly (P less than 0.05) by 19% to peak value at 15 min. Two hours after patch renewal repeat exercise increased GTN concentration by 56% (P less than 0.001). The two nitrate-concentration curves differed significantly (P less than 0.0001). Thus, change of patch augmented nitrate availability during exercise.

K. Gjesdal | T. Klemsdal | J. Bredesen | E. Rykke

[1] G. Reiniger,et al. [Interval therapy in effective treatment of angina pectoris using nitroglycerin patch systems. A controlled study with determination of nitroglycerin plasma levels]. , 1987, Herz.

[2] B. Woodcock,et al. Effect of posture on glyceryl trinitrate plasma concentrations following transdermal application. , 1987, British journal of clinical pharmacology.

[3] M. Degeorges,et al. The effects of moderate sustained exercise on the pharmacokinetics of nitroglycerine. , 1987, British journal of clinical pharmacology.

[4] K. Gjesdal,et al. Increased uptake of transdermal glyceryl trinitrate during physical exercise and during high ambient temperature. , 1986, American heart journal.

[5] T. Greibrokk,et al. Rapid, isothermal gas-liquid chromatographic determination of nitroglycerine in plasma using an electron-capture detector. II. , 1985, Journal of chromatography.

[6] S. Curry,et al. Influence of posture on plasma nitroglycerin [letter] , 1985 .