Smad3 is essential for polarization of tumor-associated neutrophils in non-small cell lung carcinoma

[1]  E. Lam,et al.  Single-cell RNA sequencing uncovers a neuron-like macrophage subset associated with cancer pain , 2022, Science advances.

[2]  K. To,et al.  TGF-β signaling networks in the tumor microenvironment. , 2022, Cancer letters.

[3]  S. Qin,et al.  Lentinan enhances the antitumor effects of Delta-like 1 via neutrophils , 2022, BMC cancer.

[4]  Guansong Wang,et al.  Extracellular HMGB1 Impairs Macrophage-Mediated Efferocytosis by Suppressing the Rab43-Controlled Cell Surface Transport of CD91 , 2022, Frontiers in Immunology.

[5]  E. Lam,et al.  Smad3 Promotes Cancer‐Associated Fibroblasts Generation via Macrophage–Myofibroblast Transition , 2021, Advanced science.

[6]  E. Lam,et al.  USMB-shMincle: a virus-free gene therapy for blocking M1/M2 polarization of tumor-associated macrophages , 2021, Molecular therapy oncolytics.

[7]  R. Holmdahl,et al.  Neutrophil-derived reactive oxygen species promote tumor colonization , 2021, Communications biology.

[8]  K. To,et al.  TGF-β Signaling: From Tissue Fibrosis to Tumor Microenvironment , 2021, International journal of molecular sciences.

[9]  Jason D. Buenrostro,et al.  The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments , 2021, Nature Communications.

[10]  Ling Wang,et al.  Algorithm-Based Meta-Analysis Reveals the Mechanistic Interaction of the Tumor Suppressor LIMD1 With Non-Small-Cell Lung Carcinoma , 2021, Frontiers in Oncology.

[11]  T. Goldmann,et al.  Phosphorylation of SMAD3 in immune cells predicts survival of patients with early stage non-small cell lung cancer , 2021, Journal for ImmunoTherapy of Cancer.

[12]  Shih-Ying Wu,et al.  Nicotine promotes breast cancer metastasis by stimulating N2 neutrophils and generating pre-metastatic niche in lung , 2021, Nature Communications.

[13]  S. Molina-Pinelo,et al.  Primary and Acquired Resistance to Immunotherapy in Lung Cancer: Unveiling the Mechanisms Underlying of Immune Checkpoint Blockade Therapy , 2020, Cancers.

[14]  Chen Yu,et al.  Long Non-coding RNA LRNA9884 Promotes Acute Kidney Injury via Regulating NF-kB-Mediated Transcriptional Activation of MIF , 2020, Frontiers in Physiology.

[15]  M. Renault,et al.  Desert Hedgehog-Driven Endothelium Integrity Is Enhanced by Gas1 (Growth Arrest-Specific 1) but Negatively Regulated by Cdon (Cell Adhesion Molecule-Related/Downregulated by Oncogenes) , 2020, Arteriosclerosis, Thrombosis and Vascular Biology.

[16]  Ying-ying Zhang,et al.  DPP4/CD32b/NF-κB Circuit: A Novel Druggable Target for Inhibiting CRP-Driven Diabetic Nephropathy. , 2020, Molecular therapy : the journal of the American Society of Gene Therapy.

[17]  A. Mantovani,et al.  Neutrophil diversity and plasticity in tumour progression and therapy , 2020, Nature Reviews Cancer.

[18]  Wenhui Hu,et al.  Discovery of a novel selective water-soluble SMAD3 inhibitor as an antitumor agent. , 2020, Bioorganic & medicinal chemistry letters.

[19]  Tin-Lap Lee,et al.  The Mincle/Syk/NF-κB Signaling Circuit Is Essential for Maintaining the Protumoral Activities of Tumor-Associated Macrophages , 2020, Cancer Immunology Research.

[20]  M. Pittet,et al.  Durable and controlled depletion of neutrophils in mice , 2020, Nature Communications.

[21]  N. Ahemad,et al.  Maslinic acid suppresses macrophage foam cells formation: Regulation of monocyte recruitment and macrophage lipids homeostasis. , 2020, Vascular pharmacology.

[22]  J. Cipolla-Neto,et al.  Neutrophil activation causes tumor regression in Walker 256 tumor-bearing rats , 2019, Scientific Reports.

[23]  A. Tanay,et al.  MetaCell: analysis of single-cell RNA-seq data using K-nn graph partitions , 2019, Genome Biology.

[24]  Ying-ying Zhang,et al.  LRNA9884, a Novel Smad3-Dependent Long Noncoding RNA, Promotes Diabetic Kidney Injury in db/db Mice via Enhancing MCP-1–Dependent Renal Inflammation , 2019, Diabetes.

[25]  Virginia Savova,et al.  Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species. , 2019, Immunity.

[26]  Eduard Batlle,et al.  Transforming Growth Factor-β Signaling in Immunity and Cancer. , 2019, Immunity.

[27]  Lai Guan Ng,et al.  Dimensionality reduction for visualizing single-cell data using UMAP , 2018, Nature Biotechnology.

[28]  Aviezer Lifshitz,et al.  MetaCell: analysis of single cell RNA-seq data using k-NN graph partitions , 2018, bioRxiv.

[29]  A. Jemal,et al.  Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries , 2018, CA: a cancer journal for clinicians.

[30]  Erik Sundström,et al.  RNA velocity of single cells , 2018, Nature.

[31]  J. Delisle,et al.  TGF-β in T Cell Biology: Implications for Cancer Immunotherapy , 2018, Cancers.

[32]  C. Zhang,et al.  Neutrophil‐Based Drug Delivery Systems , 2018, Advanced materials.

[33]  Yuquan Wei,et al.  Pharmacological activation of estrogen receptor beta augments innate immunity to suppress cancer metastasis , 2018, Proceedings of the National Academy of Sciences.

[34]  E. Ma,et al.  Translational control in the tumor microenvironment promotes lung metastasis: Phosphorylation of eIF4E in neutrophils , 2018, Proceedings of the National Academy of Sciences.

[35]  F. Ginhoux,et al.  Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions , 2018, Immunity.

[36]  Tin-Lap Lee,et al.  The proto-oncogene tyrosine protein kinase Src is essential for macrophage-myofibroblast transition during renal scarring. , 2018, Kidney international.

[37]  E. Jaffee,et al.  Tumor Mutational Burden and Response Rate to PD-1 Inhibition. , 2017, The New England journal of medicine.

[38]  E. Rozeman,et al.  Cancer Drug Addiction is Relayed by an ERK2-Dependent Phenotype Switch , 2017, Nature.

[39]  Ran Mo,et al.  Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence. , 2017, Nature nanotechnology.

[40]  Xiao-ming Meng,et al.  Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development , 2017, Nature Communications.

[41]  S. Singhal,et al.  Tumor-associated neutrophils display a distinct N1 profile following TGFβ modulation: A transcriptomics analysis of pro- vs. antitumor TANs , 2016, Oncoimmunology.

[42]  K. E. Visser,et al.  Neutrophils in cancer: neutral no more , 2016, Nature Reviews Cancer.

[43]  Klaus Hansen,et al.  An interactive environment for agile analysis and visualization of ChIP-sequencing data , 2016, Nature Structural &Molecular Biology.

[44]  C. Caldas,et al.  Context-Specific Effects of TGF-β/SMAD3 in Cancer Are Modulated by the Epigenome , 2015, Cell reports.

[45]  A. Mes-Masson,et al.  Granulocytic immune infiltrates are essential for the efficient formation of breast cancer liver metastases , 2015, Breast Cancer Research.

[46]  Jochen Wilhelm,et al.  Immune and Inflammatory Cell Composition of Human Lung Cancer Stroma , 2015, PloS one.

[47]  Benjamin L. Allen,et al.  Dosage-dependent regulation of pancreatic cancer growth and angiogenesis by hedgehog signaling. , 2014, Cell reports.

[48]  Luqia Hou,et al.  Role of Extracellular Matrix Signaling Cues in Modulating Cell Fate Commitment for Cardiovascular Tissue Engineering , 2014, Advanced healthcare materials.

[49]  Laurens van der Maaten,et al.  Accelerating t-SNE using tree-based algorithms , 2014, J. Mach. Learn. Res..

[50]  C. Klein,et al.  Glycoengineered CD20 antibody obinutuzumab activates neutrophils and mediates phagocytosis through CD16B more efficiently than rituximab. , 2013, Blood.

[51]  L. Levy,et al.  Tumor-associated neutrophils (TAN) develop pro-tumorigenic properties during tumor progression , 2013, Cancer Immunology, Immunotherapy.

[52]  R. Schreiber,et al.  Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion , 2011, Science.

[53]  G. Cheng,et al.  Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN. , 2009, Cancer cell.

[54]  H. Wolff,et al.  Transforming growth factor-β/Smad3 signalling regulates inflammatory responses in a murine model of contact hypersensitivity , 2008, The British journal of dermatology.

[55]  James B. Mitchell,et al.  Absence of Smad3 induces neutrophil migration after cutaneous irradiation: possible contribution to subsequent radioprotection. , 2008, The American journal of pathology.

[56]  R. Isseroff,et al.  Dynamics of neutrophil infiltration during cutaneous wound healing and infection using fluorescence imaging. , 2008, The Journal of investigative dermatology.

[57]  T. Mayadas,et al.  Human neutrophil Fcgamma receptors initiate and play specialized nonredundant roles in antibody-mediated inflammatory diseases. , 2008, Immunity.

[58]  S. Rankin,et al.  The CXC chemokine MIP-2 stimulates neutrophil mobilization from the rat bone marrow in a CD49d-dependent manner. , 2005, Blood.

[59]  A. Roberts,et al.  Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF‐β , 1999, The EMBO journal.