Regulation of antigen presentation and cross-presentation in the dendritic cell network: facts, hypothesis, and immunological implications.

[1]  G. Belz,et al.  Cross‐presentation, dendritic cell subsets, and the generation of immunity to cellular antigens , 2004, Immunological reviews.

[2]  M. Jondal,et al.  Alternative processing for MHC class I presentation by immature and CpG‐activated dendritic cells , 2004, European journal of immunology.

[3]  H. Ploegh,et al.  Membrane specializations and endosome maturation in dendritic cells and B cells. , 2004, Trends in cell biology.

[4]  J. Villadangos,et al.  Dendritic cells constitutively present self antigens in their immature state in vivo and regulate antigen presentation by controlling the rates of MHC class II synthesis and endocytosis. , 2004, Blood.

[5]  J. Villadangos,et al.  Lymphoid organ dendritic cells: beyond the Langerhans cells paradigm , 2004, Immunology and cell biology.

[6]  H. Ploegh,et al.  Control of cross‐presentation during dendritic cell maturation , 2004, European journal of immunology.

[7]  A. Avery,et al.  Dendritic Cells from Malaria-Infected Mice Are Fully Functional APC 1 , 2004, The Journal of Immunology.

[8]  J. Yewdell,et al.  Making sense of mass destruction: quantitating MHC class I antigen presentation , 2003, Nature Reviews Immunology.

[9]  Mark M. Davis,et al.  T-cell-antigen recognition and the immunological synapse , 2003, Nature Reviews Immunology.

[10]  Alexander H Enk,et al.  Induction of tolerogenic DCs: 'you are what you eat'. , 2003, Trends in immunology.

[11]  H. Ploegh,et al.  Requirements for T Cell-Polarized Tubulation of Class II+ Compartments in Dendritic Cells 1 , 2003, The Journal of Immunology.

[12]  Timothy K Starr,et al.  Positive and negative selection of T cells. , 2003, Annual review of immunology.

[13]  R. Steinman,et al.  Tolerogenic dendritic cells. , 2003, Annual review of immunology.

[14]  J. Villadangos,et al.  The Protease Inhibitor Cystatin C Is Differentially Expressed among Dendritic Cell Populations, but Does Not Control Antigen Presentation 1 , 2003, The Journal of Immunology.

[15]  P. Allavena,et al.  Cross-Linking of the Mannose Receptor on Monocyte-Derived Dendritic Cells Activates an Anti-Inflammatory Immunosuppressive Program 1 , 2003, The Journal of Immunology.

[16]  Kaan E. Biron,et al.  Control of dendritic cell cross-presentation by the major histocompatibility complex class I cytoplasmic domain , 2003, Nature Immunology.

[17]  H. Ploegh,et al.  T Cells Induce Extended Class II MHC Compartments in Dendritic Cells in a Toll-Like Receptor-Dependent Manner 1 , 2003, The Journal of Immunology.

[18]  R. Tampé,et al.  Early phagosomes in dendritic cells form a cellular compartment sufficient for cross presentation of exogenous antigens , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[19]  C. Melief,et al.  Mini‐review: Regulation of cytotoxic T lymphocyte responses by dendritic cells: peaceful coexistence of cross‐priming and direct priming? , 2003, European journal of immunology.

[20]  J. Davoust,et al.  ER–phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells , 2003, Nature.

[21]  Etienne Gagnon,et al.  Phagosomes are competent organelles for antigen cross-presentation , 2003, Nature.

[22]  G. Belz,et al.  Most lymphoid organ dendritic cell types are phenotypically and functionally immature. , 2003, Blood.

[23]  Y. Kooyk,et al.  DC-SIGN: escape mechanism for pathogens , 2003, Nature Reviews Immunology.

[24]  M. Nolte,et al.  A Conduit System Distributes Chemokines and Small Blood-borne Molecules through the Splenic White Pulp , 2003, The Journal of experimental medicine.

[25]  E. Sercarz,et al.  MHC-guided processing: binding of large antigen fragments , 2003, Nature Reviews Immunology.

[26]  M. Jenkins,et al.  Antigen presentation to naive CD4 T cells in the lymph node , 2003, Nature Immunology.

[27]  Li Wu,et al.  CD8α+ mouse spleen dendritic cells do not originate from the CD8α- dendritic cell subset , 2003 .

[28]  I. Mellman,et al.  Presentation of Exogenous Antigens on Major Histocompatibility Complex (MHC) Class I and MHC Class II Molecules Is Differentially Regulated during Dendritic Cell Maturation , 2003, The Journal of experimental medicine.

[29]  P. Sly,et al.  Bidirectional Interactions between Antigen-bearing Respiratory Tract Dendritic Cells (DCs) and T Cells Precede the Late Phase Reaction in Experimental Asthma , 2003, The Journal of experimental medicine.

[30]  A. Rudensky,et al.  Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity. , 2003, Immunity.

[31]  C. Ardavı́n.  Origin, precursors and differentiation of mouse dendritic cells , 2003, Nature Reviews Immunology.

[32]  E. Unanue,et al.  Dendritic Cells Process and Present Antigens Across A Range of Maturation States1 , 2003, The Journal of Immunology.

[33]  A. Rudensky,et al.  Lysosomal cysteine proteases regulate antigen presentation , 2003, Nature Reviews Immunology.

[34]  C. Nicchitta.  Re-evaluating the role of heat-shock protein–peptide interactions in tumour immunity , 2003, Nature Reviews Immunology.

[35]  R. Pauwels,et al.  Accelerated airway dendritic cell maturation, trafficking, and elimination in a mouse model of asthma. , 2003, American journal of respiratory cell and molecular biology.

[36]  S. Akira,et al.  A Subset of Toll-Like Receptor Ligands Induces Cross-presentation by Bone Marrow-Derived Dendritic Cells1 , 2003, The Journal of Immunology.

[37]  P. Cresswell,et al.  Regulation of MHC Class I Transport in Human Dendritic Cells and the Dendritic-Like Cell Line KG-11 , 2003, The Journal of Immunology.

[38]  E. Unanue,et al.  Interferon-producing Cells Fail to Induce Proliferation of Naive T Cells but Can Promote Expansion and T Helper 1 Differentiation of Antigen-experienced Unpolarized T Cells , 2003, The Journal of experimental medicine.

[39]  R. Steinman,et al.  The use of dendritic cells in cancer immunotherapy. , 2003, Current opinion in immunology.

[40]  Chad H. Koonce,et al.  DM Loss in k Haplotype Mice Reveals Isotype-Specific Chaperone Requirements 1 , 2003, The Journal of Immunology.

[41]  M. Desjardins,et al.  ER-mediated phagocytosis: a new membrane for new functions , 2003, Nature Reviews Immunology.

[42]  P. Benaroch,et al.  Asparagine endopeptidase can initiate the removal of the MHC class II invariant chain chaperone. , 2003, Immunity.

[43]  Shu-Bing Qian,et al.  Quantitating protein synthesis, degradation, and endogenous antigen processing. , 2003, Immunity.

[44]  I. Mellman,et al.  Activation of Lysosomal Function During Dendritic Cell Maturation , 2003, Science.

[45]  P. Hertzog,et al.  Dendritic cell precursor populations of mouse blood: identification of the murine homologues of human blood plasmacytoid pre-DC2 and CD11c+ DC1 precursors. , 2003, Blood.

[46]  I. Sandlie,et al.  The cytoplasmic tail of invariant chain modulates antigen processing and presentation , 2003, European journal of immunology.

[47]  N. Romani,et al.  Visualization and characterization of migratory Langerhans cells in murine skin and lymph nodes by antibodies against Langerin/CD207. , 2003, The Journal of investigative dermatology.

[48]  J. Sprent,et al.  Cytokines and T-cell homeostasis. , 2003, Current opinion in immunology.

[49]  Simon C Watkins,et al.  Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells: dependence on complement receptors and effect on cytokine production. , 2003, Blood.

[50]  Hidde L Ploegh,et al.  Proteolysis and antigen presentation by MHC class II molecules , 2002, Advances in Immunology.

[51]  H. Kalbacher,et al.  Inflammatory stimuli recruit cathepsin activity to late endosomal compartments in human dendritic cells , 2002, European journal of immunology.

[52]  H. Geuze,et al.  MHC Class II Compartments in Human Dendritic Cells Undergo Profound Structural Changes Upon Activation , 2002, Traffic.

[53]  Li Wu,et al.  Mouse Plasmacytoid Cells , 2002, The Journal of experimental medicine.

[54]  R. Maehr,et al.  Invariant Chain Controls the Activity of Extracellular Cathepsin L , 2002, The Journal of experimental medicine.

[55]  Clare L. Bennett,et al.  Rapid constitutive generation of a specific peptide‐MHC class II complex from intact exogenous protein in immature murine dendritic cells , 2002, European journal of immunology.

[56]  Scott N. Mueller,et al.  The CD8α+ Dendritic Cell Is Responsible for Inducing Peripheral Self-Tolerance to Tissue-associated Antigens , 2002, The Journal of experimental medicine.

[57]  Ethan M. Shevach,et al.  Constitutive Presentation of a Natural Tissue Autoantigen Exclusively by Dendritic Cells in the Draining Lymph Node , 2002, The Journal of experimental medicine.

[58]  C. Reis e Sousa,et al.  Cross‐presentation of cell‐associated antigens by CD8α+ dendritic cells is attributable to their ability to internalize dead cells , 2002, Immunology.

[59]  M. Bevan,et al.  Constitutive versus Activation-dependent Cross-Presentation of Immune Complexes by CD8+ and CD8− Dendritic Cells In Vivo , 2002, The Journal of experimental medicine.

[60]  R. Zinkernagel.  On cross‐priming of MHC class I‐specific CTL: rule or exception? , 2002, European journal of immunology.

[61]  D. Tough,et al.  Developmental kinetics and lifespan of dendritic cells in mouse lymphoid organs. , 2002, Blood.

[62]  M. Rescigno.  Dendritic cells and the complexity of microbial infection. , 2002, Trends in microbiology.

[63]  D. Toomre,et al.  Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane , 2002, Nature.

[64]  Jan Cerny,et al.  T-cell engagement of dendritic cells rapidly rearranges MHC class II transport , 2002, Nature.

[65]  J. Davoust,et al.  Accumulation of Immature Langerhans Cells in Human Lymph Nodes Draining Chronically Inflamed Skin , 2002, The Journal of experimental medicine.

[66]  Hidde L. Ploegh,et al.  Analysis of Protease Activity in Live Antigen-presenting Cells Shows Regulation of the Phagosomal Proteolytic Contents During Dendritic Cell Activation , 2002, The Journal of experimental medicine.

[67]  T. Luft,et al.  Functionally distinct dendritic cell (DC) populations induced by physiologic stimuli: prostaglandin E(2) regulates the migratory capacity of specific DC subsets. , 2002, Blood.

[68]  C. Arias,et al.  Characterization of a new subpopulation of mouse CD8alpha+ B220+ dendritic cells endowed with type 1 interferon production capacity and tolerogenic potential. , 2002, Blood.

[69]  H. Hochrein,et al.  Hierarchy of Susceptibility of Dendritic Cell Subsets to Infection by Leishmania major: Inverse Relationship to Interleukin-12 Production , 2002, Infection and Immunity.

[70]  A. Motta,et al.  The cytoplasmic tail of invariant chain regulates endosome fusion and morphology. , 2002, Molecular biology of the cell.

[71]  M. Colonna,et al.  Interferon-producing cells: on the front line in immune responses against pathogens. , 2002, Current opinion in immunology.

[72]  Christoph Peters,et al.  Cathepsin L Regulates CD4+ T Cell Selection Independently of Its Effect on Invariant Chain , 2002, The Journal of experimental medicine.

[73]  R. Steinman,et al.  The CD8+ Dendritic Cell Subset Selectively Endocytoses Dying Cells in Culture and In Vivo , 2002, The Journal of experimental medicine.

[74]  P. Pierre,et al.  Transient aggregation of ubiquitinated proteins during dendritic cell maturation , 2002, Nature.

[75]  M. Winslow,et al.  Major Histocompatibility Complex Class II Presentation of Cell-associated Antigen Is Mediated by CD8α+ Dendritic Cells In Vivo , 2002, The Journal of experimental medicine.

[76]  Meredith O'Keeffe,et al.  Effects of administration of progenipoietin 1, Flt-3 ligand, granulocyte colony-stimulating factor, and pegylated granulocyte-macrophage colony-stimulating factor on dendritic cell subsets in mice. , 2002, Blood.

[77]  P. Srivastava.  Roles of heat-shock proteins in innate and adaptive immunity , 2002, Nature Reviews Immunology.

[78]  M. Colonna,et al.  Tolerization of dendritic cells by TS cells: the crucial role of inhibitory receptors ILT3 and ILT4 , 2002, Nature Immunology.

[79]  Yong‐jun Liu,et al.  Mouse and human dendritic cell subtypes , 2002, Nature Reviews Immunology.

[80]  G. Freeman,et al.  The B7–CD28 superfamily , 2002, Nature Reviews Immunology.

[81]  L. Leserman,et al.  Induction of MHC Class I Presentation of Exogenous Antigen by Dendritic Cells Is Controlled by CD4+ T Cells Engaging Class II Molecules in Cholesterol-Rich Domains1 , 2002, The Journal of Immunology.

[82]  H. Ploegh,et al.  Uncoating ATPase Hsc70 is recruited by invariant chain and controls the size of endocytic compartments , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[83]  Michel C. Nussenzweig,et al.  Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[84]  P Björck,et al.  Isolation and characterization of plasmacytoid dendritic cells from Flt3 ligand and granulocyte-macrophage colony-stimulating factor-treated mice. , 2001, Blood.

[85]  Marc Dalod,et al.  Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology , 2001, Nature Immunology.

[86]  R. Locksley,et al.  Regulation of CD1 function and NK1.1(+) T cell selection and maturation by cathepsin S. , 2001, Immunity.

[87]  Ruslan Medzhitov,et al.  Toll-like receptors and innate immunity , 2001, Nature Reviews Immunology.

[88]  R. Darnell,et al.  Dendritic cell maturation is required for the cross-tolerization of CD8+ T cells , 2001, Nature Immunology.

[89]  W. Heath,et al.  Immunity or tolerance? That is the question for dendritic cells , 2001, Nature Immunology.

[90]  M. Gunn,et al.  Cd11c+B220+Gr-1+ Cells in Mouse Lymph Nodes and Spleen Display Characteristics of Plasmacytoid Dendritic Cells , 2001, The Journal of experimental medicine.

[91]  J. E. Gretz,et al.  Spatial and molecular organization of lymph node T cell cortex: a labyrinthine cavity bounded by an epithelium-like monolayer of fibroblastic reticular cells anchored to basement membrane-like extracellular matrix. , 2001, International immunology.

[92]  Jean Gruenberg,et al.  The endocytic pathway: a mosaic of domains , 2001, Nature Reviews Molecular Cell Biology.

[93]  A. Rudensky,et al.  Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells , 2001, The Journal of cell biology.

[94]  Michel C. Nussenzweig,et al.  Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in Vivo , 2001, The Journal of experimental medicine.

[95]  J. Villadangos,et al.  Presentation of antigens by MHC class II molecules: getting the most out of them. , 2001, Molecular immunology.

[96]  M. Wright,et al.  Molecular cloning of a C-type lectin superfamily protein differentially expressed by CD8alpha(-) splenic dendritic cells. , 2001, Molecular immunology.

[97]  H. Ploegh,et al.  The p41 isoform of invariant chain is a chaperone for cathepsin L , 2001, The EMBO journal.

[98]  J. Calafat,et al.  Regulation of MHC Class II Antigen Presentation by Sorting of Recycling HLA-DM/DO and Class II within the Multivesicular Body1 , 2001, The Journal of Immunology.

[99]  C. Benoist,et al.  The Dendritic Cell Populations of Mouse Lymph Nodes1 , 2001, The Journal of Immunology.

[100]  B. Hock,et al.  Phenotypic characterization of five dendritic cell subsets in human tonsils. , 2001, The American journal of pathology.

[101]  P. Koebel,et al.  In Vivo-Matured Langerhans Cells Continue to Take Up and Process Native Proteins Unlike In Vitro-Matured Counterparts , 2001, The Journal of Immunology.

[102]  A. Samri,et al.  Investigation of human spleen dendritic cell phenotype and distribution reveals evidence of in vivo activation in a subset of organ donors. , 2001, Blood.

[103]  J. Villadangos,et al.  MHC class II expression is regulated in dendritic cells independently of invariant chain degradation. , 2001, Immunity.

[104]  H. Ploegh,et al.  Individual cathepsins degrade immune complexes internalized by antigen‐presenting cells via Fcγ receptors , 2001, European journal of immunology.

[105]  W. Heath,et al.  Cutting Edge: Intravenous Soluble Antigen Is Presented to CD4 T Cells by CD8− Dendritic Cells, but Cross-Presented to CD8 T Cells by CD8+ Dendritic Cells1 , 2001, The Journal of Immunology.

[106]  H. Ploegh,et al.  Cytokines Regulate Proteolysis in Major Histocompatibility Complex Class II–Dependent Antigen Presentation by Dendritic Cells , 2001, The Journal of experimental medicine.

[107]  Chad H. Koonce,et al.  Relaxed DM Requirements During Class II Peptide Loading and CD4+ T Cell Maturation in BALB/c Mice1 , 2001, The Journal of Immunology.

[108]  C. Reis e Sousa,et al.  Mature T cell seeks antigen for meaningful relationship in lymph node , 2001, Immunology.

[109]  G. Trinchieri,et al.  Human thymus contains IFN-alpha-producing CD11c(-), myeloid CD11c(+), and mature interdigitating dendritic cells. , 2001, The Journal of clinical investigation.

[110]  N. Mavaddat,et al.  Human thymus contains 2 distinct dendritic cell populations. , 2001, Blood.

[111]  Simon C Watkins,et al.  Dendritic Cells Acquire Antigens from Live Cells for Cross-Presentation to CTL1 , 2001, The Journal of Immunology.

[112]  R. Zinkernagel,et al.  Rapid Peptide Turnover and Inefficient Presentation of Exogenous Antigen Critically Limit the Activation of Self-Reactive CTL by Dendritic Cells1 , 2001, The Journal of Immunology.

[113]  J. Salamero,et al.  Modulation of MHC class II transport and lysosome distribution by macrophage-colony stimulating factor in human dendritic cells derived from monocytes. , 2001, Journal of cell science.

[114]  Etienne Gagnon,et al.  The Phagosome Proteome: Insight into Phagosome Functions , 2001 .

[115]  R. Pauwels,et al.  Specific Migratory Dendritic Cells Rapidly Transport Antigen from the Airways to the Thoracic Lymph Nodes , 2001, The Journal of experimental medicine.

[116]  A. D'amico,et al.  The Development, Maturation, and Turnover Rate of Mouse Spleen Dendritic Cell Populations , 2000, The Journal of Immunology.

[117]  P. Kourilsky,et al.  Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion. , 2000, Immunity.

[118]  P. Romero,et al.  OmpA targets dendritic cells, induces their maturation and delivers antigen into the MHC class I presentation pathway , 2000, Nature Immunology.

[119]  A. Dalloul,et al.  Identification of mature and immature human thymic dendritic cells that differentially express HLA‐DR and interleukin‐3 receptor in vivo , 2000, Journal of leukocyte biology.

[120]  Stephen Shaw,et al.  Lymph-Borne Chemokines and Other Low Molecular Weight Molecules Reach High Endothelial Venules via Specialized Conduits While a Functional Barrier Limits Access to the Lymphocyte Microenvironments in Lymph Node Cortex , 2000, The Journal of experimental medicine.

[121]  P. Wolters,et al.  Importance of lysosomal cysteine proteases in lung disease , 2000, Respiratory research.

[122]  P. Koebel,et al.  Anatomical Origin of Dendritic Cells Determines Their Life Span in Peripheral Lymph Nodes , 2000, The Journal of Immunology.

[123]  R. Steinman,et al.  The Dendritic Cell Receptor for Endocytosis, Dec-205, Can Recycle and Enhance Antigen Presentation via Major Histocompatibility Complex Class II–Positive Lysosomal Compartments , 2000, The Journal of cell biology.

[124]  A. Sher,et al.  CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal. , 2000, Immunity.

[125]  I. Mellman,et al.  Developmental Control of Endocytosis in Dendritic Cells by Cdc42 , 2000, Cell.

[126]  P. Roche,et al.  Concentration of MHC class II molecules in lipid rafts facilitates antigen presentation , 2000, Nature Immunology.

[127]  A. Prescott,et al.  Rac is required for constitutive macropinocytosis by dendritic cells but does not control its downregulation , 2000, Current Biology.

[128]  A. Purcell,et al.  The peptide-loading complex and ligand selection during the assembly of HLA class I molecules. , 2000, Molecular immunology.

[129]  C. Harding,et al.  Phagosomes Acquire Nascent and Recycling Class II MHC Molecules but Primarily Use Nascent Molecules in Phagocytic Antigen Processing1 , 2000, The Journal of Immunology.

[130]  P. Ricciardi-Castagnoli,et al.  Dendritic Cells Discriminate between Yeasts and Hyphae of the Fungus Candida albicans , 2000, The Journal of experimental medicine.

[131]  R. Steinman,et al.  Transport of peptide-MHC class II complexes in developing dendritic cells. , 2000, Science.

[132]  Jonathan W. Yewdell,et al.  Rapid degradation of a large fraction of newly synthesized proteins by proteasomes , 2000, Nature.

[133]  J. Neefjes,et al.  The major substrates for TAP in vivo are derived from newly synthesized proteins , 2000, Nature.

[134]  V. Herzog,et al.  Cholera Toxin Is Exported from Microsomes by the Sec61p Complex , 2000, The Journal of cell biology.

[135]  Ira Mellman,et al.  The Formation of Immunogenic Major Histocompatibility Complex Class II–Peptide Ligands in Lysosomal Compartments of Dendritic Cells Is Regulated by Inflammatory Stimuli , 2000, The Journal of experimental medicine.

[136]  Li Wu,et al.  CD4 and CD8 Expression by Dendritic Cell Subtypes in Mouse Thymus and Spleen1 , 2000, The Journal of Immunology.

[137]  A. Engel,et al.  The importance of aquaporin water channel protein structures , 2000, The EMBO journal.

[138]  H. Ploegh,et al.  Proteolysis in MHC class II antigen presentation: who's in charge? , 2000, Immunity.

[139]  H. Ploegh,et al.  Early endosomal maturation of MHC class II molecules independently of cysteine proteases and H‐2DM , 2000, The EMBO journal.

[140]  A. Lanzavecchia,et al.  The Role of Aquaporins in Dendritic Cell Macropinocytosis , 2000, The Journal of experimental medicine.

[141]  F. Huang,et al.  A Discrete Subpopulation of Dendritic Cells Transports Apoptotic Intestinal Epithelial Cells to T Cell Areas of Mesenteric Lymph Nodes , 2000, The Journal of experimental medicine.

[142]  R. Steinman,et al.  The Induction of Tolerance by Dendritic Cells That Have Captured Apoptotic Cells , 2000, The Journal of experimental medicine.

[143]  P. Cresswell,et al.  Enzymatic reduction of disulfide bonds in lysosomes: characterization of a gamma-interferon-inducible lysosomal thiol reductase (GILT). , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[144]  N. Shastri,et al.  Bacterial Proteins Can Be Processed by Macrophages in a Transporter Associated with Antigen Processing-Independent, Cysteine Protease-Dependent Manner for Presentation by MHC Class I Molecules1 , 2000, The Journal of Immunology.

[145]  L. Santambrogio,et al.  Abundant empty class II MHC molecules on the surface of immature dendritic cells. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[146]  D. Weber,et al.  Peptide exchange in MHC molecules , 1999, Immunological reviews.

[147]  O. Bakke,et al.  Intracellular traffic to compartments for MHC class II peptide loading: signals for endosomal and polarized sorting , 1999, Immunological reviews.

[148]  G. Hämmerling,et al.  The impact of the non‐classical MHC proteins HLA‐DM and HLA‐DO on loading of MHC class II molecules , 1999, Immunological reviews.

[149]  P. Cresswell,et al.  The nature of the MHC class I peptide loading complex , 1999, Immunological reviews.

[150]  Hidde L. Ploegh,et al.  Cathepsin S Controls the Trafficking and Maturation of Mhc Class II Molecules in Dendritic Cells , 1999, The Journal of cell biology.

[151]  Sebastian Amigorena,et al.  Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells , 1999, Nature Cell Biology.

[152]  J. Brodsky,et al.  ER protein quality control and proteasome-mediated protein degradation. , 1999, Seminars in cell & developmental biology.

[153]  J. Neefjes,et al.  Recycling MHC class I molecules and endosomal peptide loading. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[154]  S. Gordon,et al.  Mannose Receptor and Its Putative Ligands in Normal Murine Lymphoid and Nonlymphoid Organs: In Situ Expression of Mannose Receptor by Selected Macrophages, Endothelial Cells, Perivascular Microglia, and Mesangial Cells, but not Dendritic Cells , 1999, The Journal of experimental medicine.

[155]  R. Germain,et al.  Analysis of adjuvant function by direct visualization of antigen presentation in vivo: endotoxin promotes accumulation of antigen-bearing dendritic cells in the T cell areas of lymphoid tissue. , 1999, Journal of immunology.

[156]  A. Stagg,et al.  Murine dendritic cells internalize Leishmania major promastigotes, produce IL‐12 p40 and stimulate primary T cell proliferation in vitro , 1999, European journal of immunology.

[157]  J. Neefjes.  CIIV, MIIC and other compartments for MHC class II loading , 1999, European journal of immunology.

[158]  G. Dranoff,et al.  Cathepsin S required for normal MHC class II peptide loading and germinal center development. , 1999, Immunity.

[159]  P. Cresswell,et al.  Human epidermal Langerhans cells lack functional mannose receptors and a fully developed endosomal/lysosomal compartment for loading of HLA class II molecules , 1999, European journal of immunology.

[160]  A. Rudensky,et al.  Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice. , 1999, Immunity.

[161]  P. Ricciardi-Castagnoli,et al.  Fcγ Receptor–mediated Induction of Dendritic Cell Maturation and Major Histocompatibility Complex Class I–restricted Antigen Presentation after Immune Complex Internalization , 1999, The Journal of experimental medicine.

[162]  F. Anjuère,et al.  Definition of dendritic cell subpopulations present in the spleen, Peyer's patches, lymph nodes, and skin of the mouse. , 1999, Blood.

[163]  M. J. Kohn,et al.  You Are What You Eat , 1999, Science.

[164]  R. Steinman,et al.  Efficient Presentation of Phagocytosed Cellular Fragments on the Major Histocompatibility Complex Class II Products of Dendritic Cells , 1998, The Journal of experimental medicine.

[165]  S. Ceman,et al.  Alteration of a Single Hydrogen Bond between Class II Molecules and Peptide Results in Rapid Degradation of Class II Molecules after Invariant Chain Removal , 1998, The Journal of experimental medicine.

[166]  C. Benoist,et al.  The phenotype of H‐2M‐deficient mice is dependent on the MHC class II molecules expressed , 1998, European journal of immunology.

[167]  T. Yoshino,et al.  Heterogeneity of dendritic cells in human superficial lymph node: in vitro maturation of immature dendritic cells into mature or activated interdigitating reticulum cells. , 1998, The American journal of pathology.

[168]  I. Mellman,et al.  Developmental Regulation of Invariant Chain Proteolysis Controls MHC Class II Trafficking in Mouse Dendritic Cells , 1998, Cell.

[169]  H. Geuze.  The role of endosomes and lysosomes in MHC class II functioning. , 1998, Immunology today.

[170]  P. Ricciardi-Castagnoli,et al.  Bacteria-induced neo-biosynthesis, stabilization, and surface expression of functional class I molecules in mouse dendritic cells. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[171]  R. Steinman,et al.  Dendritic cells and the control of immunity , 1998, Nature.

[172]  J. Salamero,et al.  Intracellular pathway for the generation of functional MHC class II peptide complexes in immature human dendritic cells. , 1998, Journal of immunology.

[173]  P. Ricciardi-Castagnoli,et al.  Dendritic cell maturation and antigen presentation in the absence of invariant chain. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[174]  J. Neefjes,et al.  Interleukin-10 Down-Regulates MHC Class II αβ Peptide Complexes at the Plasma Membrane of Monocytes by Affecting Arrival and Recycling , 1997 .

[175]  P. Ricciardi-Castagnoli,et al.  Intracellular routes and selective retention of antigens in mildly acidic cathepsin D/lysosome-associated membrane protein-1/MHC class II-positive vesicles in immature dendritic cells. , 1997, Journal of immunology.

[176]  B. Pulendran,et al.  Developmental pathways of dendritic cells in vivo: distinct function, phenotype, and localization of dendritic cell subsets in FLT3 ligand-treated mice. , 1997, Journal of immunology.

[177]  R. Germain,et al.  Antigen-unspecific B Cells and Lymphoid Dendritic Cells Both Show Extensive Surface Expression of Processed Antigen–Major Histocompatibility Complex Class II Complexes after Soluble Protein Exposure In Vivo or In Vitro , 1997, The Journal of experimental medicine.

[178]  Antonio Lanzavecchia,et al.  Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells , 1997, Nature.

[179]  R. Steinman,et al.  Developmental regulation of MHC class II transport in mouse dendritic cells , 1997, Nature.

[180]  C. Peters,et al.  Degradation of Mouse Invariant Chain: Roles of Cathepsins S and D and the Influence of Major Histocompatibility Complex Polymorphism , 1997, The Journal of experimental medicine.

[181]  G. Nolan,et al.  Introduction of soluble proteins into the MHC class I pathway by conjugation to an HIV tat peptide. , 1997, Journal of immunology.

[182]  J. Bonifacino,et al.  Linking cargo to vesicle formation: receptor tail interactions with coat proteins. , 1997, Current opinion in cell biology.

[183]  K. Shortman,et al.  Dendritic cell subtypes in mouse lymphoid organs: cross-correlation of surface markers, changes with incubation, and differences among thymus, spleen, and lymph nodes. , 1997, Journal of immunology.

[184]  A. Lanzavecchia,et al.  A Novel Inhibitory Receptor (ILT3) Expressed on Monocytes, Macrophages, and Dendritic Cells Involved in Antigen Processing , 1997, The Journal of experimental medicine.

[185]  A. Johnson,et al.  The Aqueous Pore through the Translocon Has a Diameter of 40–60 Å during Cotranslational Protein Translocation at the ER Membrane , 1997, Cell.

[186]  D. Klatzmann,et al.  Three populations of mouse lymph node dendritic cells with different origins and dynamics. , 1997, Journal of immunology.

[187]  B. Stockinger,et al.  Bone marrow-derived dendritic cells can process bacteria for MHC-I and MHC-II presentation to T cells. , 1997, Journal of immunology.

[188]  I. Mellman,et al.  Ii Chain Controls the Transport of Major Histocompatibility Complex Class II Molecules to and from Lysosomes , 1997, The Journal of cell biology.

[189]  Stephen Shaw,et al.  Cords, channels, corridors and conduits: critical architectural elements facilitating cell interactions in the lymph node cortex , 1997, Immunological reviews.

[190]  G. Hämmerling,et al.  HLA-DM acts as a molecular chaperone and rescues empty HLA-DR molecules at lysosomal pH. , 1997, Immunity.

[191]  G. Hämmerling,et al.  How HLA-DM edits the MHC class II peptide repertoire: survival of the fittest? , 1997, Immunology today.

[192]  Francesca Granucci,et al.  Maturation Stages of Mouse Dendritic Cells in Growth Factor–dependent Long-Term Cultures , 1997, The Journal of experimental medicine.

[193]  A. Prescott,et al.  Constitutive macropinocytosis allows TAP‐dependent major histocompatibility compex class I presentation of exogenous soluble antigen by bone marrow‐derived dendritic cells , 1997, European journal of immunology.

[194]  T. Rapoport,et al.  Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction , 1996, Nature.

[195]  A. Sant,et al.  DM-mediated release of a naturally occurring invariant chain degradation intermediate from MHC class II molecules. , 1996, Journal of immunology.

[196]  P. Cresswell,et al.  HLA-DM Interactions with Intermediates in HLA-DR Maturation and a Role for HLA-DM in Stabilizing Empty HLA-DR Molecules , 1996, The Journal of experimental medicine.

[197]  B. Jungnickel,et al.  Oligomeric Rings of the Sec61p Complex Induced by Ligands Required for Protein Translocation , 1996, Cell.

[198]  G. Malcherek,et al.  Human histocompatibility leukocyte antigen (HLA)-DM edits peptides presented by HLA-DR according to their ligand binding motifs , 1996, The Journal of experimental medicine.

[199]  G. Hämmerling,et al.  Editing of the HLA‐DR‐peptide repertoire by HLA‐DM. , 1996, The EMBO journal.

[200]  F. Castellino,et al.  Evidence that binding site occupancy is necessary and sufficient for effective major histocompatibility complex (MHC) class II transport through the secretory pathway redefines the primary function of class II-associated invariant chain peptides (CLIP) , 1996, The Journal of experimental medicine.

[201]  M. Moser,et al.  Regulation of dendritic cell numbers and maturation by lipopolysaccharide in vivo , 1996, The Journal of experimental medicine.

[202]  T. Watts,et al.  Effect of HLA-DM transfection on hen egg lysozyme presentation by T2.Ak cells. , 1996, Journal of immunology.

[203]  J. Yewdell,et al.  Defective ribosomal products (DRiPs): a major source of antigenic peptides for MHC class I molecules? , 1996, Journal of immunology.

[204]  F. Finkelman,et al.  Dendritic cells can present antigen in vivo in a tolerogenic or immunogenic fashion. , 1996, Journal of immunology.

[205]  P. Sopp,et al.  Afferent lymph veiled cells stimulate proliferative responses in allogeneic CD4+ and CD8+ T cells but not γδ TCR+ T cells , 1996, Immunology.

[206]  T. Tedder,et al.  Type I (CD64) and type II (CD32) Fc gamma receptor-mediated phagocytosis by human blood dendritic cells. , 1996, Journal of immunology.

[207]  C. Harding,et al.  Roles of proteasomes, transporter for antigen presentation (TAP), and beta 2-microglobulin in the processing of bacterial or particulate antigens via an alternate class I MHC processing pathway. , 1996, Journal of immunology.

[208]  G. Schuler,et al.  Human cutaneous dendritic cells migrate through dermal lymphatic vessels in a skin organ culture model. , 1996, The Journal of investigative dermatology.

[209]  P. A. Peterson,et al.  Antigen Presentation and T Cell Development in H2-M-Deficient Mice , 1996, Science.

[210]  H. Ruley,et al.  H2-M Mutant Mice Are Defective in the Peptide Loading of Class II Molecules, Antigen Presentation, and T Cell Repertoire Selection , 1996, Cell.

[211]  C. Benoist,et al.  Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC Class II Peptide-Loading Pathway , 1996, Cell.

[212]  R. Sékaly,et al.  Invariant chain protects class II histocompatibility antigens from binding intact polypeptides in the endoplasmic reticulum. , 1996, The EMBO journal.

[213]  N. Shastri,et al.  Class I MHC presentation of exogenous soluble antigen via macropinocytosis in bone marrow macrophages. , 1995, Immunity.

[214]  R. Germain,et al.  Major histocompatibility complex class I presentation of peptides derived from soluble exogenous antigen by a subset of cells engaged in phagocytosis , 1995, The Journal of experimental medicine.

[215]  H. Geuze,et al.  Transport from late endosomes to lysosomes, but not sorting of integral membrane proteins in endosomes, depends on the vacuolar proton pump , 1995, The Journal of cell biology.

[216]  F. Sallusto,et al.  Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products , 1995, The Journal of experimental medicine.

[217]  R. Steinman,et al.  The endocytic activity of dendritic cells , 1995, The Journal of experimental medicine.

[218]  Eric O Long,et al.  Antigen presentation mediated by recycling of surface HLA-DR molecules , 1995, Nature.

[219]  R. Steinman,et al.  The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing , 1995, Nature.

[220]  P. Cresswell,et al.  Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles , 1995, The Journal of experimental medicine.

[221]  R. Germain,et al.  Allelic differences affecting invariant chain dependency of MHC class II subunit assembly. , 1995, Immunity.

[222]  O. Bakke,et al.  Invariant Chain Induces a Delayed Transport from Early to Late Endosomes (*) , 1995, The Journal of Biological Chemistry.

[223]  C. Huh,et al.  Structural organization, expression and chromosomal mapping of the mouse cystatin-C-encoding gene (Cst3) , 1995, Gene.

[224]  H. Ploegh,et al.  How MHC class II molecules reach the endocytic pathway. , 1995, The EMBO journal.

[225]  C. Elias,et al.  The requirement for DM in class II-restricted antigen presentation and SDS-stable dimer formation is allele and species dependent , 1995, The Journal of experimental medicine.

[226]  A. Vitiello,et al.  The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes. , 1994, Journal of immunology.

[227]  P. L. Campbell,et al.  Antigen presentation and assembly by mouse I-Ak class II molecules in human APC containing deleted or mutated HLA DM genes. , 1994, Journal of immunology.

[228]  P. Cresswell,et al.  In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides. , 1994, Immunity.

[229]  R. Steinman,et al.  The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro , 1994, The Journal of experimental medicine.

[230]  D. Margulies,et al.  Determinant selection of major histocompatibility complex class I- restricted antigenic peptides is explained by class I-peptide affinity and is strongly influenced by nondominant anchor residues , 1994, The Journal of experimental medicine.

[231]  R. Germain,et al.  The CLIP region of invariant chain plays a critical role in regulating major histocompatibility complex class II folding, transport, and peptide occupancy , 1994, The Journal of experimental medicine.

[232]  C. Watts,et al.  Antigen processing and class II MHC peptide-loading compartments in human B-lymphoblastoid cells , 1994, Nature.

[233]  H. Ploegh,et al.  Isolation and characterization of the intracellular MHC class II compartment , 1994, Nature.

[234]  I. Mellman,et al.  Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes , 1994, Nature.

[235]  A. Wandinger-Ness,et al.  Separation of subcellular compartments containing distinct functional forms of MHC class II , 1994, The Journal of cell biology.

[236]  F. Sallusto,et al.  Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha , 1994, The Journal of experimental medicine.

[237]  M. Taylor,et al.  Endosomal aspartic proteinases are required for invariant-chain processing. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[238]  A. Sant,et al.  T cell receptor recognition of MHC class II alloantigens is highly cell type dependent. , 1994, Journal of immunology.

[239]  J. Bonifacino,et al.  Association with BiP and aggregation of class II MHC molecules synthesized in the absence of invariant chain. , 1994, The EMBO journal.

[240]  T. Schaffner,et al.  Phenotype of Langerhans cells in human afferent skin lymph derived from allergic contact dermatitis , 1993, Experimental dermatology.

[241]  Bernhard Dobberstein,et al.  The MHC class II-associated invariant chain contains two endosomal targeting signals within its cytoplasmic tail. , 1993, Journal of cell science.

[242]  H. Ploegh,et al.  Involvement of the vacuolar H(+)-ATPases in the secretory pathway of HepG2 cells. , 1993, The Journal of biological chemistry.

[243]  C. Sousa,et al.  Phagocytosis of antigens by Langerhans cells in vitro , 1993, The Journal of experimental medicine.

[244]  R. Germain,et al.  Peptide binding inhibits protein aggregation of invariant-chain free class II dimers and promotes surface expression of occupied molecules , 1993, Nature.

[245]  R. Steinman,et al.  Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor , 1992, The Journal of experimental medicine.

[246]  J. Neefjes,et al.  Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes. , 1992, The EMBO journal.

[247]  P. Möller,et al.  Rapid intracellular pathway gives rise to cell surface expression of the MHC class II-associated invariant chain (CD74). , 1991, Journal of immunology.

[248]  R. Germain,et al.  MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding , 1991, Nature.

[249]  G. Schuler,et al.  Class II major histocompatibility complex molecules of murine dendritic cells: synthesis, sialylation of invariant chain, and antigen processing capacity are down-regulated upon culture. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[250]  H. Geuze,et al.  Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments , 1991, Nature.

[251]  P. A. Peterson,et al.  Intracellular transport of class II MHC molecules directed by invariant chain , 1990, Nature.

[252]  O. Bakke,et al.  MHC class II-associated invariant chain contains a sorting signal for endosomal compartments , 1990, Cell.

[253]  R. Steinman,et al.  Antigen processing by epidermal Langerhans cells correlates with the level of biosynthesis of major histocompatibility complex class II molecules and expression of invariant chain , 1990, The Journal of experimental medicine.

[254]  R. Steinman,et al.  Migration and maturation of Langerhans cells in skin transplants and explants , 1990, The Journal of experimental medicine.

[255]  C. Watts,et al.  Cycling of cell-surface MHC glycoproteins through primaquine-sensitive intracellular compartments , 1990, Nature.

[256]  I. Olafsson,et al.  Structure and expression of the human cystatin C gene. , 1990, The Biochemical journal.

[257]  P. van Endert,et al.  Human major histocompatibility complex class II invariant chain is expressed on the cell surface. , 1990, The Journal of biological chemistry.

[258]  R. Steinman,et al.  Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells , 1989, The Journal of experimental medicine.

[259]  R. Feinman,et al.  Molecular and biochemical characterization of a novel gamma-interferon-inducible protein. , 1988, The Journal of biological chemistry.

[260]  R. Steinman,et al.  Quantitation of surface antigens on cultured murine epidermal Langerhans cells: rapid and selective increase in the level of surface MHC products. , 1988, The Journal of investigative dermatology.

[261]  S. Knight,et al.  Localization of antigen on lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate. Functional and morphological studies , 1987, The Journal of experimental medicine.

[262]  D. Stephany,et al.  Enhanced antigen-presenting capacity of cultured Langerhans' cells is associated with markedly increased expression of Ia antigen. , 1987, Journal of immunology.

[263]  R. Steinman,et al.  Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro , 1985, The Journal of experimental medicine.

[264]  J. Kaufman,et al.  Purification of HLA-linked B lymphocyte alloantigens in immunologically active form by preparative sodium dodecyl sulfate-gel electrophoresis and studies on their subunit association. , 1977, The Journal of biological chemistry.

[265]  M. Bevan.  Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay , 1976, The Journal of experimental medicine.

[266]  Bert van den Berg,et al.  X-ray structure of a protein-conducting channel , 2004, Nature.

[267]  Kees Jalink,et al.  Peptide diffusion, protection, and degradation in nuclear and cytoplasmic compartments before antigen presentation by MHC class I. , 2003, Immunity.

[268]  A. Goldberg,et al.  Protein degradation and the generation of MHC class I-presented peptides. , 2002, Advances in immunology.

[269]  H. Langen,et al.  Tetraspan microdomains distinct from lipid rafts enrich select peptide–MHC class II complexes , 2002, Nature Immunology.

[270]  R. Steinman.  Inaugural Article : avoiding horror autotoxicus. The importance of dendritic cells in peripheral T cell tolerance , 2002 .

[271]  J. V. Ravetch,et al.  IgG Fc receptors. , 2001, Annual review of immunology.

[272]  W. Heath,et al.  Cross-presentation, dendritic cells, tolerance and immunity. , 2001, Annual review of immunology.

[273]  J. Davoust,et al.  Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. , 2000, Immunity.

[274]  L. Karlsson,et al.  Nonclassical MHC class II molecules. , 2000, Annual review of immunology.

[275]  J. Yewdell,et al.  Mechanisms of exogenous antigen presentation by MHC class I molecules in vitro and in vivo: implications for generating CD8+ T cell responses to infectious agents, tumors, transplants, and vaccines. , 1999, Advances in immunology.

[276]  M. Mcgrath.  The lysosomal cysteine proteases. , 1999, Annual review of biophysics and biomolecular structure.

[277]  H. Chapman,et al.  Emerging roles for cysteine proteases in human biology. , 1997, Annual review of physiology.

[278]  C. Watts,et al.  Capture and processing of exogenous antigens for presentation on MHC molecules. , 1997, Annual review of immunology.

[279]  Dendritic Cells: Unique Leukocyte Populations Which Control the Primary , 1997 .

[280]  J. Trowsdale,et al.  Association between HLA-DM and HLA-DR in vivo. , 1996, Immunity.

[281]  T A Rapoport,et al.  Protein transport across the eukaryotic endoplasmic reticulum and bacterial inner membranes. , 1996, Annual review of biochemistry.

[282]  I. Mellman.  Endocytosis and molecular sorting. , 1996, Annual review of cell and developmental biology.

[283]  R. Germain,et al.  Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments. , 1995, Immunity.

[284]  H. Ploegh,et al.  How MHC class II molecules acquire peptide cargo: biosynthesis and trafficking through the endocytic pathway. , 1995, Annual review of cell and developmental biology.

[285]  V. Engelhard,et al.  Structure of peptides associated with class I and class II MHC molecules. , 1994, Annual review of immunology.

[286]  R. Steinman,et al.  The dendritic cell system and its role in immunogenicity. , 1991, Annual review of immunology.

[287]  C. Janeway.  Approaching the asymptote? Evolution and revolution in immunology. , 1989, Cold Spring Harbor symposia on quantitative biology.

[288]  B. Dutia,et al.  Edinburgh Explorer Characterization of sheep afferent lymph dendritic cells and their role in antigen carriage , 2022 .