The effects of selective caudate lesions in infant and juvenile Rhesus monkeys.

Summary Monkeys given selective caudate lesions in infancy were compared with monkeys given comparable lesions as juveniles on a variety of behavioral tests beginning 10 months after surgery. The monkeys operated upon in infancy were impaired on all of the tests on which the monkeys operated upon as juveniles were impaired, and to no less degree. The results underscore the importance of the site of injury in determining future recovery from brain damage, however early in life that damage occurs. The present results obtained in monkeys with caudate lesions were also compared with previous results on the effects of prefrontal cortical injury in infancy. The finding that the early caudate lesions impair exactly those functions that the early prefrontal lesions spare, led to the conclusion that the caudate nucleus becomes functional earlier in ontogeny than the cortex and can mediate the functions that the cortex will ultimately assume.

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