TUMOR‐LOCALIZING FLUORESCENT DIAGNOSTIC AGENTS WITHOUT PHOTOTOXICITY

In order to develop tumor‐localizing fluorescent diagnostic agents without phototoxicity, various heterodimers linked by some spacers between a chlorine derivative and its Mn or Cu complex were synthesized. The representative agent of them was named HAT‐D01 and has a molecular formula of m‐phthalyl‐{[13,17‐bispropanoic acid‐3‐ethenyl‐8‐formylethylidene‐7‐hydroxy‐2,7,12,18‐tetramethyl‐porphyrinate]‐manganese (III)}‐[3′‐ethenyl‐8′‐formylethylidene‐7′‐hydroxy‐2′,7′, 12′, 18′‐tetramethyl‐porphine‐13′, 17′‐bispropanoyl aspartic acid]‐bishydrazone.

[1]  T Takemura,et al.  THE MECHANISM OF PHOTOSENSITIZATION IN PHOTODYNAMIC THERAPY: CHEMILUMINESCENCE CAUSED BY PHOTOSENSITIZATION OF PORPHYRINS IN SALINE CONTAINING HUMAN SERUM ALBUMIN , 1992, Photochemistry and photobiology.

[2]  T. Dougherty,et al.  HOW DOES PHOTODYNAMIC THERAPY WORK? , 1992, Photochemistry and photobiology.

[3]  C. Gomer.  PRECLINICAL EXAMINATION OF FIRST and SECOND GENERATION PHOTOSENSITIZERS USED IN PHOTODYNAMIC THERAPY , 1991, Photochemistry and photobiology.

[4]  H. Nishino,et al.  PHOTOCYTOTOXICITY OF WATER‐SOLUBLE METALLOPORPHYRIN DERIVATIVES , 1993, Photochemistry and photobiology.

[5]  Isao Sakata,et al.  Synthesis, physicochemical properties and photocytotoxicity of five new δ-substituted chlorin e6 derivatives , 1990 .

[6]  N Ikeda,et al.  Photodynamic diagnosis in respiratory tract malignancy using an excimer dye laser system. , 1990, Journal of photochemistry and photobiology. B, Biology.

[7]  T Takemura,et al.  Detection and quantitative estimation of metalloporphyrins in vivo. , 1991, Journal of photochemistry and photobiology. B, Biology.

[8]  N. Ohta,et al.  CRITICAL IMPORTANCE OF THE TRIPLET LIFETIME OF PHOTOSENSITIZER IN PHOTODYNAMIC THERAPY OF TUMOR , 1989, Photochemistry and photobiology.

[9]  Takeshi Takemura,et al.  Kinetic study of triplet excimer formation in fluid solution by means of phosphorimetry , 1976 .

[10]  C. Foote.  DEFINITION OF TYPE I and TYPE II PHOTOSENSITIZED OXIDATION , 1991, Photochemistry and photobiology.

[11]  Kinichi Obi,et al.  Triplet-triplet energy transfer in a copper(II) porphyrin―free-base porphyrin dimer , 1987 .

[12]  O. Balchum,et al.  Fluorescence bronchoscopy for localization of carcinoma in situ. , 1983, Medical physics.

[13]  Y. Kubo,et al.  111In-labeled Mn-metalloporphyrin for tumor imaging. , 1993, Nuclear medicine and biology.

[14]  T Takemura,et al.  The tumour-localizing properties of porphyrin derivatives. , 1990, Journal of Photochemistry and Photobiology. B: Biology.

[15]  M. Namiki,et al.  Electrophysiological studies on the cultured cells obtained from transplantable pancreatic carcinoma in Syrian golden hamsters , 1984, Peptides.

[16]  W. Star,et al.  Tissue-localizing properties of some photosensitizers studied by in vivo fluorescence imaging. , 1990, Journal of photochemistry and photobiology. B, Biology.

[17]  T Takemura,et al.  THE MECHANISM OF PHOTOSENSITIZATION IN PHOTODYNAMIC THERAPY: PHOSPHORESCENCE BEHAVIOR OF PORPHYRIN DERIVATIVES IN SALINE SOLUTION CONTAINING HUMAN SERUM ALBUMIN , 1991, Photochemistry and photobiology.

[18]  J Moan,et al.  PHOTOCHEMOTHERAPY OF CANCER: EXPERIMENTAL RESEARCH , 1992, Photochemistry and photobiology.

[19]  Takeshi Takemura,et al.  Dynamical study of triplet-triplet energy transfer in rigid solution , 1977 .

[20]  Takeshi Takemura,et al.  A Kinetic Study of Dual Phosphorescence of Halogenated Benzenes in Rigid Glass Solution. , 1986 .