Abstract In this study, we investigated the antimicrobial activity of silver nanoparticles (Ag-NPs) and platinum nanoparticles (Pt-NPs) aqueous solution, which were prepared using different stabilizer, such as sodium dodecylsulfate (SDS) and poly-( N -vinyl-2-pyrrolidone) (PVP), for Staphylococcus aureus ( S. aureus ) and Escherichia coli ( E.coli ) by measuring the minimum inhibitory concentration (MIC). Antimicrobial effect of Ag-NPs for S. aureus and E. coli was investigated using cup diffusion method. The growth of Gram-positive ( S. aureus ) and Gram-negative ( E. coli ) bacteria were inhibited by Ag-NPs. The MIC of Ag-NPs for S. aureus and E. coli were 5 and 10 ppm, respectively. But the Au-NPs stabilized with SDS did not show antimicrobial activity. Also, the Pt-NPs stabilized with PVP (or SDS) did not show antimicrobial activity for the test organisms.
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