Anaesthesia for extracorporeal lithotripsy

thetics on drug metabolism and d i s p o s i t i ~ n . ~ ~ However, as we stated in our paper, although within study differences in fentanyl kinetics between healthy controls and surgical patients have been described, these did not explain our findings. For example, the normal volunteer studies quoted yielded values that were amongst both the highest and the lowest in our simulations. Thus, we remain convinced that there is considerable inconsistency in the plasma fentanyl concentrations which would be predicted from the various published studies describing fentanyl pharmacokinetics.