Testosterone promotion effect of Eucommia ulmoides staminate flower via the steroidogenic pathway and potential hormonal mechanism

[1]  Ying-Xia Zhao,et al.  UPLC‐MS analysis and network pharmacology‐based investigation into the active ingredients and molecular mechanisms of anti‐fatigue of male flowers with Eucommia ulmoides Oliv. , 2022, Fundamental & clinical pharmacology.

[2]  Jianying Wang,et al.  Phytochemical constituents, chemotaxonomic significance and anti-arthritic effect of Eucommia ulmoides Oliver staminate flowers , 2020, Natural product research.

[3]  Yangang Xing,et al.  Inhibition of Rheumatoid Arthritis Using Bark, Leaf, and Male Flower Extracts of Eucommia ulmoides , 2020, Evidence-based complementary and alternative medicine : eCAM.

[4]  Jinhua He,et al.  Antihypertensive Activity of Eucommia Ulmoides Oliv: Male Flower Extract in Spontaneously Hypertensive Rats , 2020, Evidence-based complementary and alternative medicine : eCAM.

[5]  Feifei Guo,et al.  [Research advances in chemical constituents and pharmacological activities of different parts of Eucommia ulmoides]. , 2020, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.

[6]  M. He,et al.  Doxorubicin Induces Endotheliotoxicity and Mitochondrial Dysfunction via ROS/eNOS/NO Pathway , 2020, Frontiers in Pharmacology.

[7]  Ashish Ranjan Sharma,et al.  Kaempferol stimulates WNT/β-catenin signaling pathway to induce differentiation of osteoblasts. , 2019, The Journal of nutritional biochemistry.

[8]  Guotao Sun,et al.  Comparative Evaluation of Hydrothermal Carbonization and Low Temperature Pyrolysis of Eucommia ulmoides Oliver for the Production of Solid Biofuel , 2019, Scientific Reports.

[9]  R. Shafiee‐Nick,et al.  Flavonoids for preserving pancreatic beta cell survival and function: A mechanistic review. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[10]  Jianying Wang,et al.  Anti-inflammatory effects of Eucommia ulmoides Oliv. male flower extract on lipopolysaccharide-induced inflammation , 2019, Chinese medical journal.

[11]  Juane Dong,et al.  Metabolite Profiles, Bioactivity, and HPLC Fingerprint of Different Varieties of Eucommia ulmoides Oliv.: Towards the Utilization of Medicinal and Commercial Chinese Endemic Tree , 2018, Molecules.

[12]  P. Giriwono,et al.  A novel function of geranylgeraniol in regulating testosterone production , 2018, Bioscience, biotechnology, and biochemistry.

[13]  B. Zirkin,et al.  Steroidogenesis in Leydig cells: effects of aging and environmental factors. , 2017, Reproduction.

[14]  Yong-feng Chen,et al.  Anti-atherosclerotic effect of geniposidic acid in a rabbit model and related cellular mechanisms , 2015, Pharmaceutical biology.

[15]  Xiao-yu Xing,et al.  [Generation and regulation of Leydig cells]. , 2014, Zhonghua nan ke xue = National journal of andrology.

[16]  D. Hao,et al.  Eucommia ulmoides Oliv.: ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine. , 2014, Journal of ethnopharmacology.

[17]  Kyung-Chul Choi,et al.  Anti-cancer Effect and Underlying Mechanism(s) of Kaempferol, a Phytoestrogen, on the Regulation of Apoptosis in Diverse Cancer Cell Models , 2013, Toxicological research.

[18]  Liu Haifang,et al.  Study on the sedative and hypnotic effects of water extracts of eucommia male flowers , 2013 .

[19]  B. Zirkin,et al.  Identification, proliferation, and differentiation of adult Leydig stem cells. , 2012, Endocrinology.

[20]  O. Söder,et al.  Origin, Development and Regulation of Human Leydig Cells , 2010, Hormone Research in Paediatrics.

[21]  L. Qin.  Regulation effects ofEucommia ulmoides male flower tea on lipid parameters of mice fed with high fat emul , 2009 .

[22]  P. Vanhoutte,et al.  Kaempferol stimulates large conductance Ca2+‐activated K+ (BKCa) channels in human umbilical vein endothelial cells via a cAMP/PKA‐dependent pathway , 2008, British journal of pharmacology.

[23]  R. Sharma,et al.  Isolation and culture of Leydig cells from adult rats , 2006, Indian Journal of Clinical Biochemistry.

[24]  L. Qian.  Study on Anti-fatigue Effects of Eucommia ulmoides Male Flower Tea on Mice , 2008 .

[25]  D. Choi,et al.  Flavonol glycosides from the leaves of Eucommia ulmoides O. with glycation inhibitory activity. , 2004, Journal of ethnopharmacology.

[26]  H. Ha,et al.  Effects of eucommiae cortex on osteoblast-like cell proliferation and osteoclast inhibition , 2003, Archives of pharmacal research.

[27]  Yuan-sheng Gao,et al.  Effects of SQ 22536, an adenylyl cyclase inhibitor, on isoproterenol-induced cyclic AMP elevation and relaxation in newborn ovine pulmonary veins. , 2002, European journal of pharmacology.

[28]  F. Labrie,et al.  Localization of Type 5 17β-Hydroxysteroid Dehydrogenase, 3β-Hydroxysteroid Dehydrogenase, and Androgen Receptor in the Human Prostate by in Situ Hybridization and Immunocytochemistry. , 1999, Endocrinology.

[29]  F. Labrie,et al.  Localization of type 5 17beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase, and androgen receptor in the human prostate by in situ hybridization and immunocytochemistry. , 1999, Endocrinology.

[30]  Edwin J. Routledge,et al.  Estrogenic activity of surfactants and some of their degradation products assessed using a recombinant yeast screen , 1996 .

[31]  M. Hagiwara,et al.  Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. , 1990, The Journal of biological chemistry.

[32]  K. Catt,et al.  Gonadotropin binding and stimulation of cyclic adenosine 3':5'-monophosphate and testosterone production in isolated Leydig cells. , 1975, The Journal of biological chemistry.