Genetic analysis of over one million people identifies 535 novel loci for blood pressure

High blood pressure is the foremost heritable global risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits to date (systolic, diastolic, pulse pressure) in over one million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also reveal shared loci influencing lifestyle exposures. Our findings offer the potential for a precision medicine strategy for future cardiovascular disease prevention.

Christian Gieger | Gonçalo Abecasis | He Gao | Uwe Völker | Andres Metspalu | Todd L Edwards | Alexander Teumer | Borbala Mifsud | Markus Perola | Archie Campbell | Marina Evangelou | Christopher Oldmeadow | Johan Sundström | Rodney J Scott | Roby Joehanes | Eric Boerwinkle | Vilmundur Gudnason | Igor Rudan | Lars Lind | Tamara B Harris | Alice Stanton | Simon Thom | Katarzyna Witkowska | Paolo Gasparini | Andrew P Morris | Kenneth Rice | Walter Palmas | Anubha Mahajan | Evangelos Evangelou | Francis Collins | Marcus Dörr | Nilesh J Samani | Andrew D. Johnson | Morris A Swertz | Harry Campbell | Murielle Bochud | Reedik Mägi | Francesco Cucca | Nicholas J Wareham | Kelly Cho | Christophe Tzourio | Ioanna Tzoulaki | Christopher J O'Donnell | Nabi Shah | Ulf Gyllensten | Jie Yao | Maris Laan | Caroline Hayward | Michael Boehnke | Ruifang Li-Gao | Peter Almgren | Vilmantas Giedraitis | Philippe Amouyel | Sekar Kathiresan | Claudia Langenberg | Renée de Mutsert | Erik Ingelsson | Eleftheria Zeggini | Anuj Goel | Ibrahim Karaman | Samuli Ripatti | Albert Hofman | Praveen Surendran | John Danesh | Adam S Butterworth | Veikko Salomaa | Cornelia M van Duijn | Paul Elliott | Aravinda Chakravarti | Annette Peters | Xiuqing Guo | Daniel Levy | Ayush Giri | Edith Hofer | André G Uitterlinden | Roberto Elosua | Seppo Koskinen | Terho Lehtimäki | Jaume Marrugat | Massimo Mangino | Mika Kähönen | Tonu Esko | Nick Shrine | Chiara Batini | Louise V Wain | Martin D Tobin | Franco Giulianini | Martin Farrall | Dorret I Boomsma | Gonneke Willemsen | Lenore J Launer | Joshua C Bis | Ganesh Chauhan | Stella Trompet | J Wouter Jukema | Paul Knekt | Yan V Sun | Sandosh Padmanabhan | Yan V. Sun | Teresa Nutile | Marina Ciullo | Peter J Munson | Jouke-Jan Hottenga | Helena Schmidt | Sara M. Willems | Elin Org | Stefan Enroth | John R Attia | Heather J Cordell | Michael R Barnes | Andrew D Johnson | Lorna M. Lopez | Evan Tzanis | Oscar H Franco | Harriëtte Riese | John C Chambers | Jaakko Tuomilehto | Bernard D Keavney | Mattias Frånberg | Kay-Tee Khaw | Ozren Polasek | Antti-Pekka Sarin | Joris Deelen | Michela Traglia | Ahmad Vaez | Christopher P Nelson | Tim D Spector | Jennifer E Huffman | Alanna C Morrison | Lili Milani | Guillaume Paré | Bruce M. Psaty | Elizabeth G Holliday | Anne-Claire Vergnaud | Paul M Ridker | Anders Hamsten | Pim van der Harst | Georgios Ntritsos | Olli T Raitakari | Veronique Vitart | Ivana Kolcic | Ian J Deary | Yong Qian | Denis C Shields | Robert A Scott | Peter P Pramstaller | Jonathan Marten | Najaf Amin | Yuri Milaneschi | Daniela Toniolo | Bram Prins | Teemu Niiranen | Zoltan Kutalik | Yasaman Saba | Rossella Sorice | Peter Vollenweider | Jian'an Luan | Antonietta Robino | Alan F Wright | Philip S Tsao | Edward G Lakatta | Paul F O'Reilly | Ilaria Gandin | Marjo-Riitta Jarvelin | Niki Dimou | P. O’Reilly | P. Elliott | M. Jarvelin | J. Danesh | M. Nalls | C. Gieger | O. Franco | A. Hofman | A. Uitterlinden | P. Tsao | T. Spector | D. Levy | A. Peters | I. Deary | L. Wain | N. Shrine | R. Mägi | E. Zeggini | A. Morris | D. Strachan | M. Tobin | G. Abecasis | K. Kristiansson | T. Lehtimäki | E. Boerwinkle | V. Salomaa | M. Perola | C. Lindgren | M. Laakso | F. Collins | Z. Kutalik | M. Boehnke | P. Ridker | D. Chasman | N. Samani | P. Braund | M. Mangino | Morris J. Brown | J. Connell | P. Munroe | M. Caulfield | M. Farrall | T. Ferreira | V. Gudnason | D. Conen | Albert Vernon Smith | A. Chakravarti | P. Munson | P. Wilson | Stefan Enroth | O. Raitakari | E. Lakatta | Shih-Jen Hwang | A. James | Yongmei Liu | B. Psaty | D. Siscovick | A. Stanton | S. Wild | M. Barnes | B. Penninx | G. Willemsen | R. Scott | D. Arking | S. Ripatti | A. Metspalu | T. Esko | L. Milani | E. Ingelsson | A. Jackson | J. Tuomilehto | A. Morris | A. Doney | S. Kathiresan | P. Almgren | C. Newton-Cheh | K. Taylor | J. Rotter | L. Lind | L. Risch | I. Karaman | A. Havulinna | P. Jousilahti | T. Harris | I. Rudan | D. Boomsma | E. D. de Geus | M. Swertz | A. Gow | A. Pattie | J. Starr | H. Cordell | P. Amouyel | N. Wareham | K. Rice | Antti-Pekka Sarin | A. Mahajan | J. Hottenga | C. Nelson | J. Deelen | A. Hamsten | C. V. van Duijn | A. Jula | A. Hung | Xiuqing Guo | J. Jukema | C. O’Donnell | C. Tzourio | H. Schmidt | A. Teumer | U. Völker | S. Harris | A. Wright | R. Elosua | H. Watkins | R. Joehanes | J. Bis | J. Gaziano | Borbala Mifsud | B. Oostra | S. Koskinen | J. Kooner | E. Bottinger | J. Howson | A. Morgan | G. Davies | D. Liewald | L. Lopez | N. Amin | C. Hayward | P. Joshi | I. Kolčić | C. Oldmeadow | O. Polašek | V. Vitart | J. Attia | H. Campbell | F. Cucca | E. Holliday | M. Kähönen | L. Launer | P. Vollenweider | James F. Wilson | C. Hartman | J. Marten | R. Noordam | A. Campbell | A. Goel | J. Luan | I. Nolte | S. Padmanabhan | A. Robino | R. Scott | P. J. van der Most | H. Warren | Weihua Zhang | Jinghua Zhao | M. Brumat | R. de Mutsert | G. Ehret | E. Evangelou | I. Gandin | He Gao | C. Langenberg | B. Lehne | Y. Milaneschi | N. Poulter | L. Rose | Jie Yao | J. Chambers | P. Gasparini | A. Oldehinkel | P. van der Harst | D. Mook-Kanamori | W. Palmas | A. Morrison | Jun Ding | G. Verwoert | B. Keavney | R. Loos | R. Strawbridge | C. Palmer | K. Khaw | Å. Johansson | L. Lyytikäinen | A. Hicks | M. Bochud | U. Gyllensten | P. Pramstaller | I. Tzoulaki | A. Butterworth | J. Jukema | D. Shields | G. Paré | J. Marrugat | M. Dörr | R. Rettig | G. Chauhan | S. Debette | S. Trompet | V. Giedraitis | C. Menni | D. Stott | J. Sundström | N. Verweij | M. Cocca | T. Edwards | A. Giri | G. Girotto | R. Li-Gao | P. Surendran | P. Knekt | P. Sever | R. Jansen | E. Org | M. Laan | C. Kovesdy | T. Boutin | N. Dimou | R. Pazoki | B. Prins | E. Hofer | S. Thériault | A. Vergnaud | D. Toniolo | H. Riese | Kelly Cho | D. V. Velez Edwards | C. Batini | T. Zemunik | M. Traglia | J. Huffman | J. Hellwege | A. Hung | T. Nutile | M. D. de Borst | C. Cabrera | M. Sargurupremraj | N. Shah | Andrew A. Hicks | Mattias Frånberg | J. Knight | Yong Qian | C. Sala | C. Barbieri | F. Giulianini | T. Niiranen | M. Ciullo | R. Sorice | D. Vuckovic | Ahmad Vaez | Andrew P. Morris | P. Nandakumar | K. Ayers | S. Thom | Y. Saba | S. Sõber | Wei-Yu Lin | L. Lin | M. 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Samani | David P. Strachan | A. Doney | C. A. Hartman | Nabi Shah | Peter Wf Wilson | Heather J Cordell | Janina S Reid | Christopher J. O'Donnell | A. Peters | Michael R Barnes | Sarah H Wild | C. Hartman | B. Penninx | Neil R. Poulter | J. Starr | Christopher J. O’Donnell | Georgios Ntritsos | L. Lin | Rodney J Scott | P. W. Wilson | Ruifang Li-Gao

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