Antibodies to Escherichia coli in chronic liver diseases.

Patients with chronic active hepatitis or alcoholic cirrhosis have serum antibodies to many more serotypes of Escherichia coli than do patients with primary biliary cirrhosis or cryptogenic cirrhosis, or normal controls. They also have antibodies against more serotypes than cirrhotic patients with a portacaval shunt. These observations suggest that factors other than shunting of blood away from the liver are responsible for the increased range of antibodies. These factors are discussed. There was no correlation between the number of serotypes to which antibodies were present and the serum immunoglobulin concentration. In three patients, each with chronic active hepatitis, the antibodies were predominantly of the IgM class, while the elevation of globulin in general was mainly due to increased IgG and IgA levels. Antibodies to Escherichia coli, therefore, probably contribute only a small part of the increased globulin levels found in patients with chronic liver disease.

[1]  J. Polak,et al.  Letter: Antral-gastrin-cell hyperplasia in peptic-ulcer disease. , 1974, Lancet.

[2]  J. Terblanche,et al.  Increased serum immunoglobulin levels following portacaval shunt in the normal rat , 1974, Gut.

[3]  B. Gazzard,et al.  Relation of renal impairment and haemorrhagic diathesis to endotoxaemia in fulminant hepatic failure. , 1974, Lancet.

[4]  G. Möller,et al.  Immunogenicity, tolerogenicity, and mitogenicity of lipopolysaccharides. , 1973, The Journal of infectious diseases.

[5]  R. Wright,et al.  Hyperglobulinaemia in liver disease. , 1973, Lancet.

[6]  H. Thomas,et al.  Role of the liver in controlling the immunogenicity of commensal bacteria in the gut. , 1973, Lancet.

[7]  H. Prytz,et al.  Antibodies to Escherichia coli in alcoholic and non-alcoholic patients with cirrhosis of the liver or fatty liver. , 1973, Scandinavian journal of gastroenterology.

[8]  R. Wright,et al.  Bacterial and dietary antibodies in liver disease. , 1972, Lancet.

[9]  H. Prytz,et al.  Antibodies to intestinal microbes in serum of patients with cirrhosis of the liver. , 1972, Lancet.

[10]  A. Allison.  Unresponsiveness to self antigens. , 1971, Lancet.

[11]  R. Soloway,et al.  Anti-Salmonella agglutinins in chronic active liver disease. , 1971, Lancet.

[12]  E. Cooke,et al.  Changing faecal population of escherichia coli in hospital medical patients , 1969, British medical journal.

[13]  C. Inchley.  The actvity of mouse Kupffer cells following intravenous injection of T4 bacteriophage. , 1969, Clinical and experimental immunology.

[14]  HARVEY M. CANTOR,et al.  Hepatic Suppression of Sensitization to Antigen absorbed into the Portal System , 1967, Nature.

[15]  J. G. Walker,et al.  Tissue antibodies in primary biliary cirrhosis, active chronic (lupoid) hepatitis, cryptogenic cirrhosis and other liver diseases and their clinical implications. , 1966, Clinical and experimental immunology.

[16]  J. Heremans,et al.  Immunochemical quantitation of antigens by single radial immunodiffusion. , 1965, Immunochemistry.

[17]  R. Schwartz,et al.  The immunoglobulin sequence. I. Arrest by 6-mercaptopurine and restitution by antibody, antigen or splenectomy. , 1965, Journal of immunology.

[18]  E. Howes,et al.  STUDIES OF HYPERIMMUNIZATION , 1965, Annals of the New York Academy of Sciences.

[19]  A. Percival,et al.  SERUM-ANTIBODY LEVELS AS AN INDICATION OF CLINICALLY INAPPARENT PYELONEPHRITIS. , 1964, Lancet.

[20]  J. Fahey,et al.  Relationship Between γ-Globulin Metabolism and Low Serum γ-Globulin in Germfree Mice , 1964, The Journal of Immunology.

[21]  S. Sell.  IMMUNOGLOBULINS OF THE GERMFREE GUINEA PIG. , 1964, Journal of immunology.

[22]  A. Braude,et al.  Studies with Radioactive Endotoxin. II. Correlation of Physiologic Effects with Distribution of Radioactivity in Rabbits Injected with Lethal Doses of E. Coli Endotoxin Labelled with Radioactive Sodium Chromate , 1955 .

[23]  E. Carlinfanti,et al.  Use of a tourniquet to prolong the effect of penicillin. , 1947, Lancet.