Strategy for a globally coordinated response to a priority neglected tropical disease: Snakebite envenoming

In one of his final essays, statesman and former United Nations secretary general Kofi Annan said, ‘Snakebite is the most important tropical disease you’ve never heard of’ [1]. Mr. Annan firmly believed that victims of snakebite envenoming should be recognised and afforded greater efforts at improved prevention, treatment, and rehabilitation. During the last years of his life, he advocated strongly for the World Health Organisation (WHO) and the global community to give greater priority to this disease of poverty and its victims.

[1]  N. Brown.  Consequences of Neglect: Analysis of the Sub-Saharan African Snake Antivenom Market and the Global Context , 2012, PLoS neglected tropical diseases.

[2]  F. Chappuis,et al.  Effectiveness of rapid transport of victims and community health education on snake bite fatalities in rural Nepal. , 2013, The American journal of tropical medicine and hygiene.

[3]  E. Bregani,et al.  Snake bites in Moyen Chari district, Chad: a five-year experience , 2011, Tropical doctor.

[4]  David J. Williams,et al.  The Need for Full Integration of Snakebite Envenoming within a Global Strategy to Combat the Neglected Tropical Diseases: The Way Forward , 2013, PLoS neglected tropical diseases.

[5]  M. Lewin,et al.  Varespladib (LY315920) Appears to Be a Potent, Broad-Spectrum, Inhibitor of Snake Venom Phospholipase A2 and a Possible Pre-Referral Treatment for Envenomation , 2016, Toxins.

[6]  David J. Williams,et al.  A multicomponent strategy to improve the availability of antivenom for treating snakebite envenoming. , 2014, Bulletin of the World Health Organization.

[7]  M. Nichter,et al.  Implementation of a decentralized community-based treatment program to improve the management of Buruli ulcer in the Ouinhi district of Benin, West Africa , 2018, PLoS neglected tropical diseases.

[8]  A. Abajobir,et al.  Mortality and Disability-Adjusted Life-Years (Dalys) for Common Neglected Tropical Diseases in Ethiopia, 1990-2015: Evidence from the Global Burden of Disease Study 2015. , 2017, Ethiopian medical journal.

[9]  Carl E. Taylor,et al.  Comprehensive review of the evidence regarding the effectiveness of community–based primary health care in improving maternal, neonatal and child health: 8. summary and recommendations of the Expert Panel , 2017, Journal of global health.

[10]  K. de Balogh,et al.  The Road to Dog Rabies Control and Elimination—What Keeps Us from Moving Faster? , 2017, Front. Public Health.

[11]  David J. Williams,et al.  Snakebite envenoming , 2017, Nature Reviews Disease Primers.

[12]  D. Lalloo,et al.  Snake Envenoming: A Disease of Poverty , 2009, PLoS neglected tropical diseases.

[13]  T. A. Okeke.  IMPROVING MALARIA RECOGNITION, TREATMENT AND REFERRAL PRACTICES BY TRAINING CARETAKERS IN RURAL NIGERIA , 2009, Journal of Biosocial Science.

[14]  W. Perea,et al.  A second affordable oral cholera vaccine: implications for the global vaccine stockpile. , 2016, The Lancet. Global health.

[15]  J. Gutiérrez,et al.  Peptidomimetic hydroxamate metalloproteinase inhibitors abrogate local and systemic toxicity induced by Echis ocellatus (saw‐scaled) snake venom , 2017, Toxicon : official journal of the International Society on Toxinology.

[16]  J. Chippaux,et al.  Snake-bites: appraisal of the global situation. , 1998, Bulletin of the World Health Organization.

[17]  S. Brooker,et al.  Modelling the distribution and transmission intensity of lymphatic filariasis in sub-Saharan Africa prior to scaling up interventions: integrated use of geostatistical and mathematical modelling , 2015, Parasites & Vectors.

[18]  Xiaonong Zhou,et al.  Building a global schistosomiasis alliance: an opportunity to join forces to fight inequality and rural poverty , 2017, Infectious Diseases of Poverty.

[19]  D. Belcher,et al.  Protocol and monitoring to improve snake bite outcomes in rural Ghana. , 2004, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[20]  S. Desai,et al.  Achievements and challenges for the use of killed oral cholera vaccines in the global stockpile era , 2017, Human vaccines & immunotherapeutics.

[21]  A. Habib,et al.  The snakebite problem and antivenom crisis from a health‐economic perspective , 2018, Toxicon : official journal of the International Society on Toxinology.

[22]  T. Lancet.  Snake-bite envenoming: a priority neglected tropical disease , 2017, The Lancet.

[23]  David J. Williams.  Snake bite: a global failure to act costs thousands of lives each year , 2015, BMJ : British Medical Journal.

[24]  M. Malecela,et al.  The role of community participation for sustainable integrated neglected tropical diseases and water, sanitation and hygiene intervention programs: A pilot project in Tanzania , 2018, Social science & medicine.

[25]  David J. Williams,et al.  Ending the drought: new strategies for improving the flow of affordable, effective antivenoms in Asia and Africa. , 2011, Journal of proteomics.

[26]  M. Nichter,et al.  Developing a Buruli ulcer community of practice in Bankim, Cameroon: A model for Buruli ulcer outreach in Africa , 2018, PLoS neglected tropical diseases.

[27]  F. Chappuis,et al.  Antivenoms for Snakebite Envenoming: What Is in the Research Pipeline? , 2015, PLoS neglected tropical diseases.

[28]  S. Brooker,et al.  Association between Footwear Use and Neglected Tropical Diseases: A Systematic Review and Meta-Analysis , 2014, PLoS neglected tropical diseases.

[29]  J. Gutiérrez,et al.  Current technology for the industrial manufacture of snake antivenoms , 2018, Toxicon : official journal of the International Society on Toxinology.

[30]  David J. Williams,et al.  A Call for Incorporating Social Research in the Global Struggle against Snakebite , 2015, PLoS neglected tropical diseases.

[31]  K. Bardosh,et al.  Global aspirations, local realities: the role of social science research in controlling neglected tropical diseases , 2014, Infectious Diseases of Poverty.

[32]  Zafar Mirza,et al.  Strengthening health systems for universal health coverage and sustainable development , 2017, Bulletin of the World Health Organization.

[33]  R. Cumming,et al.  Why snakebite patients in Myanmar seek traditional healers despite availability of biomedical care at hospitals? Community perspectives on reasons , 2018, PLoS neglected tropical diseases.

[34]  D. Warrell,et al.  Crisis in snake antivenom supply for Africa , 2000, The Lancet.

[35]  G. Cecchi,et al.  Monitoring the elimination of human African trypanosomiasis: Update to 2014 , 2017, PLoS neglected tropical diseases.

[36]  Lin Ai,et al.  Surveillance-response systems: the key to elimination of tropical diseases , 2014, Infectious Diseases of Poverty.

[37]  J. Chippaux.  Snakebite envenomation turns again into a neglected tropical disease! , 2017, Journal of Venomous Animals and Toxins including Tropical Diseases.

[38]  U. Ekpo,et al.  Public Awareness and Knowledge of Neglected Tropical Diseases (NTDs) Control Activities in Abuja, Nigeria , 2014, PLoS neglected tropical diseases.

[39]  S. Swaroop.,et al.  Snakebite mortality in the world. , 1954, Bulletin of the World Health Organization.

[40]  A. Kasturiratne,et al.  The Global Burden of Snakebite: A Literature Analysis and Modelling Based on Regional Estimates of Envenoming and Deaths , 2008, PLoS medicine.

[41]  D. Tribble,et al.  Self-reported incidence of snake, spider, and scorpion encounters among deployed U.S. military in Iraq and Afghanistan. , 2007, Military medicine.

[42]  J. Gutiérrez,et al.  Confronting the Neglected Problem of Snake Bite Envenoming: The Need for a Global Partnership , 2006, PLoS medicine.

[43]  Sanjib K. Sharma,et al.  Protection against snake bites by sleeping under a bed net in southeastern Nepal. , 2007, The American journal of tropical medicine and hygiene.

[44]  A. Fahrion,et al.  Difficulties in estimating the human burden of canine rabies , 2017, Acta tropica.