Characterization and in vivo evaluation of sol-gel derived hydroxyapatite coatings on Ti6Al4V substrates.

Hydroxyapatite (HAP) based coatings on titanium alloy Ti6Al4V were attempted by sol-gel process. Precursor sol was dip-coated onto the substrates and the formation of HAP as the main phase was ensured after the sintering of coatings at 900 degrees C, as confirmed by the characterization studies involving XRD, FT-IR, Raman, and SEM-EDXS analysis. The biocompatibility of HAP-based coated titanium implants was tested by implantation studies in rabbit's tibia for a period of 8 weeks. Bone remodelling and inflammatory responses of the implants were studied during the implantation period. The better tissue-implant interaction of the coated implants with respect to the uncoated implants was observed after a defect healing period of 8 weeks. A coated implant with no evidence of rejection is a further advantage of the sol-gel derived HAP coating.

[1]  José M.F. Ferreira,et al.  Effect of Ca/P ratio of precursors on the formation of different calcium apatitic ceramics—An X-ray diffraction study , 2005 .

[2]  Antonios G Mikos,et al.  Methods: a comparative analysis of radiography, microcomputed tomography, and histology for bone tissue engineering. , 2005, Tissue engineering.

[3]  Y. Koyama,et al.  Bone Repair Analysis in a Novel Biodegradable Hydroxyapatite/Collagen Composite Implanted in Bone , 2005, Implant dentistry.

[4]  S. Kannan,et al.  In Situ Formation and Characterization of Flourine-Substituted Biphasic Calcium Phosphate Ceramics of Varied F-HAP/β-TCP Ratios , 2005 .

[5]  Jun Yao,et al.  The effect of bioactive glass content on synthesis and bioactivity of composite poly (lactic-co-glycolic acid)/bioactive glass substrate for tissue engineering. , 2005, Biomaterials.

[6]  J. Moradian-Oldak,et al.  Control of apatite crystal growth in a fluoride containing amelogenin-rich matrix. , 2005, Biomaterials.

[7]  Hyoun‐Ee Kim,et al.  Strontium substituted calcium phosphate biphasic ceramics obtained by a powder precipitation method , 2004, Journal of materials science. Materials in medicine.

[8]  H. Uchida,et al.  Development of porous ceramics with well-controlled porosities and pore sizes from apatite fibers and their evaluations , 2004, Journal of materials science. Materials in medicine.

[9]  Hyoun‐Ee Kim,et al.  Hydroxyapatite coating on titanium substrate with titania buffer layer processed by sol-gel method. , 2004, Biomaterials.

[10]  C. Betzel,et al.  Synthesis of stoichiometric nano crystalline hydroxyapatite by ethanol-based sol–gel technique at low temperature , 2004 .

[11]  S. Hajdu,et al.  Hydroxyapatite Cement (HAC) to Repair Cortical Defects in Long Bones - An Animal Study , 2004 .

[12]  P. Revell,et al.  A preliminary study on the enhancement of the osteointegration of a novel synthetic hydroxyapatite scaffold in vivo. , 2003, Journal of biomedical materials research. Part A.

[13]  T. Chin,et al.  FTIR, XRD, SEM and solid state NMR investigations of carbonate-containing hydroxyapatite nano-particles synthesized by hydroxide-gel technique , 2003 .

[14]  D. Uskoković,et al.  Surface Properties of HAp Particles Obtained by Hydrothermal Decomposition of Urea and Calcium-EDTA Chelates , 2002 .

[15]  S. Wunder,et al.  The role of surface functional groups in calcium phosphate nucleation on titanium foil: a self-assembled monolayer technique. , 2002, Biomaterials.

[16]  Cláudia de Carvalho Lopes,et al.  Bone remodeling analysis after placement of dental implants using polyfluorochrome sequential labeling. , 2002 .

[17]  G. Shen,et al.  Low temperature preparation of hydroxyapatite coatings on titanium alloy by a sol-gel route , 2000 .

[18]  G. Kmita,et al.  FTIR absorption–reflection study of biomimetic growth of phosphates on titanium implants , 2000 .

[19]  M. Takagi,et al.  The role of β-tricalcium phosphate in vascularized periosteum , 2000 .

[20]  D. Toonder,et al.  The effect of friction on scratch adhesion testing : application to a sol-gel coating on polypropylene , 2000 .

[21]  K. Itatani,et al.  Characterization of hydroxyapatite powders prepared by ultrasonic spray-pyrolysis technique , 1999 .

[22]  A. Jillavenkatesa,et al.  Sol–gel processing of hydroxyapatite , 1998 .

[23]  E. Munting.  The contributions and limitations of hydroxyapatite coatings to implant fixation , 1996, International Orthopaedics.

[24]  J. Ricci,et al.  A new canine model to evaluate the biological response of intramedullary bone to implant materials and surfaces. , 1990, Journal of biomedical materials research.

[25]  A. Durán,et al.  Protective glass coatings on metallic substrates , 1990 .

[26]  K. Donath,et al.  A method for the study of undecalcified bones and teeth with attached soft tissues. The Säge-Schliff (sawing and grinding) technique. , 1982, Journal of oral pathology.

[27]  H. Varma,et al.  Synthesis of calcium phosphate bioceramics by citrate gel pyrolysis method , 2005 .

[28]  D. Choi,et al.  Nanostructured calcium phosphates for biomedical applications: novel synthesis and characterization. , 2005, Acta biomaterialia.

[29]  C. Ohtsuki,et al.  Spray Pyrolysis Preparation of Apatite-Composite Particles for Biological Application , 1997 .

[30]  M. Yoshimura,et al.  Hydrothermal synthesis of biocompatible whiskers , 1994, Journal of Materials Science.

[31]  C. Brinker.  Sol-gel science , 1990 .

[32]  K. Donath,et al.  A method for the study of undecalcified bones and teeth with attached soft tissues. The sawing and grinding technique , 1982 .

[33]  H. Hansson,et al.  Osseointegrated titanium implants. Requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man. , 1981, Acta orthopaedica Scandinavica.

[34]  B. O. Fowler.  Infrared studies of apatites. I. Vibrational assignments for calcium, strontium, and barium hydroxyapatites utilizing isotopic substitution , 1974 .