Uncoupling the Mitogenic and Metabolic Functions of FGF1 by Tuning FGF1-FGF Receptor Dimer Stability.

[1]  M. Mohammadi,et al.  Regulation of Receptor Binding Specificity of FGF9 by an Autoinhibitory Homodimerization. , 2017, Structure.

[2]  Yi Xue,et al.  Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity , 2015, Cell.

[3]  J. M. Suh,et al.  Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer , 2014, Nature.

[4]  M. Mohammadi,et al.  Exploring mechanisms of FGF signalling through the lens of structural biology , 2013, Nature Reviews Molecular Cell Biology.

[5]  J. M. Suh,et al.  A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis , 2012, Nature.

[6]  Masashi Suzuki,et al.  Sulfated Glycosaminoglycans Are Required for Specific and Sensitive Fibroblast Growth Factor (FGF) 19 Signaling via FGF Receptor 4 and betaKlotho* , 2011, The Journal of Biological Chemistry.

[7]  N. Itoh,et al.  Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease. , 2011, Journal of biochemistry.

[8]  B. Lemon,et al.  Separating mitogenic and metabolic activities of fibroblast growth factor 19 (FGF19) , 2010, Proceedings of the National Academy of Sciences.

[9]  Richard A. Lang,et al.  Differential Interactions of FGFs with Heparan Sulfate Control Gradient Formation and Branching Morphogenesis , 2009, Science Signaling.

[10]  M. Hatakeyama,et al.  Structural and Functional Basis of a Role for CRKL in a Fibroblast Growth Factor 8-Induced Feed-Forward Loop , 2009, Molecular and Cellular Biology.

[11]  M. Mohammadi,et al.  The FGF family: biology, pathophysiology and therapy , 2009, Nature Reviews Drug Discovery.

[12]  J. Xu,et al.  FGF21 N‐ and C‐termini play different roles in receptor interaction and activation , 2009, FEBS letters.

[13]  Masashi Suzuki,et al.  betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. , 2008, Molecular endocrinology.

[14]  S. Kliewer,et al.  Tissue-specific Expression of βKlotho and Fibroblast Growth Factor (FGF) Receptor Isoforms Determines Metabolic Activity of FGF19 and FGF21* , 2007, Journal of Biological Chemistry.

[15]  K. Rosenblatt,et al.  βKlotho is required for metabolic activity of fibroblast growth factor 21 , 2007, Proceedings of the National Academy of Sciences.

[16]  S. Kliewer,et al.  Molecular Insights into the Klotho-Dependent, Endocrine Mode of Action of Fibroblast Growth Factor 19 Subfamily Members , 2007, Molecular and Cellular Biology.

[17]  K. Okawa,et al.  Klotho converts canonical FGF receptor into a specific receptor for FGF23 , 2006, Nature.

[18]  Shaun K Olsen,et al.  Receptor Specificity of the Fibroblast Growth Factor Family , 2006, Journal of Biological Chemistry.

[19]  T. Willson,et al.  Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[20]  A. Joyner,et al.  Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain. , 2006, Genes & development.

[21]  J. Gromada,et al.  FGF-21 as a novel metabolic regulator. , 2005, The Journal of clinical investigation.

[22]  Shaun K Olsen,et al.  Structural basis for fibroblast growth factor receptor activation. , 2005, Cytokine & growth factor reviews.

[23]  V. P. Eswarakumar,et al.  Cellular signaling by fibroblast growth factor receptors. , 2005, Cytokine & growth factor reviews.

[24]  D. Ambrosetti,et al.  Mechanisms underlying differential responses to FGF signaling. , 2005, Cytokine & growth factor reviews.

[25]  Nobuyuki Itoh,et al.  Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities. , 2004, Human molecular genetics.

[26]  Joseph Schlessinger,et al.  SH2 and PTB Domains in Tyrosine Kinase Signaling , 2003, Science's STKE.

[27]  M. Mohammadi,et al.  Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[28]  P. Rudland,et al.  Fibroblast growth factor-2 binds to small heparin-derived oligosaccharides and stimulates a sustained phosphorylation of p42/44 mitogen-activated protein kinase and proliferation of rat mammary fibroblasts. , 2002, The Biochemical journal.

[29]  C. Kahn,et al.  Insulin signalling and the regulation of glucose and lipid metabolism , 2001, Nature.

[30]  A. Joyner,et al.  Otx2, Gbx2 and Fgf8 interact to position and maintain a mid-hindbrain organizer. , 2000, Current opinion in cell biology.

[31]  J. Schlessinger,et al.  Cell Signaling by Receptor Tyrosine Kinases , 2000, Cell.

[32]  J. Schlessinger,et al.  Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization. , 2000, Molecular cell.

[33]  Joseph Schlessinger,et al.  Crystal Structures of Two FGF-FGFR Complexes Reveal the Determinants of Ligand-Receptor Specificity , 2000, Cell.

[34]  H. Larsson,et al.  Fibroblast Growth Factor Receptor-1-mediated Endothelial Cell Proliferation Is Dependent on the Src Homology (SH) 2/SH3 Domain-containing Adaptor Protein Crk* , 1999, The Journal of Biological Chemistry.

[35]  D. Bar-Sagi,et al.  A Lipid-Anchored Grb2-Binding Protein That Links FGF-Receptor Activation to the Ras/MAPK Signaling Pathway , 1997, Cell.

[36]  C. MacArthur,et al.  Receptor Specificity of the Fibroblast Growth Factor Family* , 1996, The Journal of Biological Chemistry.

[37]  M. Jaye,et al.  Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction , 1996, Molecular and cellular biology.

[38]  A. Rapak,et al.  Stimulation of proliferation of a human osteosarcoma cell line by exogenous acidic fibroblast growth factor requires both activation of receptor tyrosine kinase and growth factor internalization , 1996, Molecular and cellular biology.

[39]  Y. Li,et al.  Cell transformation by fibroblast growth factors can be suppressed by truncated fibroblast growth factor receptors. , 1994, Molecular and cellular biology.

[40]  E. Nabel,et al.  Recombinant fibroblast growth factor-1 promotes intimal hyperplasia and angiogenesis in arteries in vivo , 1993, Nature.

[41]  P. Månsson,et al.  Heparin-binding growth factor type 1 (acidic fibroblast growth factor): a potential biphasic autocrine and paracrine regulator of hepatocyte regeneration. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[42]  M. Mohammadi,et al.  The structural biology of the FGF19 subfamily. , 2012, Advances in experimental medicine and biology.