Intracerebellar conditioning — Brogden and Gantt revisited

In 1942, Brogden and Gantt reported that electrical stimulation of cerebellar white matter elicited specific behavioral responses (limb flexion, eyeblink, etc.) and that these movements so elicited could easily be conditioned to a neural tone CS, using standard Pavlovian procedures. This early evidence for the key role of the cerebellum in learning of discrete movements has in recent years been replicated and much extended. It is now clear that the cerebellum is the essential structure for associative learning of discrete movements elicited by peripheral aversive or intracerebellar stimuli and that the memory traces so formed are stored in the cerebellum.

[1]  Masao Ito,et al.  Climbing fibre induced depression of both mossy fibre responsiveness and glutamate sensitivity of cerebellar Purkinje cells , 1982, The Journal of physiology.

[2]  R. F. Thompson,et al.  Classical conditioning using stimulation of the inferior olive as the unconditioned stimulus. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[3]  R. F. Thompson,et al.  Neuronal responses of the rabbit cerebellum during acquisition and performance of a classically conditioned nictitating membrane-eyelid response , 1984, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[4]  R. F. Thompson,et al.  Unilateral inferior olive NMDA lesion leads to unilateral deficit in acquisition and retention of eyelid classical conditioning. , 1994, Behavioral and neural biology.

[5]  Richard F. Thompson,et al.  Lesions of the inferior olivary complex cause extinction of the classically conditioned eyeblink response , 1985, Brain Research.

[6]  R. B. Loucks,et al.  The Experimental Delimitation of Neural Structures Essential for Learning: The Attempt to Condition Striped Muscle Responses with Faradization of the Sigmoid Gyri , 1935 .

[7]  J. Albus.  A Theory of Cerebellar Function , 1971 .

[8]  D J Krupa,et al.  Inactivation of brainstem motor nuclei blocks expression but not acquisition of the rabbit's classically conditioned eyeblink response. , 1996, Behavioral neuroscience.

[9]  R. F. Thompson,et al.  Classical conditioning in rabbits using pontine nucleus stimulation as a conditioned stimulus and inferior olive stimulation as an unconditioned stimulus , 1989, Synapse.

[10]  D J Krupa,et al.  Inactivation of the superior cerebellar peduncle blocks expression but not acquisition of the rabbit's classically conditioned eye-blink response. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[11]  R. F. Thompson,et al.  Organization of memory traces in the mammalian brain. , 1994, Annual review of neuroscience.

[12]  Richard F. Thompson,et al.  Localization of a memory trace in the mammalian brain. , 1993, Science.

[13]  G. A. Clark,et al.  Initial localization of the memory trace for a basic form of learning. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[14]  Masao Ito.  The Cerebellum And Neural Control , 1984 .

[15]  W. Brogden,et al.  INTRANEURAL CONDITIONING: CEREBELLAR CONDITIONED REFLEXES , 1942 .

[16]  J. Steinmetz,et al.  Dorsal accessory inferior olive activity diminishes during acquisition of the rabbit classically conditioned eyelid response , 1991, Brain Research.

[17]  R. Clark,et al.  Reversible lesions of the cerebellar interpositus nucleus during acquisition and retention of a classically conditioned behavior. , 1992, Behavioral neuroscience.

[18]  Richard E Thompson,et al.  Cerebellar circuits and synaptic mechanisms involved in classical eyeblink conditioning , 1997, Trends in Neurosciences.

[19]  R. F. Thompson,et al.  Mammalian brain substrates of aversive classical conditioning. , 1993, Annual review of psychology.

[20]  A. F. Nordholm,et al.  Lidocaine infusion in a critical region of cerebellum completely prevents learning of the conditioned eyeblink response. , 1993, Behavioral neuroscience.

[21]  M. M. Patterson,et al.  Neuronal unit activity in the abducens nucleus during classical conditioning of the nictitating membrane response in the rabbit (Oryctolagus cuniculus). , 1979, Journal of comparative and physiological psychology.

[22]  M. Ito,et al.  Neural design of the cerebellar motor control system. , 1972, Brain research.

[23]  D. Linden,et al.  Long-term synaptic depression. , 1995, Annual review of neuroscience.

[24]  T. Voneida,et al.  Changes in instrumentally and classically conditioned limb-flexion responses following inferior olivary lesions and olivocerebellar tractotomy in the cat , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[25]  R. F. Thompson,et al.  Effect of kainic acid lesions of the cerebellar interpositus nucleus on eyelid conditioning in the rabbit , 1985, Brain Research.

[26]  D J Krupa,et al.  Reversible inactivation of the cerebellar interpositus nucleus completely prevents acquisition of the classically conditioned eye-blink response. , 1997, Learning & memory.

[27]  J. Delafresnaye,et al.  Brain mechanisms and learning , 1961 .

[28]  J. Sprague,et al.  Progress in physiological psychology , 1966 .

[29]  P. Strata.  The Olivocerebellar system in motor control , 1989 .

[30]  R. Rescorla.  Pavlovian conditioned inhibition , 1969 .

[31]  R. F. Thompson,et al.  Hippocampus and trace conditioning of the rabbit's classically conditioned nictitating membrane response. , 1986, Behavioral neuroscience.

[32]  R. F. Thompson,et al.  Cerebellar stimulation as an unconditioned stimulus in classical conditioning. , 1992, Behavioral neuroscience.

[33]  R Llinás,et al.  The cerebellum, LTD, and memory: alternative views. , 1997, Learning & memory.

[34]  A R Wagner,et al.  Conditioning with electrical stimulation of motor cortex: evidence of a possible source of motivation. , 1967, Journal of comparative and physiological psychology.

[35]  J. Eccles.  An instruction-selection theory of learning in the cerebellar cortex , 1977, Brain Research.

[36]  Richard F. Thompson,et al.  Hippocampectomy impairs the memory of recently, but not remotely, acquired trace eyeblink conditioned responses. , 1995, Behavioral neuroscience.

[37]  S. Bao,et al.  Impaired classical eyeblink conditioning in cerebellar-lesioned and Purkinje cell degeneration (pcd) mutant mice , 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[38]  W T Thach,et al.  The cerebellum and the adaptive coordination of movement. , 1992, Annual review of neuroscience.

[39]  Richard F. Thompson,et al.  Classical Conditioning With Electrical Stimulation of Cerebellum as Both Conditioned and Unconditioned Stimulus , 1996 .

[40]  J. Theios,et al.  Acquisition and extinction of a classically conditioned response in hippocampectomized rabbits (Oryctolagus cuniculus). , 1972, Journal of comparative and physiological psychology.

[41]  Professor Dr. John C. Eccles,et al.  The Cerebellum as a Neuronal Machine , 1967, Springer Berlin Heidelberg.

[42]  Jeffrey S. Grethe,et al.  Essential Neuronal Pathways for Reflex and Conditioned Response Initiation in an Intracerebellar Stimulation Paradigm and the Impact of Unconditioned Stimulus Preexposure on Learning Rate , 1999, Neurobiology of Learning and Memory.

[43]  D. Marr.  A theory of cerebellar cortex , 1969, The Journal of physiology.

[44]  R F Thompson,et al.  Memory systems in the brain and localization of a memory. , 1996, Proceedings of the National Academy of Sciences of the United States of America.