Acute Kidney Injury With Buffered Crystalloids vs Saline Among ICU Patients.

meaning of FDA approval. Physicians tended to overestimate the minimum evidence of efficacy required of new drugs. Similarly, many misinterpreted the term breakthrough—believing these drugs were supported by stronger evidence than required by the statute. Our results are limited by social desirability and other inherent survey response biases and may not be generalizable beyond internists and medical specialists. The misconceptions identified may lead physicians to overprescribe newly approved drugs—particularly breakthrough therapies— and inadequately communicate how well these drugs work to the patients who will use them.