Modeling of the temporal effects of heating during infrared neural stimulation

Abstract. A model of infrared neural stimulation (INS) has been developed to allow the temporal characteristics of different stimulation parameters and geometries to be better understood. The model uses a finite element approach to solve the heat equation and allow detailed analysis of heat during INS with both microsecond and millisecond laser pulses. When compared with experimental data, the model provides insight into the mechanisms behind INS. In particular, the analysis suggests that there may be two broad regimes of INS: the process tends to be limited by the total pulse energy for pulse lengths below 100 μs, while the temperature gradient with respect to time becomes more important above 100 μs.

[1]  Stephen J. O'Leary,et al.  Combined application of brain-derived neurotrophic factor and neurotrophin-3 and its impact on spiral ganglion neuron firing properties and hyperpolarization-activated currents , 2012, Hearing Research.

[2]  C. Richter,et al.  Spread of cochlear excitation during stimulation with pulsed infrared radiation: inferior colliculus measurements , 2011, Journal of neural engineering.

[3]  Joseph T. Walsh,et al.  Optical stimulation of auditory neurons: Effects of acute and chronic deafening , 2008, Hearing Research.

[4]  Joseph T. Walsh,et al.  Optical Parameter Variability in Laser Nerve Stimulation: A Study of Pulse Duration, Repetition Rate, and Wavelength , 2007, IEEE Transactions on Biomedical Engineering.

[5]  Claus-Peter Richter,et al.  Neural stimulation with optical radiation , 2011, Laser & photonics reviews.

[6]  Claus-Peter Richter,et al.  Acoustic Events and “Optophonic” Cochlear Responses Induced by Pulsed Near-Infrared LASER , 2011, IEEE Transactions on Biomedical Engineering.

[7]  Emmanuelle S. Albert,et al.  TRPV4 channels mediate the infrared laser-evoked response in sensory neurons. , 2012, Journal of neurophysiology.

[8]  Frank P. Incropera,et al.  Fundamentals of Heat and Mass Transfer , 1981 .

[9]  Anita Mahadevan-Jansen,et al.  Biophysical mechanisms of transient optical stimulation of peripheral nerve. , 2007, Biophysical journal.

[10]  Li-Ming Su,et al.  Noncontact stimulation of the cavernous nerves in the rat prostate using a tunable-wavelength thulium fiber laser. , 2008, Journal of endourology.

[11]  Richard A. Lasher,et al.  Intracellular calcium transients evoked by pulsed infrared radiation in neonatal cardiomyocytes , 2011, The Journal of physiology.

[12]  Austin R. Duke,et al.  Spatial and temporal variability in response to hybrid electro-optical stimulation , 2012, Journal of neural engineering.

[13]  Paul R. Stoddart,et al.  Modeling of light absorption in tissue during infrared neural stimulation. , 2012, Journal of biomedical optics.

[14]  Joseph T. Walsh,et al.  Laser stimulation of auditory neurons at high repetition rate , 2007, SPIE BiOS.

[15]  J. Boulnois,et al.  Photophysical processes in recent medical laser developments: A review , 2005, Lasers in Medical Science.

[16]  A. Wood,et al.  Application of a temperature‐dependent fluorescent dye (Rhodamine B) to the measurement of radiofrequency radiation‐induced temperature changes in biological samples , 2009, Bioelectromagnetics.

[17]  H. H. Pennes.  Analysis of tissue and arterial blood temperatures in the resting human forearm. 1948. , 1948, Journal of applied physiology.

[18]  H. H. Pennes.  Analysis of tissue and arterial blood temperatures in the resting human forearm. , 1948, Journal of applied physiology.

[19]  John D. Owens,et al.  GPU Computing , 2008, Proceedings of the IEEE.

[20]  F. J. Duarte,et al.  Heat diffusion in a solid sphere and Fourier theory: An elementary practical example , 1979 .

[21]  E. Watanabe,et al.  Assessment of heating effects in skin during continuous wave near infrared spectroscopy. , 2000, Journal of biomedical optics.

[22]  J. C. Jaeger,et al.  Conduction of Heat in Solids , 1952 .

[23]  Mikhail G. Shapiro,et al.  Infrared light excites cells by changing their electrical capacitance , 2012, Nature Communications.

[24]  Claus-Peter Richter,et al.  Laser stimulation of auditory neurons: effect of shorter pulse duration and penetration depth. , 2008, Biophysical journal.

[25]  Stefan Turek,et al.  GPU acceleration of an unmodified parallel finite element Navier-Stokes solver , 2009, 2009 International Conference on High Performance Computing & Simulation.

[26]  J. Curcio,et al.  Near infrared absorption spectrum of liquid water , 1951 .

[27]  Daniel Weinreich,et al.  Excitation of primary afferent neurons by near-infrared light in vitro , 2010, Neuroreport.

[28]  Bo Chen,et al.  Modeling thermal damage in skin from 2000-nm laser irradiation. , 2006, Journal of biomedical optics.

[29]  Sharon Thomsen,et al.  Optically mediated nerve stimulation: Identification of injury thresholds , 2007, Lasers in surgery and medicine.

[30]  J. Langerholc,et al.  Thermodynamic analysis of laser irradiation of biological tissue. , 1978, Applied optics.

[31]  Christopher J. Fluke,et al.  Teraflop per second gravitational lensing ray-shooting using graphics processing units , 2009, 0905.2453.

[32]  Claus-Peter Richter,et al.  Infrared neural stimulation: Beam path in the guinea pig cochlea , 2011, Hearing Research.