Gastric enterochromaffin-like (ECL) cells in hypergastrinaemic duodenal ulcer disease.

Patients with hypergastrinaemic duodenal ulcer disease were studied to determine whether chronic moderate hypergastrinaemia produces hyperplasia of gastric enterochromaffin-like cells in man. Eight patients had peak postprandial plasma gastrin concentrations greater than 200 pmol/l, which is the 92nd percentile for patients with duodenal ulcer disease in this laboratory. The control group was eight patients with duodenal ulcers whose peak postprandial gastrin concentrations were less than 200 pmol/l. Basal and peak postprandial plasma gastrin concentrations were 107 (37) and 306 (66) pmol/l (mean (SEM] respectively in the hypergastrinaemic patients compared with 26 (4) and 137 (14) pmol/l respectively in the controls. There was no significant difference in the density of gastrin enterochromaffin-like cells between the two groups. The number of enterochromaffin-like cells per high power field was 53 (8) in the hypergastrinaemic patients compared with 50 (8) in the controls. We conclude that chronic moderate hypergastrinaemia does not produce hyperplasia of enterochromaffin-like cells in man. Our hypergastrinaemic group had plasma gastrin concentrations similar to, or greater than those reported during treatment with drugs such as omeprazole and histamine H2 receptor blockers.

[1]  W. Creutzfeldt,et al.  Long-term omeprazole treatment in man: effects on gastric endocrine cell populations. , 1988, Digestion.

[2]  F. Sundler,et al.  Achlorhydria: hypergastrinaemia: carcinoids--a flawed hypothesis. , 1987, Gut.

[3]  Richardson At,et al.  Gastric carcinoid tumours associated with hypergastrinaemia and pernicious anaemia--regression of tumors by antrectomy. A case report. , 1987 .

[4]  P. Ruszniewski,et al.  Development of gastric argyrophil carcinoid tumors in a case of zollinger‐ellison syndrome with primary hyperparathyroidism during long‐term antisecretory treatment , 1987, Cancer.

[5]  G. Bodemar,et al.  The effect of 20 Mg omeprazole daily on serum gastrin, 24-h intragastric acidity, and bile acid concentration in duodenal ulcer patients. , 1987, Scandinavian journal of gastroenterology.

[6]  A. Richards,et al.  Gastric carcinoid tumours associated with hypergastrinaemia and pernicious anaemia--regression of tumors by antrectomy. A case report. , 1987, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

[7]  H. Renvall,et al.  Relations between circulating gastrin and endocrine cell proliferation in the atrophic gastric fundic mucosa. , 1986, Scandinavian journal of gastroenterology.

[8]  F. Sundler,et al.  Plasma gastrin and gastric enterochromaffinlike cell activation and proliferation. Studies with omeprazole and ranitidine in intact and antrectomized rats. , 1986, Gastroenterology.

[9]  L. Bardram,et al.  Gastric endocrine cells in omeprazole-treated and untreated patients with the Zollinger-Ellison syndrome. , 1986, Digestion.

[10]  W. Creutzfeldt,et al.  Effect of short- and long-term feeding of omeprazole on rat gastric endocrine cells. , 1986, Digestion.

[11]  P. Facer,et al.  Chromogranin: a newly recognized marker for endocrine cells of the human gastrointestinal tract. , 1985, Gastroenterology.

[12]  N. W. Spurling,et al.  Association of long lasting unsurmountable histamine H2 blockade and gastric carcinoid tumours in the rat. , 1985, Gut.

[13]  H. Renvall,et al.  Gastric endocrine cell hyperplasia and carcinoid tumors in pernicious anemia. , 1985, Gastroenterology.

[14]  L Ekman,et al.  Toxicological studies on omeprazole. , 1985, Scandinavian journal of gastroenterology. Supplement.

[15]  G. Pals,et al.  Effect of oral omeprazole on serum gastrin and serum pepsinogen I levels. , 1984, Gastroenterology.

[16]  T. Tomita,et al.  Further experience with Pseudo-Zollinger-Ellison syndrome: Its Place in the management of neuroendocrine duodenal ulceration , 1984, World journal of surgery.

[17]  V. Go,et al.  The syndrome of gastric argyrophil carcinoid tumors and nonantral gastric atrophy. , 1983, Annals of internal medicine.

[18]  R. Lloyd,et al.  Specific endocrine tissue marker defined by a monoclonal antibody. , 1983, Science.

[19]  J. Valenzuela,et al.  Cholecystokinin-octapeptidelike immunoreactivity in human plasma. , 1982, Gastroenterology.

[20]  J. Rotter,et al.  Family studies of hypergastrinemic, hyperpepsinogenemic I duodenal ulcer. , 1981, Annals of internal medicine.

[21]  P. Isaacson,et al.  Diffuse enterochromaffin-like (ECL) cell hyperplasia and multiple gastric carcinoids: a complication of pernicious anaemia. , 1981, Gut.

[22]  C. Bordi,et al.  Gastric endocrine cell proliferation. Association with Zollinger-Ellison syndrome. , 1974, Archives of pathology.

[23]  S. Berson,et al.  Radioimmunoassay of gastrin. , 1970, Gastroenterology.

[24]  T. Sharpton,et al.  "Gut". , 2022, Canadian Medical Association journal.