Role of vitamin D in targeting cancer and cancer stem cell populations and its therapeutic implications

[1]  Junfang Ji,et al.  Panoramic view of microRNAs in regulating cancer stem cells. , 2022, Essays in biochemistry.

[2]  H. Wildiers,et al.  The Combination of the CDK4/6 Inhibitor, Palbociclib, With the Vitamin D3 Analog, Inecalcitol, Has Potent In Vitro and In Vivo Anticancer Effects in Hormone-Sensitive Breast Cancer, But Has a More Limited Effect in Triple-Negative Breast Cancer , 2022, Frontiers in Endocrinology.

[3]  E. Turlej,et al.  Micro-RNAs in Response to Active Forms of Vitamin D3 in Human Leukemia and Lymphoma Cells , 2022, International journal of molecular sciences.

[4]  Gang Yin,et al.  Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities , 2022, Signal Transduction and Targeted Therapy.

[5]  Yaoting Gui,et al.  Mutations of MSH5 in nonobstructive azoospermia (NOA) and rescued via in vivo gene editing , 2022, Signal Transduction and Targeted Therapy.

[6]  H. Wildiers,et al.  The role of vitamin D in breast cancer risk and progression. , 2021, Endocrine-related cancer.

[7]  Yun-Gen Xu,et al.  FDI-6 inhibits the expression and function of FOXM1 to sensitize BRCA-proficient triple-negative breast cancer cells to Olaparib by regulating cell cycle progression and DNA damage repair , 2021, Cell Death & Disease.

[8]  P. Bergman,et al.  ‘Palliative-D’—Vitamin D Supplementation to Palliative Cancer Patients: A Double Blind, Randomized Placebo-Controlled Multicenter Trial , 2021, Cancers.

[9]  Zengliang Wang,et al.  [Nutrient Status of Vitamin D among Cancer Patients]. , 2021, Zhongguo fei ai za zhi = Chinese journal of lung cancer.

[10]  Y. Bustanji,et al.  Evaluation of the potential anticancer activity of different vitamin D metabolites on colorectal and breast cancer cell lines , 2021, Hormone Molecular Biology and Clinical Investigation.

[11]  R. Punchoo,et al.  Policing Cancer: Vitamin D Arrests the Cell Cycle , 2020, International journal of molecular sciences.

[12]  G. Colombo,et al.  Prostaglandin E2 and Cancer: Insight into Tumor Progression and Immunity , 2020, Biology.

[13]  J. Manson,et al.  Effect of Vitamin D3 Supplements on Development of Advanced Cancer , 2020, JAMA network open.

[14]  D. Xie,et al.  VDR–SOX2 signaling promotes colorectal cancer stemness and malignancy in an acidic microenvironment , 2020, Signal Transduction and Targeted Therapy.

[15]  John H. White,et al.  Vitamin D and Immune Regulation: Antibacterial, Antiviral, Anti‐Inflammatory , 2020, JBMR plus.

[16]  R. Patalano,et al.  Vitamin D-Induced Molecular Mechanisms to Potentiate Cancer Therapy and to Reverse Drug-Resistance in Cancer Cells , 2020, Nutrients.

[17]  C. Carlberg,et al.  An update on vitamin D signaling and cancer. , 2020, Seminars in cancer biology.

[18]  C. Carlberg,et al.  Key Vitamin D Target Genes with Functions in the Immune System , 2020, Nutrients.

[19]  D. Augeri,et al.  Vitamin D Compounds and Cancer Stem Cells in Cancer Prevention , 2020 .

[20]  Dawei Xu,et al.  Polyphyllin I induces cell cycle arrest in prostate cancer cells via the upregulation of IL6 and P21 expression , 2019, Medicine.

[21]  J. Mayerle,et al.  Antifibrotic effects of hypocalcemic vitamin D analogs in murine and human hepatic stellate cells and in the CCl4 mouse model , 2019, Laboratory Investigation.

[22]  Yu Zhang,et al.  Association between vitamin D supplementation and mortality: systematic review and meta-analysis , 2019, BMJ.

[23]  Lizhi Liu,et al.  1α,25‑Dihydroxyvitamin D3 restrains stem cell‑like properties of ovarian cancer cells by enhancing vitamin D receptor and suppressing CD44. , 2019, Oncology reports.

[24]  J. Manson,et al.  Vitamin D supplementation and total cancer incidence and mortality: a meta-analysis of randomized controlled trials. , 2019, Annals of oncology : official journal of the European Society for Medical Oncology.

[25]  Weilin Wang,et al.  Therapeutic potential of targeting the Wnt/β-catenin signaling pathway in colorectal cancer. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[26]  J. Manson,et al.  Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease , 2019, The New England journal of medicine.

[27]  M. Najafi,et al.  Cyclooxygenase‐2 in cancer: A review , 2018, Journal of cellular physiology.

[28]  C. Cho,et al.  Repurposing vitamin D for treatment of human malignancies via targeting tumor microenvironment , 2018, Acta pharmaceutica Sinica. B.

[29]  W. Liu,et al.  The Anti-Inflammatory Effects of Vitamin D in Tumorigenesis , 2018, International journal of molecular sciences.

[30]  M. A. Cuadrado-Cenzual,et al.  Vitamin D: And its role in breast cancer , 2018, The Kaohsiung journal of medical sciences.

[31]  D. Miao,et al.  1,25‐Dihydroxy vitamin D prevents tumorigenesis by inhibiting oxidative stress and inducing tumor cellular senescence in mice , 2018, International journal of cancer.

[32]  R. Korn,et al.  A SU2C catalyst randomized phase II trial of pembrolizumab with or without paricalcitol in patients with stage IV pancreatic cancer who have been placed in best possible response. , 2018 .

[33]  Sang-Min Jeon,et al.  Exploring vitamin D metabolism and function in cancer , 2018, Experimental & Molecular Medicine.

[34]  Amit Kumar Srivastava,et al.  Depleting ovarian cancer stem cells with calcitriol , 2018, Oncotarget.

[35]  M. Ghanei,et al.  Promising role for Gc-MAF in cancer immunotherapy: from bench to bedside , 2017, Caspian journal of internal medicine.

[36]  W. Xue,et al.  Effect of 1,25-(OH)2D3 on Proliferation of Fibroblast-Like Synoviocytes and Expressions of Pro-Inflammatory Cytokines through Regulating MicroRNA-22 in a Rat Model of Rheumatoid Arthritis , 2017, Cellular Physiology and Biochemistry.

[37]  S. Gowder A Critical Evaluation of Vitamin D - Basic Overview , 2017 .

[38]  F. Uberti,et al.  Vitamin D in Oxidative Stress and Diseases , 2017 .

[39]  C. Cooper,et al.  Vitamin D supplementation in the prevention and management of major chronic diseases not related to mineral homeostasis in adults: research for evidence and a scientific statement from the European society for clinical and economic aspects of osteoporosis and osteoarthritis (ESCEO) , 2017, Endocrine.

[40]  J. Klawitter,et al.  Vitamin D receptor regulates autophagy in the normal mammary gland and in luminal breast cancer cells , 2017, Proceedings of the National Academy of Sciences.

[41]  N. Zarghami,et al.  Silibinin-loaded magnetic nanoparticles inhibit hTERT gene expression and proliferation of lung cancer cells , 2017, Artificial cells, nanomedicine, and biotechnology.

[42]  Hong-ce Chen,et al.  Targeting cancer stem cells in cancer therapy , 2016 .

[43]  ping wang,et al.  1α,25(OH)2D3 Suppresses the Migration of Ovarian Cancer SKOV-3 Cells through the Inhibition of Epithelial–Mesenchymal Transition , 2016, International journal of molecular sciences.

[44]  H. Adomat,et al.  Calcitriol and 20(S)-protopanaxadiol synergistically inhibit growth and induce apoptosis in human prostate cancer cells , 2016, The Journal of Steroid Biochemistry and Molecular Biology.

[45]  J. Manson,et al.  Vitamin D and colorectal cancer: molecular, epidemiological and clinical evidence , 2016, British Journal of Nutrition.

[46]  P. Dhawan,et al.  Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects. , 2016, Physiological reviews.

[47]  Y. Fall,et al.  The alkynylphosphonate analogue of calcitriol EM1 has potent anti-metastatic effects in breast cancer , 2015, The Journal of Steroid Biochemistry and Molecular Biology.

[48]  X. Guan,et al.  Cancer metastases: challenges and opportunities , 2015, Acta pharmaceutica Sinica. B.

[49]  R. Evans,et al.  Calcipotriol Targets LRP6 to Inhibit Wnt Signaling in Pancreatic Cancer , 2015, Molecular Cancer Research.

[50]  N. Suh,et al.  Targeting cancer stem cells in solid tumors by vitamin D , 2015, The Journal of Steroid Biochemistry and Molecular Biology.

[51]  S. Glück,et al.  Improved clinical outcomes associated with vitamin D supplementation during adjuvant chemotherapy in patients with HER2+ nonmetastatic breast cancer. , 2015, Clinical breast cancer.

[52]  J. Meyerhardt,et al.  Vitamin D status and survival of metastatic colorectal cancer patients: Results from CALGB/SWOG 80405 (Alliance). , 2015 .

[53]  D. Gewirtz,et al.  A novel cytostatic form of autophagy in sensitization of non-small cell lung cancer cells to radiation by vitamin D and the vitamin D analog, EB 1089 , 2014, Autophagy.

[54]  L. Mishra,et al.  Activation of Vitamin D Receptor Signaling Downregulates the Expression of Nuclear FOXM1 Protein and Suppresses Pancreatic Cancer Cell Stemness , 2014, Clinical Cancer Research.

[55]  E. Raymond,et al.  Phase I Safety and Pharmacodynamic of Inecalcitol, a Novel VDR Agonist with Docetaxel in Metastatic Castration-Resistant Prostate Cancer Patients , 2014, Clinical Cancer Research.

[56]  E. Giovannucci,et al.  The role of vitamin D in reducing cancer risk and progression , 2014, Nature Reviews Cancer.

[57]  H. Maehr,et al.  Inhibition of the Transition of Ductal Carcinoma In Situ to Invasive Ductal Carcinoma by a Gemini Vitamin D Analog , 2014, Cancer Prevention Research.

[58]  M. Gulisano,et al.  GC protein-derived macrophage-activating factor decreases α-N-acetylgalactosaminidase levels in advanced cancer patients , 2013, Oncoimmunology.

[59]  G. Pirianov,et al.  Role of Insulin-Like Growth Factor Binding Protein-3 in 1, 25-Dihydroxyvitamin-D3-Induced Breast Cancer Cell Apoptosis , 2013, International journal of cell biology.

[60]  S. Akman,et al.  Oral paricalcitol (19-nor-1,25-dihydroxyvitamin D2) in women receiving chemotherapy for metastatic breast cancer , 2013, Cancer biology & therapy.

[61]  Wei-dong Yu,et al.  Inecalcitol, an analog of 1,25D₃, displays enhanced antitumor activity through the induction of apoptosis in a squamous cell carcinoma model system , 2013, Cell cycle.

[62]  M. Jäättelä,et al.  IFNB1/interferon-β-induced autophagy in MCF-7 breast cancer cells counteracts its proapoptotic function , 2013, Autophagy.

[63]  H. Maehr,et al.  Targeting CD44-STAT3 Signaling by Gemini Vitamin D Analog Leads to Inhibition of Invasion in Basal-Like Breast Cancer , 2013, PloS one.

[64]  H. Juang,et al.  MART-10, a New Generation of Vitamin D Analog, Is More Potent than 1α,25-Dihydroxyvitamin D3 in Inhibiting Cell Proliferation and Inducing Apoptosis in ER+ MCF-7 Breast Cancer Cells , 2012, Evidence-based complementary and alternative medicine : eCAM.

[65]  R. Okamoto,et al.  Inecalcitol, an analog of 1α,25(OH)2D3, induces growth arrest of androgen‐dependent prostate cancer cells , 2012, International journal of cancer.

[66]  J. Fleet,et al.  Vitamin D and cancer: a review of molecular mechanisms. , 2012, Biochemical Journal.

[67]  M. Gulisano,et al.  Effects of vitamin D-binding protein-derived macrophage-activating factor on human breast cancer cells. , 2012, Anticancer research.

[68]  Yanlei Ma,et al.  Association between vitamin D and risk of colorectal cancer: a systematic review of prospective studies. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[69]  Y. Fall,et al.  Novel alkynylphosphonate analogue of calcitriol with potent antiproliferative effects in cancer cells and lack of calcemic activity. , 2011, ACS medicinal chemistry letters.

[70]  C. Heldin,et al.  A decisive function of transforming growth factor-β/Smad signaling in tissue morphogenesis and differentiation of human HaCaT keratinocytes , 2011, Molecular biology of the cell.

[71]  Fang Liu,et al.  A Novel Gemini Vitamin D Analog Represses the Expression of a Stem Cell Marker CD44 in Breast Cancer , 2011, Molecular Pharmacology.

[72]  S. Cramer,et al.  The Tissue-Specific Stem Cell as a Target for Chemoprevention , 2011, Stem Cell Reviews and Reports.

[73]  S. Dridi,et al.  Vitamin D Binding Protein-Macrophage Activating Factor Directly Inhibits Proliferation, Migration, and uPAR Expression of Prostate Cancer Cells , 2010, PloS one.

[74]  F. Campbell,et al.  Apc(MIN) modulation of vitamin D secosteroid growth control. , 2010, Carcinogenesis.

[75]  E. Jacobs,et al.  Vitamin D receptor ligands, adenomatous polyposis coli, and the vitamin D receptor FokI polymorphism collectively modulate β‐catenin activity in colon cancer cells , 2010, Molecular carcinogenesis.

[76]  M. McCullough,et al.  Effects of Supplemental Vitamin D and Calcium on Oxidative DNA Damage Marker in Normal Colorectal Mucosa: A Randomized Clinical Trial , 2010, Cancer Epidemiology, Biomarkers & Prevention.

[77]  Zhentao Zhang,et al.  1,25 dihydroxyvitamin D-mediated orchestration of anticancer, transcript-level effects in the immortalized, non-transformed prostate epithelial cell line, RWPE1 , 2010, BMC Genomics.

[78]  D. Morris,et al.  Inhibition of hepatocellular cancer by EB1089: in vitro and in vive study. , 2008, Anticancer research.

[79]  S. Nicosia,et al.  Vitamin D receptor is a novel drug target for ovarian cancer treatment. , 2006, Current cancer drug targets.

[80]  J. Welsh,et al.  The Molecular Basis of Vitamin D Receptor and β-Catenin Crossregulation , 2006 .

[81]  J. Welsh,et al.  The molecular basis of vitamin D receptor and beta-catenin crossregulation. , 2006, Molecular cell.

[82]  J. Lovato,et al.  Phase I/II Study of 19-nor-1α-25-Dihydroxyvitamin D2 (Paricalcitol) in Advanced, Androgen-Insensitive Prostate Cancer , 2005, Clinical Cancer Research.

[83]  S. Nicosia,et al.  Suppression of Death Receptor-mediated Apoptosis by 1,25-Dihydroxyvitamin D3 Revealed by Microarray Analysis* , 2005, Journal of Biological Chemistry.

[84]  D. Feldman,et al.  Molecular mechanisms mediating the anti-proliferative effects of Vitamin D in prostate cancer , 2005, The Journal of Steroid Biochemistry and Molecular Biology.

[85]  David Feldman,et al.  Regulation of prostaglandin metabolism by calcitriol attenuates growth stimulation in prostate cancer cells. , 2005, Cancer research.

[86]  D. Moras,et al.  Superagonistic Action of 14-epi-Analogs of 1,25-Dihydroxyvitamin D Explained by Vitamin D Receptor-Coactivator Interaction , 2005, Molecular Pharmacology.

[87]  S. Nicosia,et al.  Growth suppression of ovarian cancer xenografts in nude mice by vitamin D analogue EB1089. , 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.

[88]  J. Brooks,et al.  Analysis of vitamin D‐regulated gene expression in LNCaP human prostate cancer cells using cDNA microarrays , 2004, The Prostate.

[89]  N. Raghavachari,et al.  Vitamin D Growth Inhibition of Breast Cancer Cells: Gene Expression Patterns Assessed by cDNA Microarray , 2003, Breast Cancer Research and Treatment.

[90]  J. Dancey,et al.  A phase II study of the vitamin D analogue Seocalcitol in patients with inoperable hepatocellular carcinoma , 2003, British Journal of Cancer.

[91]  P Jack Hoopes,et al.  The combination of a potent vitamin D3 analog, EB 1089, with ionizing radiation reduces tumor growth and induces apoptosis of MCF-7 breast tumor xenografts in nude mice. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[92]  S. Kato,et al.  Characterization of a vitamin D receptor knockout mouse as a model of colorectal hyperproliferation and DNA damage. , 2001, Carcinogenesis.

[93]  John H. White,et al.  Action of low calcemic 1alpha,25-dihydroxyvitamin D3 analogue EB1089 in head and neck squamous cell carcinoma. , 2001, Journal of the National Cancer Institute.

[94]  T. McDonnell,et al.  Calcitriol-Induced Apoptosis in LNCaP Cells Is Blocked By Overexpression of Bcl-21. , 2000, Endocrinology.

[95]  T. McDonnell,et al.  Printed in U.S.A. Copyright © 2000 by The Endocrine Society Calcitriol-Induced Apoptosis in LNCaP Cells Is Blocked By Overexpression of Bcl-2* , 1999 .

[96]  P. Quesenberry,et al.  Expression of multiple angiogenic cytokines in cultured normal human prostate epithelial cells: Predominance of vascular endothelial growth factor , 1999, International journal of cancer.

[97]  T. Craig,et al.  Identification of 1α,25-Dihydroxyvitamin D3 Response Elements in the Human Transforming Growth Factor β2 Gene† , 1999 .

[98]  T. Craig,et al.  Identification of 1 alpha,25-dihydroxyvitamin D3 response elements in the human transforming growth factor beta 2 gene. , 1999, Biochemistry.

[99]  R. Coombes,et al.  A phase I study of the vitamin D analogue EB 1089 in patients with advanced breast and colorectal cancer. , 1998, British Journal of Cancer.