Micro-Operations on Cells in Tissue Cultures

The application of the micromanipulative technique to the study of cells in tissue culture has for a long time offered an interesting, though difficult, field of research. Thus far, comparatively little has been done, the most notable contributions being those of Levi and of Peterfi and co-workers (Levi, 1926 ; Peterfi and Olivo, 1925 ; Peterfi, 1927 ; Peterfi and Kapel, 1928). Peterfi has also written a special paper on the technique (1927). The main deterrent in this work has been the lack of sufficient ease in the accurate and continuous control of the microneedles under the conditions required.