Zidampidine, an aryl phosphate derivative of AZT: in vivo pharmacokinetics, metabolism, toxicity, and anti-viral efficacy against hemorrhagic fever caused by Lassa virus.

[1]  T. Hawn,et al.  Emerging Infectious Diseases , 2011, Berkowitz’s Pediatrics: A Primary Care Approach.

[2]  S. Günther,et al.  Imported Lassa fever in Germany: surveillance and management of contact persons. , 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[3]  A. Hoerauf,et al.  Monitoring of clinical and laboratory data in two cases of imported Lassa fever. , 2002, Microbes and infection.

[4]  C. Mcguigan,et al.  Synthesis and antiviral activity of acyclovir-5'-(phenyl methoxy alaninyl) phosphate as a possible membrane-soluble nucleotide prodrug. , 2000, Bioorganic & medicinal chemistry letters.

[5]  F. Uckun,et al.  Importance of the Alanine Methyl Ester Side Chain for the Biological Activity Profile of Dual-Function Phenyl Phosphate Derivatives of Bromo-Methoxy-Zidovudine , 2000, Antiviral Chemistry & Chemotherapy.

[6]  F. Uckun,et al.  Structural Requirements for Potent Human Spermicidal Activity of Dual-Function Aryl Phosphate Derivative of Bromo-Methoxy Zidovudine (Compound WHI-07)1 , 2000, Biology of reproduction.

[7]  F. Uckun,et al.  Evaluation of subchronic (13 weeks) and reproductive toxicity potential of intravaginal gel-microemulsion formulation of a dual-function phenyl phosphate derivative of bromo-methoxy zidovudine (compound WHI-05) in B(6)C(3)F(1) mice. , 2000, Contraception.

[8]  F. Uckun,et al.  WHI-05, a novel bromo-methoxy substituted phenyl phosphate derivative of zidovudine, is a dual-action spermicide with potent anti-HIV activity. , 1999, Contraception.

[9]  F. Uckun,et al.  Synthesis, characterization and preclinical formulation of a dual-action phenyl phosphate derivative of bromo-methoxy zidovudine (compound WHI-07) with potent anti-HIV and spermicidal activities. , 1999, Molecular human reproduction.

[10]  F. Uckun,et al.  AZT-5′-(p-Bromophenyl Methoxyalaninyl Phosphate) as a Potent and Non-Toxic Anti-Human Immunodeficiency Virus Agent , 1999, Antiviral chemistry & chemotherapy.

[11]  E. De Clercq,et al.  Aryl phosphoramidate derivatives of d4T have improved anti-HIV efficacy in tissue culture and may act by the generation of a novel intracellular metabolite. , 1996, Journal of medicinal chemistry.

[12]  A. Hay,et al.  Synthesis and anti-HIV activity of some novel diaryl phosphate derivatives of AZT. , 1994, Antiviral research.

[13]  E. De Clercq,et al.  Intracellular delivery of bioactive AZT nucleotides by aryl phosphate derivatives of AZT. , 1993, Journal of medicinal chemistry.

[14]  James H. Wikel,et al.  The use of neural networks for variable selection in QSAR , 1993 .

[15]  A. Hay,et al.  Aryl phosphate derivatives of AZT retain activity against HIV1 in cell lines which are resistant to the action of AZT. , 1992, Antiviral research.

[16]  C. Mcguigan,et al.  Synthesis and anti-HIV activity of some haloalkyl phosphoramidate derivatives of 3'-azido-3'-deoxythymidine (AZT): potent activity of the trichloroethyl methoxyalaninyl compound. , 1991, Antiviral research.

[17]  D. Jeffries,et al.  Synthesis and anti-HIV evaluation of some phosphoramidate derivatives of AZT: studies on the effect of chain elongation on biological activity. , 1990, Antiviral research.

[18]  L. Brammer,et al.  Lassa fever in the United States. Investigation of a case and new guidelines for management. , 1990, The New England journal of medicine.

[19]  D. Jeffries,et al.  Synthesis and Evaluation of Some Novel Phosphoramidate Derivatives of 3′-Azido-3′-Deoxythymidine (AZT) as Anti-HIV Compounds , 1990 .

[20]  C. Mcguigan,et al.  Novel phosphate derivatives of zidovudine as anti-HIV compounds. , 1990, AIDS.

[21]  E. De Clercq,et al.  Differential patterns of intracellular metabolism of 2',3'-didehydro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine, two potent anti-human immunodeficiency virus compounds. , 1989, The Journal of biological chemistry.

[22]  R. Pauwels,et al.  Anti-retrovirus activity of 3'-fluoro- and 3'-azido-substituted pyrimidine 2',3'-dideoxynucleoside analogues. , 1988, Biochemical pharmacology.

[23]  E. Sikuler,et al.  [Lassa fever--first case diagnosed in Israel]. , 1988, Harefuah.

[24]  E. S. Smith,et al.  A prospective study of the epidemiology and ecology of Lassa fever. , 1987, The Journal of infectious diseases.

[25]  P. Jahrling,et al.  Pediatric Lassa fever: a review of 33 Liberian cases. , 1987, The American journal of tropical medicine and hygiene.

[26]  J. McCormick,et al.  Lassa virus hepatitis: a study of fatal Lassa fever in humans. , 1986, The American journal of tropical medicine and hygiene.

[27]  J. McCormick,et al.  Lassa fever in children in Sierra Leone, West Africa. , 1986, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[28]  P. Jahrling,et al.  Endemic Lassa fever in Liberia. I. Clinical and epidemiological aspects at Curran Lutheran Hospital, Zorzor, Liberia. , 1984, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[29]  T. Monath.  Lassa fever: review of epidemiology and epizootiology. , 1975, Bulletin of the World Health Organization.

[30]  J. Frame.  Surveillance of Lassa fever in missionaries stationed in West Africa. , 1975, Bulletin of the World Health Organization.

[31]  J. Frame,et al.  Lassa fever, a new virus disease of man from West Africa. I. Clinical description and pathological findings. , 1970, The American journal of tropical medicine and hygiene.

[32]  J. Casals,et al.  Lassa fever, a new virus disease of man from West Africa. 3. Isolation and characterization of the virus. , 1970, The American journal of tropical medicine and hygiene.