Viral-host interactions that control HIV-1 transcriptional elongation.

本综述论文针对艾滋病病毒HIV转录研究的最新进展，对各种P-TEFb复合体的结构、功能、及其与艾滋病病毒HIV编码的Tat蛋白的相互作用、Tat的翻译后修饰、以及艾滋病病毒HIV的转录调控机制进行了综述，提高了对艾滋病病毒转录延伸机制的理解，创新性地提出了对抗艾滋病病毒感染及潜伏的新策略，在理论研究及应用方面意义重大。

[1]  J. Karn,et al.  Phosphorylation of CDK9 at Ser175 Enhances HIV Transcription and Is a Marker of Activated P-TEFb in CD4+ T Lymphocytes , 2013, PLoS pathogens.

[2]  T. Kiss,et al.  RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP , 2013, Nucleic acids research.

[3]  N. Krogan,et al.  The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat , 2013, eLife.

[4]  N. Krogan,et al.  HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold , 2012, Proceedings of the National Academy of Sciences.

[5]  P. Sebastiani,et al.  BET bromodomain inhibition as a novel strategy for reactivation of HIV‐1 , 2012, Journal of leukocyte biology.

[6]  Gaurav D. Gaiha,et al.  Reactivation of latent HIV-1 by inhibition of BRD4. , 2012, Cell reports.

[7]  Qiang Zhou,et al.  The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation , 2012, Nucleic acids research.

[8]  John T. Lis,et al.  Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans , 2012, Nature Reviews Genetics.

[9]  B. Peterlin,et al.  Bromodomain and Extra-terminal (BET) Bromodomain Inhibition Activate Transcription via Transient Release of Positive Transcription Elongation Factor b (P-TEFb) from 7SK Small Nuclear Ribonucleoprotein* , 2012, The Journal of Biological Chemistry.

[10]  A. Rice,et al.  MicroRNA-Mediated Restriction of HIV-1 in Resting CD4+ T Cells and Monocytes , 2012, Viruses.

[11]  B. Peterlin,et al.  PKC phosphorylates HEXIM1 and regulates P-TEFb activity , 2012, Nucleic acids research.

[12]  A. Rice,et al.  Phosphatase PPM1A negatively regulates P-TEFb function in resting CD4+ T cells and inhibits HIV-1 gene expression , 2012, Retrovirology.

[13]  Caleb K. Chan,et al.  The ubiquitin ligase Siah1 controls ELL2 stability and formation of super elongation complexes to modulate gene transcription. , 2012, Molecular cell.

[14]  Qiang Zhou,et al.  RNA polymerase II elongation control. , 2012, Annual review of biochemistry.

[15]  F. Rayne,et al.  The Ins and Outs of HIV‐1 Tat , 2012, Traffic.

[16]  M. Wainberg,et al.  The Viral Protein Tat Can Inhibit the Establishment of HIV-1 Latency , 2012, Journal of Virology.

[17]  Qiang Zhou,et al.  The control of HIV transcription: keeping RNA polymerase II on track. , 2011, Cell host & microbe.

[18]  T. Mahmoudi,et al.  Repressive LTR Nucleosome Positioning by the BAF Complex Is Required for HIV Latency , 2011, PLoS biology.

[19]  S. Lowe,et al.  RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia , 2011, Nature.

[20]  P. Sandy,et al.  Targeting MYC dependence in cancer by inhibiting BET bromodomains , 2011, Proceedings of the National Academy of Sciences.

[21]  C. Allis,et al.  Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes , 2011, Proceedings of the National Academy of Sciences.

[22]  R. Young,et al.  BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc , 2011, Cell.

[23]  W. Greene,et al.  Activation of HIV Transcription by the Viral Tat Protein Requires a Demethylation Step Mediated by Lysine-specific Demethylase 1 (LSD1/KDM1) , 2011, PLoS pathogens.

[24]  Jonathan Karn,et al.  T-cell receptor signaling enhances transcriptional elongation from latent HIV proviruses by activating P-TEFb through an ERK-dependent pathway. , 2011, Journal of molecular biology.

[25]  J. Karn,et al.  Epigenetic Silencing of HIV-1 by the Histone H3 Lysine 27 Methyltransferase Enhancer of Zeste 2 , 2011, Journal of Virology.

[26]  M. Levine.  Paused RNA Polymerase II as a Developmental Checkpoint , 2011, Cell.

[27]  Jennifer A. Smith,et al.  The Brd4 Extraterminal Domain Confers Transcription Activation Independent of pTEFb by Recruiting Multiple Proteins, Including NSD3 , 2011, Molecular and Cellular Biology.

[28]  Qiang Zhou,et al.  New Insights into the Control of HIV-1 Transcription: When Tat Meets the 7SK snRNP and Super Elongation Complex (SEC) , 2011, Journal of Neuroimmune Pharmacology.

[29]  Wei Yang,et al.  Regulation of Tat Acetylation and Transactivation Activity by the Microtubule-associated Deacetylase HDAC6* , 2011, The Journal of Biological Chemistry.

[30]  J. Karn.  The molecular biology of HIV latency: breaking and restoring the Tat-dependent transcriptional circuit , 2011, Current opinion in HIV and AIDS.

[31]  Min Liu,et al.  Tat acetylation regulates its actions on microtubule dynamics and apoptosis in T lymphocytes , 2011, The Journal of pathology.

[32]  Tatiana Ammosova,et al.  Expression of a Protein Phosphatase 1 Inhibitor, cdNIPP1, Increases CDK9 Threonine 186 Phosphorylation and Inhibits HIV-1 Transcription* , 2010, The Journal of Biological Chemistry.

[33]  T. Kiss,et al.  Controlling Cellular P-TEFb Activity by the HIV-1 Transcriptional Transactivator Tat , 2010, PLoS pathogens.

[34]  K. Kehn-Hall,et al.  Transcription through the HIV-1 nucleosomes: effects of the PBAF complex in Tat activated transcription. , 2010, Virology.

[35]  D. Price,et al.  The Mechanism of Release of P-TEFb and HEXIM1 from the 7SK snRNP by Viral and Cellular Activators Includes a Conformational Change in 7SK , 2010, PloS one.

[36]  Tina Lenasi,et al.  Kick-sTARting HIV-1 transcription elongation by 7SK snRNP deporTATion , 2010, Nature Structural &Molecular Biology.

[37]  Alan D. Frankel,et al.  RNA-mediated displacement of an inhibitory snRNP complex activates transcription elongation , 2010, Nature Structural &Molecular Biology.

[38]  A. Burlingame,et al.  HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription. , 2010, Molecular cell.

[39]  Yves Levy,et al.  HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP. , 2010, Molecular cell.

[40]  T. Tahirov,et al.  Crystal structure of HIV-1 Tat complexed with human P-TEFb , 2010, Nature.

[41]  R. Maraia,et al.  Conserved and divergent features of the structure and function of La and La-related proteins (LARPs). , 2010, Biochimica et biophysica acta.

[42]  J. Karn,et al.  Establishment of HIV Latency in Primary CD4+ Cells Is due to Epigenetic Transcriptional Silencing and P-TEFb Restriction , 2010, Journal of Virology.

[43]  A. August,et al.  Combinatorial Signals from CD28 Differentially Regulate Human Immunodeficiency Virus Transcription in T Cells* , 2010, The Journal of Biological Chemistry.

[44]  T. Okamoto,et al.  Involvement of Histone H3 Lysine 9 (H3K9) Methyltransferase G9a in the Maintenance of HIV-1 Latency and Its Reactivation by BIX01294* , 2010, The Journal of Biological Chemistry.

[45]  E. Verdin,et al.  The Cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat, and enhances HIV transcription. , 2010, Cell host & microbe.

[46]  M. Cleary,et al.  A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription. , 2010, Cancer cell.

[47]  A. Shilatifard,et al.  AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia. , 2010, Molecular cell.

[48]  C. Van Lint,et al.  Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies , 2009, Retrovirology.

[49]  Qiang Zhou,et al.  A capping-independent function of MePCE in stabilizing 7SK snRNA and facilitating the assembly of 7SK snRNP , 2009, Nucleic acids research.

[50]  M. Geyer,et al.  Structures of the Dual Bromodomains of the P-TEFb-activating Protein Brd4 at Atomic Resolution* , 2009, The Journal of Biological Chemistry.

[51]  D. Harrich,et al.  Arginine Methylation Increases the Stability of Human Immunodeficiency Virus Type 1 Tat , 2009, Journal of Virology.

[52]  C. Van Lint,et al.  CpG Methylation Controls Reactivation of HIV from Latency , 2009, PLoS pathogens.

[53]  R. Medzhitov,et al.  Control of Inducible Gene Expression by Signal-Dependent Transcriptional Elongation , 2009, Cell.

[54]  R. Slany.  The molecular biology of mixed lineage leukemia , 2009, Haematologica.

[55]  E. Verdin,et al.  Epigenetic Regulation of HIV-1 Latency by Cytosine Methylation , 2009, PLoS pathogens.

[56]  E. Loret,et al.  What does the structure-function relationship of the HIV-1 Tat protein teach us about developing an AIDS vaccine? , 2009, Retrovirology.

[57]  Angelika Pedal,et al.  Acetylation of cyclin T1 regulates the equilibrium between active and inactive P‐TEFb in cells , 2009, The EMBO journal.

[58]  S. Amente,et al.  Camptothecin releases P-TEFb from the inactive 7SK snRNP complex , 2009, Cell cycle.

[59]  Amy S. Espeseth,et al.  A Limited Group of Class I Histone Deacetylases Acts To Repress Human Immunodeficiency Virus Type 1 Expression , 2009, Journal of Virology.

[60]  D. Hazuda,et al.  The Challenge of Finding a Cure for HIV Infection , 2009, Science.

[61]  A. Frankel,et al.  Tat acetylation modulates assembly of a viral-host RNA–protein transcription complex , 2009, Proceedings of the National Academy of Sciences.

[62]  Angelo D. Favia,et al.  Protein promiscuity and its implications for biotechnology , 2009, Nature Biotechnology.

[63]  A. Rice,et al.  miR-198 Inhibits HIV-1 Gene Expression and Replication in Monocytes and Its Mechanism of Action Appears To Involve Repression of Cyclin T1 , 2009, PLoS pathogens.

[64]  Priya S. Shah,et al.  Control of Stochastic Gene Expression by Host Factors at the HIV Promoter , 2009, PLoS pathogens.

[65]  T. Umehara,et al.  Solution structure of the extraterminal domain of the bromodomain‐containing protein BRD4 , 2008, Protein science : a publication of the Protein Society.

[66]  A. Rice,et al.  Phosphatase PPM1A Regulates Phosphorylation of Thr-186 in the Cdk9 T-loop* , 2008, Journal of Biological Chemistry.

[67]  M. Geyer,et al.  Structural insights into the Cyclin T1–Tat–TAR RNA transcription activation complex from EIAV , 2008, Nature Structural &Molecular Biology.

[68]  A. Trkola,et al.  HIV rebounds from latently infected cells, rather than from continuing low-level replication , 2008, Proceedings of the National Academy of Sciences.

[69]  J. Karn,et al.  Epigenetic Silencing of Human Immunodeficiency Virus (HIV) Transcription by Formation of Restrictive Chromatin Structures at the Viral Long Terminal Repeat Drives the Progressive Entry of HIV into Latency , 2008, Journal of Virology.

[70]  L. Johnson,et al.  The structure of P‐TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation , 2008, The EMBO journal.

[71]  K. Jones,et al.  The multi-tasking P-TEFb complex. , 2008, Current opinion in cell biology.

[72]  R. Berro,et al.  Lysine methylation of HIV-1 Tat regulates transcriptional activity of the viral LTR , 2008, Retrovirology.

[73]  Qiang Zhou,et al.  PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling. , 2008, Genes & development.

[74]  N. Jahchan,et al.  A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis. , 2008, Molecular cell.

[75]  Marrije R Buist,et al.  Gene expression in early stage cervical cancer. , 2008, Gynecologic oncology.

[76]  B. Coulombe,et al.  LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated , 2008, Nucleic acids research.

[77]  J. Karn,et al.  CBF‐1 promotes transcriptional silencing during the establishment of HIV‐1 latency , 2007, The EMBO journal.

[78]  Ruchir Shah,et al.  RNA polymerase is poised for activation across the genome , 2007, Nature Genetics.

[79]  Qiang Zhou,et al.  Brd4 Recruits P-TEFb to Chromosomes at Late Mitosis To Promote G1 Gene Expression and Cell Cycle Progression , 2007, Molecular and Cellular Biology.

[80]  Tina Lenasi,et al.  HMBA Releases P-TEFb from HEXIM1 and 7SK snRNA via PI3K/Akt and Activates HIV Transcription , 2007, PLoS pathogens.

[81]  M. L. Simpson,et al.  Transient-mediated fate determination in a transcriptional circuit of HIV , 2007, Nature Genetics.

[82]  S. Grzesiek,et al.  Structure of the Cyclin T binding domain of Hexim1 and molecular basis for its recognition of P-TEFb , 2007, Proceedings of the National Academy of Sciences.

[83]  T. Mahmoudi,et al.  Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription , 2007, Proceedings of the National Academy of Sciences.

[84]  Amy S. Espeseth,et al.  c-Myc and Sp1 Contribute to Proviral Latency by Recruiting Histone Deacetylase 1 to the Human Immunodeficiency Virus Type 1 Promoter , 2007, Journal of Virology.

[85]  Mathieu Blanchette,et al.  Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. , 2007, Molecular cell.

[86]  R. Jaenisch,et al.  A Chromatin Landmark and Transcription Initiation at Most Promoters in Human Cells , 2007, Cell.

[87]  O. Bensaude,et al.  Inhibition of HIV-1 replication by P-TEFb inhibitors DRB, seliciclib and flavopiridol correlates with release of free P-TEFb from the large, inactive form of the complex , 2007, Retrovirology.

[88]  D. Price,et al.  Manipulation of P-TEFb control machinery by HIV: recruitment of P-TEFb from the large form by Tat and binding of HEXIM1 to TAR , 2007, Nucleic acids research.

[89]  Shwu‐Yuan Wu,et al.  The Double Bromodomain-containing Chromatin Adaptor Brd4 and Transcriptional Regulation* , 2007, Journal of Biological Chemistry.

[90]  W. Greene,et al.  Sustained Induction of NF-κB Is Required for Efficient Expression of Latent Human Immunodeficiency Virus Type 1 , 2007, Journal of Virology.

[91]  Y. Takebe,et al.  Inhibiting lentiviral replication by HEXIM1, a cellular negative regulator of the CDK9/cyclin T complex , 2007, AIDS.

[92]  Qiang Zhou,et al.  Tat competes with HEXIM1 to increase the active pool of P-TEFb for HIV-1 transcription , 2007, Nucleic acids research.

[93]  L. Linares,et al.  The proteasome regulates HIV-1 transcription by both proteolytic and nonproteolytic mechanisms. , 2007, Molecular cell.

[94]  S. Richard,et al.  Arginine Methylation of the Human Immunodeficiency Virus Type 1 Tat Protein by PRMT6 Negatively Affects Tat Interactions with both Cyclin T1 and the Tat Transactivation Region , 2007, Journal of Virology.

[95]  F. Dequiedt,et al.  Recruitment of chromatin‐modifying enzymes by CTIP2 promotes HIV‐1 transcriptional silencing , 2007, The EMBO journal.

[96]  A. Knezevich,et al.  Suv39H1 and HP1γ are responsible for chromatin‐mediated HIV‐1 transcriptional silencing and post‐integration latency , 2007, The EMBO journal.

[97]  Sergei Nekhai,et al.  Phosphorylation of HIV-1 Tat by CDK2 in HIV-1 transcription , 2006, Retrovirology.

[98]  Qiang Zhou,et al.  Modulation of a P-TEFb Functional Equilibrium for the Global Control of Cell Growth and Differentiation , 2006, Molecular and Cellular Biology.

[99]  Qiang Zhou,et al.  The Yin and Yang of P-TEFb Regulation: Implications for Human Immunodeficiency Virus Gene Expression and Global Control of Cell Growth and Differentiation , 2006, Microbiology and Molecular Biology Reviews.

[100]  F. Kashanchi,et al.  Effect of SWI/SNF chromatin remodeling complex on HIV-1 Tat activated transcription , 2006, Retrovirology.

[101]  Jared E. Toettcher,et al.  Supplemental Data: Stochastic Gene Expression in a Lentiviral Positive Feedback Loop: HIV-1 Tat Fluctuations Drive Phenotypic Diversity , 2006, q-bio/0608003.

[102]  Eric Verdin,et al.  The SWI/SNF Chromatin-remodeling Complex Is a Cofactor for Tat Transactivation of the HIV Promoter* , 2006, Journal of Biological Chemistry.

[103]  T. Okamoto,et al.  Transcriptional Repression of Human Immunodeficiency Virus Type 1 by AP-4* , 2006, Journal of Biological Chemistry.

[104]  R. Benarous,et al.  Requirement for SWI/SNF chromatin‐remodeling complex in Tat‐mediated activation of the HIV‐1 promoter , 2006, The EMBO journal.

[105]  E. Verdin,et al.  NF‐κB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation , 2006, The EMBO journal.

[106]  S. Nekhai,et al.  Nuclear Targeting of Protein Phosphatase-1 by HIV-1 Tat Protein* , 2005, Journal of Biological Chemistry.

[107]  O. Bensaude,et al.  Transcription-dependent Association of Multiple Positive Transcription Elongation Factor Units to a HEXIM Multimer* , 2005, Journal of Biological Chemistry.

[108]  Qiang Zhou,et al.  Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4. , 2005, Molecular cell.

[109]  J. Brady,et al.  The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription. , 2005, Molecular cell.

[110]  Dongmei Cheng,et al.  Analysis of the Large Inactive P-TEFb Complex Indicates That It Contains One 7SK Molecule, a Dimer of HEXIM1 or HEXIM2, and Two P-TEFb Molecules Containing Cdk9 Phosphorylated at Threonine 186* , 2005, Journal of Biological Chemistry.

[111]  B. Peterlin,et al.  Identification of a Cyclin T-Binding Domain in Hexim1 and Biochemical Analysis of Its Binding Competition with HIV-1 Tat* , 2005, Journal of Biological Chemistry.

[112]  C. Van Lint,et al.  COUP-TF interacting protein 2 represses the initial phase of HIV-1 gene transcription in human microglial cells , 2005, Nucleic acids research.

[113]  Qintong Li,et al.  HEXIM2, a HEXIM1-related Protein, Regulates Positive Transcription Elongation Factor b through Association with 7SK* , 2005, Journal of Biological Chemistry.

[114]  Qiang Zhou,et al.  Compensatory Contributions of HEXIM1 and HEXIM2 in Maintaining the Balance of Active and Inactive Positive Transcription Elongation Factor b Complexes for Control of Transcription* , 2005, Journal of Biological Chemistry.

[115]  D. Harrich,et al.  Phosphorylation of HIV Tat by PKR increases interaction with TAR RNA and enhances transcription , 2005, Virology Journal.

[116]  A. L. Remoli,et al.  Role of Acetylases and Deacetylase Inhibitors in IRF‐1‐Mediated HIV‐1 Long Terminal Repeat Transcription , 2004, Annals of the New York Academy of Sciences.

[117]  Qiang Zhou,et al.  A Human Immunodeficiency Virus Type 1 Tat-Like Arginine-Rich RNA-Binding Domain Is Essential for HEXIM1 To Inhibit RNA Polymerase II Transcription through 7SK snRNA-Mediated Inactivation of P-TEFb , 2004, Molecular and Cellular Biology.

[118]  G. Almouzni,et al.  Bromodomains in living cells participate in deciphering the histone code. , 2004, Trends in cell biology.

[119]  Qiang Zhou,et al.  Phosphorylated Positive Transcription Elongation Factor b (P-TEFb) Is Tagged for Inhibition through Association with 7SK snRNA* , 2004, Journal of Biological Chemistry.

[120]  A. Frankel,et al.  Evidence for conformational flexibility in the Tat-TAR recognition motif of cyclin T1. , 2004, Virology.

[121]  M. Giacca,et al.  Regulation of HIV‐1 gene expression by histone acetylation and factor recruitment at the LTR promoter , 2003, The EMBO journal.

[122]  P. Kloetzel,et al.  Human immunodeficiency virus‐1 Tat protein interacts with distinct proteasomal α and β subunits , 2003 .

[123]  A. Link,et al.  Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA. , 2003, Molecular cell.

[124]  A. Rice,et al.  Regulation of TAK/P-TEFb in CD4+ T lymphocytes and macrophages. , 2003, Current HIV research.

[125]  K. Jeang,et al.  A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter , 2003, Nature Cell Biology.

[126]  Tom Misteli,et al.  The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[127]  O. Bensaude,et al.  MAQ1 and 7SK RNA Interact with CDK9/Cyclin T Complexes in a Transcription-Dependent Manner , 2003, Molecular and Cellular Biology.

[128]  V. Kiermer,et al.  Acetylation of Tat defines a cyclinT1-independent step in HIV transactivation. , 2003, Molecular cell.

[129]  D. Price,et al.  Identification of a novel isoform of Cdk9. , 2003, Gene.

[130]  K. Jeang,et al.  Differential acetylation of Tat coordinates its interaction with the co‐activators cyclin T1 and PCAF , 2002, The EMBO journal.

[131]  Qiang Zhou,et al.  HIV‐1 Tat targets microtubules to induce apoptosis, a process promoted by the pro‐apoptotic Bcl‐2 relative Bim , 2002, The EMBO journal.

[132]  J. Workman,et al.  Function and Selectivity of Bromodomains in Anchoring Chromatin-Modifying Complexes to Promoter Nucleosomes , 2002, Cell.

[133]  Dimitris Thanos,et al.  Deciphering the Transcriptional Histone Acetylation Code for a Human Gene , 2002, Cell.

[134]  A. Giordano,et al.  Activation and function of cyclin T–Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy , 2002, Nature Medicine.

[135]  V. Kiermer,et al.  Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain , 2002, The EMBO journal.

[136]  Xiao-Fan Wang,et al.  HDAC6 is a microtubule-associated deacetylase , 2002, Nature.

[137]  D. Margolis,et al.  Counterregulation of Chromatin Deacetylation and Histone Deacetylase Occupancy at the Integrated Promoter of Human Immunodeficiency Virus Type 1 (HIV-1) by the HIV-1 Repressor YY1 and HIV-1 Activator Tat , 2002, Molecular and Cellular Biology.

[138]  T. Kouzarides.  Histone methylation in transcriptional control. , 2002, Current opinion in genetics & development.

[139]  A. Rice,et al.  Induction of TAK (Cyclin T1/P-TEFb) in Purified Resting CD4+ T Lymphocytes by Combination of Cytokines , 2001, Journal of Virology.

[140]  Tamás Kiss,et al.  7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes , 2001, Nature.

[141]  Qiang Zhou,et al.  The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription , 2001, Nature.

[142]  Eric Verdin,et al.  Duration of Nuclear NF-κB Action Regulated by Reversible Acetylation , 2001, Science.

[143]  A. Favier,et al.  The Histone Acetyltransferase, hGCN5, Interacts with and Acetylates the HIV Transactivator, Tat* , 2001, The Journal of Biological Chemistry.

[144]  E. Sausville,et al.  Flavopiridol Inhibits P-TEFb and Blocks HIV-1 Replication* , 2000, The Journal of Biological Chemistry.

[145]  J. Lippincott-Schwartz,et al.  A Bromodomain Protein, MCAP, Associates with Mitotic Chromosomes and Affects G2-to-M Transition , 2000, Molecular and Cellular Biology.

[146]  Yang Shi,et al.  The Human Factors YY1 and LSF Repress the Human Immunodeficiency Virus Type 1 Long Terminal Repeat via Recruitment of Histone Deacetylase 1 , 2000, Journal of Virology.

[147]  Junmin Peng,et al.  Tat Modifies the Activity of CDK9 To Phosphorylate Serine 5 of the RNA Polymerase II Carboxyl-Terminal Domain during Human Immunodeficiency Virus Type 1 Transcription , 2000, Molecular and Cellular Biology.

[148]  E. Verdin,et al.  Acetylation of the HIV-1 Tat protein by p300 is important for its transcriptional activity , 1999, Current Biology.

[149]  Junmin Peng,et al.  Cyclin K Functions as a CDK9 Regulatory Subunit and Participates in RNA Polymerase II Transcription* , 1999, The Journal of Biological Chemistry.

[150]  A. Burny,et al.  HIV‐1 Tat transcriptional activity is regulated by acetylation , 1999, The EMBO journal.

[151]  B. Cullen,et al.  Recruitment of cyclin T1/P-TEFb to an HIV type 1 long terminal repeat promoter proximal RNA target is both necessary and sufficient for full activation of transcription. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[152]  James M. Roberts,et al.  CDK inhibitors: positive and negative regulators of G1-phase progression. , 1999, Genes & development.

[153]  O. Bensaude,et al.  The Transcriptional Inhibitors, Actinomycin D and α-Amanitin, Activate the HIV-1 Promoter and Favor Phosphorylation of the RNA Polymerase II C-terminal Domain* , 1999, The Journal of Biological Chemistry.

[154]  J. Lisziewicz,et al.  Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy , 1999, Nature Medicine.

[155]  R. Gaynor,et al.  Cyclin T1 domains involved in complex formation with Tat and TAR RNA are critical for tat-activation. , 1999, Journal of molecular biology.

[156]  J. Karn,et al.  Stimulation of Tat‐associated kinase‐independent transcriptional elongation from the human immunodeficiency virus type‐1 long terminal repeat by a cellular enhancer , 1999, The EMBO journal.

[157]  B. Peterlin,et al.  Interactions between human cyclin T, Tat, and the transactivation response element (TAR) are disrupted by a cysteine to tyrosine substitution found in mouse cyclin T. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[158]  M. Garber,et al.  The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein. , 1998, Genes & development.

[159]  M. Giacca,et al.  HIV-1 tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[160]  K. Jeang,et al.  Activation of Integrated Provirus Requires Histone Acetyltransferase , 1998, The Journal of Biological Chemistry.

[161]  A. Rao,et al.  Nuclear Factor of Activated T Cells (NFAT)-dependent Transactivation Regulated by the Coactivators p300/CREB-binding Protein (CBP) , 1998, The Journal of experimental medicine.

[162]  G. Nabel,et al.  Modulation of cytokine‐induced HIV gene expression by competitive binding of transcription factors to the coactivator p300 , 1998, The EMBO journal.

[163]  J. Milton,et al.  Identification of multiple cyclin subunits of human P-TEFb. , 1998, Genes & development.

[164]  Ping Wei,et al.  A Novel CDK9-Associated C-Type Cyclin Interacts Directly with HIV-1 Tat and Mediates Its High-Affinity, Loop-Specific Binding to TAR RNA , 1998, Cell.

[165]  Joël Janin,et al.  Specific versus non-specific contacts in protein crystals , 1997, Nature Structural Biology.

[166]  D. Hazuda,et al.  P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro. , 1997, Genes & development.

[167]  M. Mathews,et al.  Transcription elongation factor P-TEFb is required for HIV-1 tat transactivation in vitro. , 1997, Genes & development.

[168]  F. Jeanmougin,et al.  The bromodomain revisited. , 1997, Trends in biochemical sciences.

[169]  D. Reinberg,et al.  The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme , 1997, Molecular and cellular biology.

[170]  A. Shilatifard,et al.  An RNA Polymerase II Elongation Factor Encoded by the Human ELL Gene , 1996, Science.

[171]  C. Van Lint,et al.  Transcriptional activation and chromatin remodeling of the HIV‐1 promoter in response to histone acetylation. , 1996, The EMBO journal.

[172]  M. Kazatchkine,et al.  Triggering of complement receptors CR1 (CD35) and CR3 (CD11b/CD18) induces nuclear translocation of NF-kappa B (p50/p65) in human monocytes and enhances viral replication in HIV-infected monocytic cells. , 1995, Journal of immunology.

[173]  A. Rice,et al.  Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor , 1995, Journal of virology.

[174]  O. Bagasra,et al.  Association of alterations in NF-kappa B moieties with HIV type 1 proviral latency in certain monocytic cells. , 1994, AIDS research and human retroviruses.

[175]  D. Margolis,et al.  Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production , 1994, Journal of virology.

[176]  A. Rice,et al.  Specific interaction of the human immunodeficiency virus Tat proteins with a cellular protein kinase. , 1993, Virology.

[177]  C. Van Lint,et al.  Chromatin disruption in the promoter of human immunodeficiency virus type 1 during transcriptional activation. , 1993, The EMBO journal.

[178]  P. Sharp,et al.  HIV‐1 Tat protein promotes formation of more‐processive elongation complexes. , 1991, The EMBO journal.

[179]  N. Sonenberg,et al.  A bulge structure in HIV-1 TAR RNA is required for Tat binding and Tat-mediated trans-activation. , 1990, Disease markers.

[180]  P. Sharp,et al.  Identification and characterization of a HeLa nuclear protein that specifically binds to the trans-activation-response (TAR) element of human immunodeficiency virus. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[181]  P. Luciw,et al.  Structure, sequence, and position of the stem-loop in tar determine transcriptional elongation by tat through the HIV-1 long terminal repeat. , 1989, Genes & development.

[182]  Carl O. Pabo,et al.  Cellular uptake of the tat protein from human immunodeficiency virus , 1988, Cell.

[183]  Maurice Green,et al.  Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein , 1988, Cell.

[184]  Eric C. Holland,et al.  HIV-1 tat trans-activation requires the loop sequence within tar , 1988, Nature.

[185]  C. Debouck,et al.  Activation of human immunodeficiency virus type 1 by DNA damage in human cells , 1988, Nature.

[186]  P. Luciw,et al.  Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product , 1987, Nature.

[187]  B. Peterlin,et al.  Control of RNA initiation and elongation at the HIV-1 promoter. , 1994, Annual review of biochemistry.

[188]  M. Bolognesi,et al.  Function and Structure of Inherently Disordered Proteins This Review Comes from a Themed Issue on Proteins Edited Prediction of Non-folding Proteins and Regions Frequency of Disordered Regions Protein Evolution Partitioning Unstructured Proteins and Regions into Groups Involvement of Inherently Diso , 2022 .