Identification of eczema clusters and their association with filaggrin and atopic comorbidities: analysis of five birth cohorts

Using multidimensional variables may capture eczema development and derive stable and internally homogeneous clusters. However, deriving homogeneous symptom clusters does not necessarily mean that these are underpinned by completely unique mechanisms.

[1]  P. Cullinan,et al.  Evolution of Eczema, Wheeze and Rhinitis from Infancy to Early Adulthood: Four Birth Cohort Studies. , 2022, American journal of respiratory and critical care medicine.

[2]  J. Silverberg,et al.  Evaluating the Longitudinal Course of Atopic Dermatitis: Implications for Clinical Practice , 2022, American Journal of Clinical Dermatology.

[3]  A. Lowe,et al.  Establishing subclasses of childhood eczema, their risk factors and prognosis , 2022, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[4]  P. Cullinan,et al.  Modeling Wheezing Spells Identifies Phenotypes with Different Outcomes and Genetic Associates , 2022, American journal of respiratory and critical care medicine.

[5]  A. Custovic,et al.  Data‐driven research on eczema: Systematic characterization of the field and recommendations for the future , 2022, medRxiv.

[6]  W. Karmaus,et al.  Sex‐specific developmental trajectories of eczema from infancy to age 26 years: A birth cohort study , 2021, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[7]  Lisa J. Martin,et al.  Longitudinal atopic dermatitis endotypes: An atopic march paradigm that includes Black children. , 2021, The Journal of allergy and clinical immunology.

[8]  A. Custovic,et al.  Modelling trajectories of parentally reported and physician‐confirmed atopic dermatitis in a birth cohort study * , 2021, The British journal of dermatology.

[9]  K. Godfrey,et al.  Atopic dermatitis trajectories to age 8 years in the GUSTO cohort , 2021, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[10]  S. Filippi,et al.  Atopic dermatitis or eczema? Consequences of ambiguity in disease name for biomedical literature mining , 2021, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[11]  L. Smeeth,et al.  Four childhood atopic dermatitis subtypes identified from trajectory and severity of disease and internally validated in a large UK birth cohort , 2021, The British journal of dermatology.

[12]  D. Nicolae,et al.  Chromosome 17q12-21 Variants are Associated with Multiple Wheezing Phenotypes in Childhood. , 2021, American journal of respiratory and critical care medicine.

[13]  A. Custovic,et al.  Atopic phenotypes and their implication in the atopic march , 2020, Expert review of clinical immunology.

[14]  A. Custovic,et al.  Early-life inhalant allergen exposure, filaggrin genotype, and the development of sensitization from infancy to adolescence , 2020, The Journal of allergy and clinical immunology.

[15]  P. Cullinan,et al.  Distinguishing Wheezing Phenotypes from Infancy to Adolescence. A Pooled Analysis of Five Birth Cohorts , 2019, Annals of the American Thoracic Society.

[16]  P. Cullinan,et al.  Different definitions of atopic dermatitis: impact on prevalence estimates and associated risk factors† , 2019, The British journal of dermatology.

[17]  A. Custovic,et al.  Causes of variability in latent phenotypes of childhood wheeze , 2019, The Journal of allergy and clinical immunology.

[18]  L. Duijts,et al.  Most associations of early‐life environmental exposures and genetic risk factors poorly differentiate between eczema phenotypes: the Generation R Study† , 2019, The British journal of dermatology.

[19]  A. Custovic,et al.  Classification of Pediatric Asthma: From Phenotype Discovery to Clinical Practice , 2018, Front. Pediatr..

[20]  G. Roberts,et al.  Cohort Profile: The Isle Of Wight Whole Population Birth Cohort (IOWBC). , 2018, International journal of epidemiology.

[21]  J. Silverberg,et al.  What's in a name? Atopic dermatitis or atopic eczema, but not eczema alone , 2017, Allergy.

[22]  David M. Evans,et al.  Identification of atopic dermatitis subgroups in children from 2 longitudinal birth cohorts , 2017, Pediatrics.

[23]  M. Ege,et al.  Phenotypes of Atopic Dermatitis Depending on the Timing of Onset and Progression in Childhood , 2017, JAMA pediatrics.

[24]  Hadley Wickham,et al.  ggplot2 - Elegant Graphics for Data Analysis (2nd Edition) , 2017 .

[25]  J. Silverberg,et al.  Atopic dermatitis, atopic eczema, or eczema? A systematic review, meta‐analysis, and recommendation for uniform use of ‘atopic dermatitis’ , 2016, Allergy.

[26]  Iain Buchan,et al.  The Study Team for Early Life Asthma Research (STELAR) consortium ‘Asthma e-lab’: team science bringing data, methods and investigators together , 2015, Thorax.

[27]  Xavier Basagaña,et al.  A framework for multiple imputation in cluster analysis. , 2013, American journal of epidemiology.

[28]  E. Simpson,et al.  How should an incident case of atopic dermatitis be defined? A systematic review of primary prevention studies. , 2012, The Journal of allergy and clinical immunology.

[29]  D. Lawlor,et al.  Cohort Profile: The Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort , 2012, International journal of epidemiology.

[30]  Y. Yang,et al.  Exclusive breastfeeding and incident atopic dermatitis in childhood: a systematic review and meta‐analysis of prospective cohort studies , 2009, The British journal of dermatology.

[31]  P. Rousseeuw,et al.  Partitioning Around Medoids (Program PAM) , 2008 .

[32]  G. Mcneill,et al.  Antioxidant intake in pregnancy in relation to wheeze and eczema in the first two years of life. , 2005, American journal of respiratory and critical care medicine.

[33]  P. Cullinan,et al.  Early allergen exposure, skin prick responses, and atopic wheeze at age 5 in English children: a cohort study , 2004, Thorax.

[34]  A. Woodcock,et al.  The National Asthma Campaign Manchester Asthma and Allergy Study , 2002, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[35]  Subir Ghosh,et al.  Statistical Analysis With Missing Data , 1988 .

[36]  G. Rajka,et al.  Diagnostic Features of Atopic Dermatitis , 1980, Acta Dermato-Venereologica.

[37]  D. Wishart,et al.  k-Means Clustering with Outlier Detection, Mixed Variables and Missing Values , 2003 .