Inflammatory myofibroblastic tumor from the greater omentum in children: A rare case report

Inflammatory myofibroblastic tumor (IMT) prevalence is less than one in a million. Anaplastic lymphoma kinase (ALK)-positive IMT in the greater omentum and with a diameter greater than 8 cm is extremely rare. Here, we present a case and provide a brief literature review. A 4-year-old female was referred to our hospital with a 1-month history of intermittent fever. Computed tomography revealed a 6.4 × 5.5 × 6.5-cm lesion between the spleen and stomach. During the operation, we confirmed that the mass originated in the greater omentum and completely resected the mass, achieving a negative margin. The maximum cross-sectional area of the tumor after surgery was 8.3 × 7.5 cm. The immunohistochemistry result of this IMT was ALK (+), S100 (−), Ki-67+ (20%), Desmin (+), CD21 (−), CD35 (+), Vim (+), and SMA (+). The final pathology was IMT. No local recurrence or metastasis has been observed in the 8 months of follow-up.

[1]  A. Korzyńska,et al.  What do we know about inflammatory myofibroblastic tumors? - A systematic review. , 2022, Advances in medical sciences.

[2]  A. Ferrari,et al.  Inflammatory myofibroblastic tumor: The experience of the European pediatric Soft Tissue Sarcoma Study Group (EpSSG). , 2020, European journal of cancer.

[3]  E. Oliva,et al.  Inflammatory myofibroblastic tumor of the uterus: a clinicopathological, immunohistochemical, and molecular analysis of 13 cases highlighting their broad morphologic spectrum , 2017, Modern Pathology.

[4]  Jen-Chieh Lee,et al.  Uterine Inflammatory Myofibroblastic Tumors Frequently Harbor ALK Fusions With IGFBP5 and THBS1 , 2017, The American journal of surgical pathology.

[5]  V. Surabhi,et al.  Inflammatory Myofibroblastic Tumors: Current Update. , 2016, The Radiologic clinics of North America.

[6]  Lingli Tu,et al.  Management of rectal inflammatory myofibroblastic tumor recurrence. , 2014, Journal of Cancer Research and Therapeutics.

[7]  C. Fletcher,et al.  WHO classification of soft tissue tumours: an update based on the 2013 (4th) edition , 2014, Pathology.

[8]  Jian Sun,et al.  Head and neck inflammatory myofibroblastic tumor (IMT): evaluation of clinicopathologic and prognostic features. , 2012, Oral oncology.

[9]  S. Menon,et al.  Fluoro-deoxy glucose-avid endobronchial inflammatory myofibroblastic tumor mimicking bronchial malignancy: report of a case. , 2011, Journal of cancer research and therapeutics.

[10]  F. Callea,et al.  Unresectable multifocal omental and peritoneal inflammatory myofibroblastic tumor in a child: revisiting the role of adjuvant therapy. , 2011, Journal of pediatric surgery.

[11]  A. Sezer,et al.  Inflammatory myofibroblastic tumor presenting as an abdominal wall mass in an adult patient. , 2010, Journal of Cancer Research and Therapeutics.

[12]  C. Fletcher,et al.  Inflammatory Myofibroblastic Tumor: Comparison of Clinicopathologic, Histologic, and Immunohistochemical Features Including ALK Expression in Atypical and Aggressive Cases , 2007, The American journal of surgical pathology.

[13]  C. Fletcher.  The evolving classification of soft tissue tumours: an update based on the new WHO classification , 2006, Histopathology.

[14]  A. Kaipainen,et al.  The rationale for nonsteroidal anti-inflammatory drug therapy for inflammatory myofibroblastic tumors: a Children's Oncology Group study. , 2005, Journal of pediatric surgery.

[15]  Louis P. Dehner,et al.  Extrapulmonary Inflammatory Myofibroblastic Tumor (Inflammatory Pseudotumor) A Clinicopathologic and Immunohistochemical Study of 84 Cases , 1995, The American journal of surgical pathology.

[16]  F. Enzinger,et al.  Inflammatory Fibrosarcoma of the Mesentery and Retroperitoneum: A Tumor Closely Simulating Inflammatory Pseudotumor , 1991, The American journal of surgical pathology.

[17]  H. Brunn.  two interesting benign lung tumors of contradictory histopathology ; remarks on necessity for maintaining chest tumor registry , 1939 .