Retrograde amnesia due to spreading cortical depression: Paradoxical effect of shock-SD interval

The effect of spreading cortical depression (SD) on a previously administered one-trial passive avoidance problem was studies in 75 rats. A nonmonotonic relation between the degree of amnesia and the shock-SD interval was observed with greatest amnesia at an intermediate interval. These results are not consistent with a simple consolidation hypothesis but can be explained by a three stage information storage process.

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