abnormalities in first-episode psychosis Duration of prodromal phase and severity of volumetric

Background First-episodepsychosisistypicallyprecededbyaprodromeinwhichthereisdeteriorationinglobalandsocialfufunnccttionioniningg..Aims To examinewhether thedurationoftheprodromalphaseinfluencesgreyandwhitemattervolumesattheonsetofpspsyycchhososiiss..MMetethodhodss Eighty-twopeoplewerescannedusingmagneticresonanceimagingwhentheydevelopedafirstepisodeofpsychosis.Thedurationoftheprodromalphasewasestimatedfromdetailedinterviewsandmedicalrecords.Voxel-basedmorphometrywasusedtoassessneuroanatomicalabnormalities.RReesusulltsts Alongprodromalphasewasassociatedwithsmallergreymattervolumesinthecingulate, frontalandleftinsularcortex,andwithlesswhitematterinsularcortex, andwithlesswhitemattervolumebilaterallyinthesuperiorlongitudinalanduncinatefasciculiandthecingulum.Conclusions Theseverityofvolumetricabnormalitiesinfirst-episodepsychosiswasgreaterinthosewithalongprprooddrroome.me.Declarationof interest None.FundingdetailedinAcknowledgements.Fundingdetailedin Acknowledgements.

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