A study of nonbacterial agents of acute lower respiratory tract infection in Thai children.

From January 1986 to December 1987, 596 children less than 5 years of age with lower respiratory tract infection (LRI)--manifested as laryngitis, croup, bronchitis, bronchiolitis, and pneumonia--were studied for evidence of infection with respiratory tract viruses Mycoplasma pneumoniae, and Chlamydia trachomatis. Of the 596 children in the study, 315 were ambulatory and 281 were hospitalized. Virologic studies included isolation and rapid diagnosis of virus from specimens of nasopharyngeal aspirate (NPA) and serologic studies of blood samples. Cultures of NPA for C. trachomatis were performed for children less than 6 months of age who had pneumonia. Of the LRI cases, 45% were associated with viral infections of the respiratory tract and 12.1% were associated with C. trachomatis. Respiratory syncytial virus (RSV) accounted for 45.2% of infections with viral agents and was associated with acute bronchitis, acute bronchiolitis, and pneumonia. Parainfluenza type 3 virus was the most common virus found in conjunction with laryngitis and croup. The incidence of infections due to RSV peaked in July and August, while that of infections due to parainfluenza viruses peaked in February and March; influenza viruses and adenoviruses were isolated throughout the year.

[1]  J. Dugué,et al.  Viral and chlamydial etiology of acute infections of the lower respiratory tract in Colombian children. , 1988, The Pediatric infectious disease journal.

[2]  D. P. Davies,et al.  Seasonal patterns of respiratory syncytial virus infection in Hong Kong: a preliminary report. , 1987, The Journal of infectious diseases.

[3]  F. W. Denny,et al.  Acute lower respiratory tract infections in nonhospitalized children. , 1986, The Journal of pediatrics.

[4]  P. Arstila,et al.  Viral diagnoses using the rapid immunofluorescence technique and epidemiological implications of acute respiratory infections among children in different European countries. , 1984, Bulletin of the World Health Organization.

[5]  D. Gwatkin.  How many die? A set of demographic estimates of the annual number of infant and child deaths in the world. , 1980, American journal of public health.

[6]  A. Bulla,et al.  Acute respiratory infections: a review. , 1978, Bulletin of the World Health Organization.

[7]  M. Beem,et al.  Respiratory-tract colonization and a distinctive pneumonia syndrome in infants infected with Chlamydia trachomatis. , 1977, The New England journal of medicine.

[8]  C B Hall,et al.  Respiratory syncytial virus infections within families. , 1976, The New England journal of medicine.

[9]  R. Chanock,et al.  Epidemiology of respiratory syncytial virus infection in Washington, D.C. I. Importance of the virus in different respiratory tract disease syndromes and temporal distribution of infection. , 1973, American journal of epidemiology.

[10]  M. Cooney,et al.  Viral and mycoplasmal pneumonia in a prepaid medical care group during an eight-year period. , 1973, American journal of epidemiology.

[11]  H. E. Noyes,et al.  The etiology of respiratory tract infections in a tropical country. , 1973, American journal of epidemiology.

[12]  A. Monto,et al.  The Tecumseh study of respiratory illness. 3. Incidence and periodicity of respiratory syncytial virus and Mycoplasma pneumoniae infections. , 1971, American journal of epidemiology.

[13]  M. Cooney,et al.  Epidemiology of viral and mycoplasmal agents associated with childhood lower respiratory illness in a civilian population. , 1971, The Journal of pediatrics.