Bioengineered models to study tumor dormancy

[1]  E. Sahai,et al.  In vitro Models of Breast Cancer Metastatic Dormancy , 2020, Frontiers in Cell and Developmental Biology.

[2]  Luong T H Nguyen,et al.  Surface engineering within a microchannel for hydrodynamic and self-assembled cell patterning. , 2020, Biomicrofluidics.

[3]  J. H. Slater,et al.  Fabrication, characterization, and implementation of engineered hydrogels for controlling breast cancer cell phenotype and dormancy , 2019, MethodsX.

[4]  M. Manjili,et al.  Tumor Cell Dormancy: Threat or Opportunity in the Fight against Cancer , 2018, Cancers.

[5]  Daniel E. Lefever,et al.  Harnessing Human Microphysiology Systems as Key Experimental Models for Quantitative Systems Pharmacology. , 2019, Handbook of experimental pharmacology.

[6]  Samira M. Azarin,et al.  A facile in vitro platform to study cancer cell dormancy under hypoxic microenvironments using CoCl2 , 2018, Journal of Biological Engineering.

[7]  Le Zhang,et al.  Fibrin Stiffness Mediates Dormancy of Tumor-Repopulating Cells via a Cdc42-Driven Tet2 Epigenetic Program. , 2018, Cancer research.

[8]  Kriengsak Lirdprapamongkol,et al.  Mechanism of ECM-induced dormancy and chemoresistance in A549 human lung carcinoma cells. , 2018, Oncology reports.

[9]  J. Aguirre-Ghiso,et al.  Emerging Topics on Disseminated Cancer Cell Dormancy and the Paradigm of Metastasis , 2018 .

[10]  D. Lauffenburger,et al.  A Model of Dormant-Emergent Metastatic Breast Cancer Progression Enabling Exploration of Biomarker Signatures* , 2018, Molecular & Cellular Proteomics.

[11]  A. Wells,et al.  Inflammatory cytokine IL-8/CXCL8 promotes tumour escape from hepatocyte-induced dormancy , 2017, British Journal of Cancer.

[12]  Xiyun Deng,et al.  3D modeling of cancer stem cell niche , 2017, Oncotarget.

[13]  C. Logsdon,et al.  The immune system in cancer metastasis: friend or foe? , 2017, Journal of Immunotherapy for Cancer.

[14]  Samira M. Azarin,et al.  Immobilization platform to induce quiescence in dormancy-capable cancer cells , 2017 .

[15]  Donald E Ingber,et al.  Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro. , 2017, Cell reports.

[16]  D. Cerf,et al.  Three Dimensional Tumor Engineering by Co-Culture of Breast Tumor and Endothelial Cells Using a Hyaluronic Acid Hydrogel Model , 2017 .

[17]  Thrimoorthy Potta,et al.  Chemomechanically engineered 3D organotypic platforms of bladder cancer dormancy and reactivation. , 2017, Biomaterials.

[18]  Shreyas S. Rao,et al.  Biomimetic strategies to recapitulate organ specific microenvironments for studying breast cancer metastasis , 2017, International journal of cancer.

[19]  Brian A. Aguado,et al.  Engineering the pre-metastatic niche , 2017, Nature Biomedical Engineering.

[20]  H. Levine,et al.  EMT and MET: necessary or permissive for metastasis? , 2017, bioRxiv.

[21]  Michael R. Padgen,et al.  Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments , 2017, Nature Cell Biology.

[22]  R. Gomis,et al.  Tumor cell dormancy , 2017, Molecular oncology.

[23]  J. Condeelis,et al.  Mechanism of early dissemination and metastasis in Her2+ mammary cancer , 2016, Nature.

[24]  L. Griffith,et al.  A liver microphysiological system of tumor cell dormancy and inflammatory responsiveness is affected by scaffold properties. , 2016, Lab on a chip.

[25]  Samira M. Azarin,et al.  Enhanced Survival with Implantable Scaffolds That Capture Metastatic Breast Cancer Cells In Vivo. , 2016, Cancer research.

[26]  C. McCall,et al.  Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone , 2016, Science Translational Medicine.

[27]  Samira M. Azarin,et al.  Extracellular matrix mediators of metastatic cell colonization characterized using scaffold mimics of the pre-metastatic niche. , 2016, Acta biomaterialia.

[28]  Yi-Chen Wu,et al.  From competency to dormancy: a 3D model to study cancer cells and drug responsiveness , 2016, Journal of Translational Medicine.

[29]  M. Ihnat,et al.  Targeting dormant micrometastases: rationale, evidence to date and clinical implications , 2016, Therapeutic advances in medical oncology.

[30]  J. Aguirre-Ghiso,et al.  The Relationship Between Dormant Cancer Cells and Their Microenvironment. , 2016, Advances in cancer research.

[31]  Ji Yi,et al.  In vivo capture and label-free detection of early metastatic cells , 2015, Nature Communications.

[32]  L. Bourguignon,et al.  Identification of novel drugs to target dormant micrometastases , 2015, BMC Cancer.

[33]  D. Kaplan,et al.  Tissue engineering a surrogate niche for metastatic cancer cells. , 2015, Biomaterials.

[34]  Steven J. Greco,et al.  Investigating Breast Cancer Cell Behavior Using Tissue Engineering Scaffolds , 2015, PloS one.

[35]  Cyrus M. Ghajar.  Metastasis prevention by targeting the dormant niche , 2015, Nature Reviews Cancer.

[36]  A. Mastro,et al.  Dormancy and growth of metastatic breast cancer cells in a bone-like microenvironment , 2015, Clinical & Experimental Metastasis.

[37]  J. Pollard,et al.  Immune cell promotion of metastasis , 2015, Nature Reviews Immunology.

[38]  S. Ramaswamy,et al.  Bioengineered implantable scaffolds as a tool to study stromal-derived factors in metastatic cancer models. , 2014, Cancer research.

[39]  F. Garrido,et al.  Metastases in immune-mediated dormancy: a new opportunity for targeting cancer. , 2014, Cancer research.

[40]  L. Griffith,et al.  Spontaneous dormancy of metastatic breast cancer cells in an all human liver microphysiologic system , 2014, British Journal of Cancer.

[41]  S. Plymate,et al.  Prostate cancer xenografts engineered from 3D precision-porous poly(2-hydroxyethyl methacrylate) hydrogels as models for tumorigenesis and dormancy escape. , 2014, Biomaterials.

[42]  P. Bragado,et al.  Mechanisms of disseminated cancer cell dormancy: an awakening field , 2014, Nature Reviews Cancer.

[43]  Anna V. Taubenberger,et al.  A humanized tissue-engineered in vivo model to dissect interactions between human prostate cancer cells and human bone , 2014, Clinical and Experimental Metastasis.

[44]  M. Hoenerhoff,et al.  Combined SFK/MEK inhibition prevents metastatic outgrowth of dormant tumor cells. , 2014, The Journal of clinical investigation.

[45]  A. Tutt,et al.  A novel model of dormancy for bone metastatic breast cancer cells. , 2013, Cancer research.

[46]  D. Mukhopadhyay,et al.  Detecting and targeting tumor relapse by its resistance to innate effectors at early recurrence , 2013, Nature Medicine.

[47]  Mina J. Bissell,et al.  The perivascular niche regulates breast tumor dormancy , 2013, Nature Cell Biology.

[48]  Alan Wells,et al.  The dormancy dilemma: quiescence versus balanced proliferation. , 2013, Cancer research.

[49]  P. Hauser,et al.  Suppression and Activation of the Malignant Phenotype by Extracellular Matrix in Xenograft Models of Bladder Cancer: A Model for Tumor Cell “Dormancy” , 2013, PloS one.

[50]  P. Bragado,et al.  Metastasis Awakening: Targeting dormant cancer , 2013, Nature Medicine.

[51]  S. Kleffel,et al.  Tumor dormancy and cancer stem cells: two sides of the same coin? , 2013, Advances in experimental medicine and biology.

[52]  S. Steinberg,et al.  Effect of inhibition of the lysophosphatidic acid receptor 1 on metastasis and metastatic dormancy in breast cancer. , 2012, Journal of the National Cancer Institute.

[53]  Jeffrey E. Green,et al.  An in vitro system to study tumor dormancy and the switch to metastatic growth. , 2011, Journal of visualized experiments : JoVE.

[54]  P. Bragado,et al.  ERK1/2 and p38α/β Signaling in Tumor Cell Quiescence: Opportunities to Control Dormant Residual Disease , 2011, Clinical Cancer Research.

[55]  Daniel Benten,et al.  Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells , 2011, Hepatology.

[56]  C. Klein.  Framework models of tumor dormancy from patient-derived observations. , 2011, Current opinion in genetics & development.

[57]  J. Settleman,et al.  EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer , 2010, Oncogene.

[58]  R. M. Simpson,et al.  Metastatic growth from dormant cells induced by a col-I-enriched fibrotic environment. , 2010, Cancer research.

[59]  David J. Mooney,et al.  Growth Factors, Matrices, and Forces Combine and Control Stem Cells , 2009, Science.

[60]  R. Raychowdhury,et al.  Transcriptional switch of dormant tumors to fast-growing angiogenic phenotype. , 2009, Cancer research.

[61]  J. Massagué,et al.  Molecular basis of metastasis. , 2008, The New England journal of medicine.

[62]  George Poste,et al.  The "seed and soil" hypothesis revisited. , 2008, The Lancet. Oncology.

[63]  S. Lockett,et al.  Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton. , 2008, Cancer research.

[64]  J. Aguirre-Ghiso,et al.  Models, mechanisms and clinical evidence for cancer dormancy , 2007, Nature Reviews Cancer.

[65]  S. Rafii,et al.  Preparing the "soil": the premetastatic niche. , 2006, Cancer research.

[66]  E. Vogler,et al.  Extended-term culture of bone cells in a compartmentalized bioreactor. , 2006, Tissue engineering.

[67]  Brian K Rutt,et al.  In vivo MRI of cancer cell fate at the single‐cell level in a mouse model of breast cancer metastasis to the brain , 2006, Magnetic resonance in medicine.

[68]  J. Aguirre-Ghiso,et al.  Opposing Roles of Mitogenic and Stress Signaling Pathways in the Induction of Cancer Dormancy , 2006, Cell cycle.

[69]  J. Aguirre-Ghiso,et al.  Tumor cell dormancy induced by p38SAPK and ER-stress signaling: An adaptive advantage for metastatic cells? , 2006, Cancer biology & therapy.

[70]  Lynn Hlatky,et al.  Prolonged dormancy of human liposarcoma is associated with impaired tumor angiogenesis , 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[71]  N. Knowlton,et al.  Analysis of the interaction of extracellular matrix and phenotype of bladder cancer cells , 2006, BMC Cancer.

[72]  S. Rafii,et al.  VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche , 2005, Nature.

[73]  J. Aguirre-Ghiso,et al.  Green Fluorescent Protein Tagging of Extracellular Signal-Regulated Kinase and p38 Pathways Reveals Novel Dynamics of Pathway Activation during Primary and Metastatic Growth , 2004, Cancer Research.

[74]  R. Hurst,et al.  Matrix-dependent plasticity of the malignant phenotype of bladder cancer cells. , 2003, Anticancer research.

[75]  I. Fidler,et al.  The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited , 2003, Nature Reviews Cancer.

[76]  J. Aguirre-Ghiso,et al.  ERKMAPK Activity as a Determinant of Tumor Growth and Dormancy; Regulation by p38SAPK , 2003 .

[77]  J. Aguirre-Ghiso,et al.  ERK(MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38(SAPK). , 2003, Cancer research.

[78]  G. Naumov,et al.  Persistence of solitary mammary carcinoma cells in a secondary site: a possible contributor to dormancy. , 2002, Cancer research.

[79]  J. Aguirre-Ghiso,et al.  Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo. , 2001, Molecular biology of the cell.

[80]  L. Ossowski,et al.  Tumor Dormancy Induced by Downregulation of Urokinase Receptor in Human Carcinoma Involves Integrin and MAPK Signaling , 1999, The Journal of cell biology.

[81]  S Paget,et al.  THE DISTRIBUTION OF SECONDARY GROWTHS IN CANCER OF THE BREAST. , 1889 .