Role of the cyclin-dependent kinase 9-related pathway in mammalian gene expression and human diseases
暂无分享,去创建一个
[1] A. Musarò,et al. Cdk9‐55: A new player in muscle regeneration , 2008, Journal of cellular physiology.
[2] Peter M Fischer,et al. Cyclin-dependent kinase 9: a key transcriptional regulator and potential drug target in oncology, virology and cardiology. , 2008, Trends in pharmacological sciences.
[3] A. Giordano,et al. Cdk9/Cyclin T1 complex: A key player during the activation/differentiation process of normal lymphoid B cells , 2008, Journal of cellular physiology.
[4] K. Knudsen,et al. Review Nuclear Receptor Signaling | The Open Access Journal of the Nuclear Receptor Signaling Atlas AR, the cell cycle, and prostate cancer , 2022 .
[5] A. Giordano,et al. From G0 to S phase: A view of the roles played by the retinoblastoma (Rb) family members in the Rb‐E2F pathway , 2007, Journal of cellular biochemistry.
[6] A. Giordano,et al. Tumor suppressor pRb2/p130 gene and its derived product Spa310 spacer domain as perspective candidates for cancer therapy , 2007, Journal of cellular physiology.
[7] G. Romano. Advances in the field of stem cell research. , 2007, Drug news & perspectives.
[8] L. Meijer,et al. Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases. , 2007, Cancer research.
[9] S. Pikkarainen,et al. Signaling pathways mediating cardiac myocyte gene expression in physiological and stress responses , 2007, Journal of cellular physiology.
[10] A. Giordano,et al. The role of the Cdk9/Cyclin T1 complex in T cell differentiation , 2007, Journal of cellular physiology.
[11] A. Giordano,et al. Carcinogenesis and environment: the cancer stem cell hypothesis and implications for the development of novel therapeutics and diagnostics. , 2007, Frontiers in bioscience : a journal and virtual library.
[12] Danish Sayed,et al. MicroRNAs Play an Essential Role in the Development of Cardiac Hypertrophy , 2007, Circulation research.
[13] J. Ladias,et al. Crystal structure of human cyclin K, a positive regulator of cyclin-dependent kinase 9. , 2007, Journal of molecular biology.
[14] M. Barbacid,et al. Cell cycle kinases in cancer. , 2007, Current opinion in genetics & development.
[15] P. Dirks,et al. Cancer stem cells: at the headwaters of tumor development. , 2007, Annual review of pathology.
[16] G. Romano. Perspectives and controversies in the field of stem cell research. , 2006, Drug news & perspectives.
[17] A. Giordano,et al. Cdk9 phosphorylates p53 on serine 392 independently of CKII , 2006, Journal of cellular physiology.
[18] A. Giordano,et al. RB and cell cycle progression , 2006, Oncogene.
[19] K. Kristiansen,et al. Peroxisome proliferator-activated receptor gamma recruits the positive transcription elongation factor b complex to activate transcription and promote adipogenesis. , 2006, Molecular endocrinology.
[20] J. Brady,et al. Tax Interacts with P-TEFb in a Novel Manner To Stimulate Human T-Lymphotropic Virus Type 1 Transcription , 2006, Journal of Virology.
[21] M. West,et al. EBV EBNA 2 stimulates CDK9-dependent transcription and RNA polymerase II phosphorylation on serine 5 , 2006, Oncogene.
[22] A. Gartel,et al. CDK9 Phosphorylates p53 on Serine Residues 33, 315 and 392 , 2006, Cell cycle.
[23] A. Giordano,et al. MyoD recruits the cdk9/cyclin T2 complex on Myogenic‐genes regulatory regions , 2006, Journal of cellular physiology.
[24] H. Zhen,et al. Survivin expression and its relation with proliferation, apoptosis, and angiogenesis in brain gliomas , 2005, Cancer.
[25] X. Graña,et al. Cyclin T1 Expression Is Regulated by Multiple Signaling Pathways and Mechanisms during Activation of Human Peripheral Blood Lymphocytes1 , 2005, The Journal of Immunology.
[26] M. Barbacid,et al. Mammalian cyclin-dependent kinases. , 2005, Trends in biochemical sciences.
[27] G. Romano. The role of adult stem cells in carcinogenesis. , 2005, Drug news & perspectives.
[28] N. Pedersen,et al. Analysis of the epidermal growth factor receptor specific transcriptome: Effect of receptor expression level and an activating mutation , 2005, Journal of cellular biochemistry.
[29] W. Plunkett,et al. Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death. , 2005, Blood.
[30] P. Dent,et al. Characterization of Cdk9(55) and differential regulation of two Cdk9 isoforms. , 2005, Gene.
[31] C. H. Herrmann,et al. Differential localization and expression of the Cdk9 42k and 55k isoforms , 2005, Journal of cellular physiology.
[32] A. Giordano,et al. Cdk9 regulates neural differentiation and its expression correlates with the differentiation grade of neuroblastoma and PNET tumors , 2005, Cancer biology & therapy.
[33] Michael S Lauer,et al. Left ventricular hypertrophy: the next treatable, silent killer? , 2004, JAMA.
[34] S. Pileri,et al. CDK9/CYCLIN T1 expression during normal lymphoid differentiation and malignant transformation , 2004, The Journal of pathology.
[35] J. Borst,et al. CD27 Is Acquired by Primed B Cells at the Centroblast Stage and Promotes Germinal Center Formation1 , 2004, The Journal of Immunology.
[36] Ching-Jin Chang,et al. Autocrine/Paracrine Secreted Frizzled-related Protein 2 Induces Cellular Resistance to Apoptosis , 2004, Journal of Biological Chemistry.
[37] L. Johnson,et al. Protein Kinase Inhibitors: Insights into Drug Design from Structure , 2004, Science.
[38] C. Cinti,et al. How does a normal human cell become a cancer cell? , 2003, Journal of experimental & clinical cancer research : CR.
[39] G. Romano. Gene transfer in experimental medicine. , 2003, Drug news & perspectives.
[40] D. Price,et al. Identification of a novel isoform of Cdk9. , 2003, Gene.
[41] A. Baldi,et al. Cyclin T: Three forms for different roles in physiological and pathological functions , 2003, Journal of cellular physiology.
[42] A. Giordano,et al. Activation and function of cyclin T–Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy , 2002, Nature Medicine.
[43] A. Giordano,et al. Cdk9, a member of the cdc2-like family of kinases, binds to gp130, the receptor of the IL-6 family of cytokines , 2002, Oncogene.
[44] P. Stiegler,et al. Activation of MyoD-dependent transcription by cdk9/cyclin T2 , 2002, Oncogene.
[45] A. Giordano,et al. Physical interaction between pRb and cdk9/cyclinT2 complex , 2002, Oncogene.
[46] M. Siddiqui,et al. Structure, expression, and functional characterization of the mouse CLP-1 gene. , 2002, Gene.
[47] B. Peterlin,et al. P-TEFb Containing Cyclin K and Cdk9 Can Activate Transcription via RNA* , 2002, The Journal of Biological Chemistry.
[48] A. Giordano,et al. CDK9: From Basal Transcription to Cancer and AIDS , 2002, Cancer biology & therapy.
[49] H. Nakshatri,et al. Transformation of interleukin-3-dependent cells without participation of Stat5/bcl-xL: cooperation of akt with raf/erk leads to p65 nuclear factor kappaB-mediated antiapoptosis involving c-IAP2. , 2001, Blood.
[50] P. Sharp,et al. Positive Transcription Elongation Factor b Phosphorylates hSPT5 and RNA Polymerase II Carboxyl-terminal Domain Independently of Cyclin-dependent Kinase-activating Kinase* , 2001, The Journal of Biological Chemistry.
[51] Chawnshang Chang,et al. Androgen Receptor Interacts with the Positive Elongation Factor P-TEFb and Enhances the Efficiency of Transcriptional Elongation* , 2001, The Journal of Biological Chemistry.
[52] A. Rice,et al. Antiapoptotic Function of Cdk9 (TAK/P-TEFb) in U937 Promonocytic Cells , 2001, Journal of Virology.
[53] J. Choe,et al. Regulation of CD27 expression in the course of germinal center B cell differentiation: the pivotal role of IL‐10 , 2000, European journal of immunology.
[54] A. Rice,et al. Genomic organization and characterization of promoter function of the human CDK9 gene. , 2000, Gene.
[55] P. Stiegler,et al. Genomic organization, promoter analysis, and chromosomal mapping of the mouse gene encoding Cdk9 , 2000, Journal of cellular biochemistry.
[56] J. Dyck,et al. Identification of genes regulated during mechanical load-induced cardiac hypertrophy. , 2000, Journal of molecular and cellular cardiology.
[57] D. Price. P-TEFb, a Cyclin-Dependent Kinase Controlling Elongation by RNA Polymerase II , 2000, Molecular and Cellular Biology.
[58] D. Chen,et al. Requirement for a Kinase-specific Chaperone Pathway in the Production of a Cdk9/Cyclin T1 Heterodimer Responsible for P-TEFb-mediated Tat Stimulation of HIV-1 Transcription* , 2000, The Journal of Biological Chemistry.
[59] Junmin Peng,et al. Cyclin K Functions as a CDK9 Regulatory Subunit and Participates in RNA Polymerase II Transcription* , 1999, The Journal of Biological Chemistry.
[60] M. Kasten,et al. Regulatory functions of Cdk9 and of cyclin T1 in HIV Tat transactivation pathway gene expression , 1999, Journal of cellular biochemistry.
[61] B. Calabretta,et al. Multiple Signaling Pathways of the Insulin-Like Growth Factor 1 Receptor in Protection from Apoptosis , 1999, Molecular and Cellular Biology.
[62] G. Romano,et al. Dissociation between resistance to apoptosis and the transformed phenotype in IGF‐I receptor signaling , 1999, Journal of cellular biochemistry.
[63] X. Graña,et al. Upregulation of cyclin T1/CDK9 complexes during T cell activation , 1998, Oncogene.
[64] A. Rice,et al. Tat-Associated Kinase, TAK, Activity Is Regulated by Distinct Mechanisms in Peripheral Blood Lymphocytes and Promonocytic Cell Lines , 1998, Journal of Virology.
[65] A. Giordano,et al. Cloning of murine CDK9/PITALRE and its tissue‐specific expression in development , 1998, Journal of cellular physiology.
[66] A. Giordano,et al. The standpoint of AIDS research and therapy programs. , 1998, Anticancer research.
[67] J. Milton,et al. Identification of multiple cyclin subunits of human P-TEFb. , 1998, Genes & development.
[68] A. Giordano,et al. PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[69] P. Luciw,et al. Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene product , 1987, Nature.
[70] James R Bischoff,et al. CDK inhibitors in cancer therapy: what is next? , 2008, Trends in pharmacological sciences.
[71] T. Cheng,et al. The CDK inhibitors: potential targets for therapeutic stem cell manipulations? , 2008, Gene Therapy.
[72] A. Giordano,et al. Abrogation of signal-dependent activation of the cdk9/cyclin T2a complex in human RD rhabdomyosarcoma cells , 2007, Cell Death and Differentiation.
[73] Hilmar Weinmann,et al. Drug discovery process for kinase inhibitors. , 2005, Chembiochem : a European journal of chemical biology.
[74] Yusuke Nakamura,et al. Cyclin K as a direct transcriptional target of the p53 tumor suppressor. , 2002, Neoplasia.
[75] A. Giordano,et al. Distinct regions of cyclinT1 are required for binding to CDK9 and for recruitment to the HIV‐1 Tat/TAR complex , 2001, Journal of cellular biochemistry. Supplement.
[76] A. Giordano,et al. Transcriptional activity of P-TEFb kinase in vivo requires the C-terminal domain of RNA polymerase II. , 2000 .
[77] G. Romano,et al. Insulin and IGF-I Receptors Signaling in Protection from Apoptosis , 1999, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.