"B-cell" mitogenicity of carragheenan in mouse.

Abstract Carragheenan, a reported toxic agent for macrophages, has been studied for its properties of stimulation of mouse lymphocytes, by measuring the amount of incorporation of tritiated thymidine in cultures of lymphocytes in vitro . Unequivocal evidence has been obtained, concluding that carragheenan selectively activates mouse “B” cells from each strain tested, with the exception of C3H/He mice. Carragheenan probably acts on a subpopulation of B cells different from the populations stimulated by dextran sulfate and LPS.

[1]  S. Otani,et al.  Effects of carrageenan on immune responses. Studies on the macrophage dependency of various antigens after treatment with carrageenan. , 1977, Journal of immunology.

[2]  R. Schwartz,et al.  Separation of murine lymphoid cells using nylon wool columns. Recovery of the B cell-enriched population. , 1974, Transplantation.

[3]  J. Salvaggio,et al.  The effect of carrageenan on the establishment of delayed hypersensitivity. , 1971, International archives of allergy and applied immunology.

[4]  R. Graham,et al.  Spectrum and possible mechanism of carrageenan cytotoxicity. , 1971, The American journal of pathology.

[5]  G. Chaouat,et al.  Influence of reticuloendothelial blockade on the induction of tolerance and immunity by polysaccharides. , 1976, Immunology.

[6]  H. Schwartz,et al.  The effect of carrageenan on delayed hypersensitivity reactions. , 1969, Journal of immunology.

[7]  M. Poupon,et al.  Splenic modifications induced by cyclophosphamide in C3H/He, nude, and "B" mice. , 1977, Journal of immunology.

[8]  W. J. Cruickshank,et al.  Evaluation of carrageenan as an immunosuppressive agent and mediator of intravascular coagulation. , 1976, Biomedicine / [publiee pour l'A.A.I.C.I.G.].

[9]  A. C. Allison,et al.  AN EXAMINATION OF THE CYTOTOXIC EFFECTS OF SILICA ON MACROPHAGES , 1966, The Journal of experimental medicine.

[10]  T. Diamantstein,et al.  Stimulation of DNA synthesis in mouse lymphoid cells by polyanions in vitro. I. Target cells and possible mode of action , 1973, European journal of immunology.

[11]  Elizabeth Simpson,et al.  A rapid method for the isolation of functional thymus‐derived murine lymphocytes , 1973, European journal of immunology.

[12]  J. Salvaggio,et al.  Suppression of in vitro antigen-induced lymphocyte transformation by carrageenan, a macrophage-toxic agent. , 1971, Journal of immunology.

[13]  I. Ly,et al.  Separation of mouse spleen cells by passage through columns of sephadex G-10. , 1974, Journal of immunological methods.

[14]  T. Diamantstein,et al.  Polyanions and lipopolysaccharide acts on different subpopulations of B cells , 1974, Nature.

[15]  M. Poupon,et al.  Evidence for splenic suppressor cells in C3H/He, T-cell-deprived C3H/He, and nude mice bearing a 3-methylcholanthrene-induced fibrosarcoma. , 1976, Journal of the National Cancer Institute.