The antiplasmodial activity of norcantharidin analogs.
暂无分享,去创建一个
B. Tekwani | S. Duke | A. McCluskey | C. Gordon | T. Hill | S. Stewart | Joanna Bajsa | Rajnish Sahu
[1] A. McCluskey,et al. Synthesis and biological activity of Delta-5,6-norcantharimides: importance of the 5,6-bridge. , 2010, European journal of medicinal chemistry.
[2] I. Bertini,et al. Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin. , 2009, Journal of medicinal chemistry.
[3] B. Tekwani,et al. Plasmodium falciparum serine/threonine phoshoprotein phosphatases (PPP): from housekeeper to the 'holy grail'. , 2008, Current drug targets.
[4] E. Winzeler. Malaria research in the post-genomic era , 2008, Nature.
[5] M. Kizaki,et al. Cantharidin induces apoptosis of human multiple myeloma cells via inhibition of the JAK/STAT pathway , 2008, Cancer science.
[6] G. McFadden,et al. Malaria: Differential parasite drive , 2007, Nature.
[7] S. Ackland,et al. Norcantharimides, synthesis and anticancer activity: Synthesis of new norcantharidin analogues and their anticancer evaluation. , 2007, Bioorganic & medicinal chemistry.
[8] B. Tekwani,et al. A survey of synthetic and natural phytotoxic compounds and phytoalexins as potential antimalarial compounds. , 2007, Biological & pharmaceutical bulletin.
[9] W. Boland,et al. Intraspecific transfer of cantharidin within selected members of the family Meloidae (Insecta: Coleoptera). , 2007, Journal of insect physiology.
[10] S. Ackland,et al. Heterocyclic substituted cantharidin and norcantharidin analogues--synthesis, protein phosphatase (1 and 2A) inhibition, and anti-cancer activity. , 2007, Bioorganic & medicinal chemistry letters.
[11] G. Fall,et al. Protein phosphatase 1, a Plasmodium falciparum essential enzyme, is exported to the host cell and implicated in the release of infectious merozoites , 2006, Cellular microbiology.
[12] R. Coppel,et al. A Maurer's cleft–associated protein is essential for expression of the major malaria virulence antigen on the surface of infected red blood cells , 2006, The Journal of cell biology.
[13] R. Tarran,et al. The Cystic Fibrosis Transmembrane Conductance Regulator Is Regulated by a Direct Interaction with the Protein Phosphatase 2A* , 2005, Journal of Biological Chemistry.
[14] G. Tsokos,et al. Protein phosphatase 2A is a negative regulator of IL-2 production in patients with systemic lupus erythematosus. , 2005, The Journal of clinical investigation.
[15] David A. Fidock,et al. Antimalarial drug discovery: efficacy models for compound screening , 2004, Nature Reviews Drug Discovery.
[16] A. McCluskey,et al. Modified norcantharidins; synthesis, protein phosphatases 1 and 2A inhibition, and anticancer activity. , 2004, Bioorganic & medicinal chemistry letters.
[17] A. McCluskey,et al. Protein phosphatase inhibition: structure based design. Towards new therapeutic agents. , 2004, Current pharmaceutical design.
[18] C. van Hoof,et al. Phosphatases in apoptosis: to be or not to be, PP2A is in the heart of the question. , 2003, Biochimica et biophysica acta.
[19] Adam McCluskey,et al. Cantharidin analogues: synthesis and evaluation of growth inhibition in a panel of selected tumour cell lines. , 2003, Bioorganic chemistry.
[20] A. McCluskey,et al. Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies. , 2002, Journal of medicinal chemistry.
[21] S. Ackland,et al. Anticancer Activity and Protein Phosphatase 1 and 2A Inhibition of a New Generation of Cantharidin Analogues , 2002, Investigational New Drugs.
[22] A. McCluskey,et al. Small molecule inhibitors of serine/threonine protein phosphatases. , 2001, Mini reviews in medicinal chemistry.
[23] V. Janssens,et al. Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. , 2001, The Biochemical journal.
[24] T. Mészáros,et al. Inhibition of serine/threonine-specific protein phosphatases causes premature activation of cdc2MsF kinase at G2/M transition and early mitotic microtubule organisation in alfalfa. , 2000, The Plant journal : for cell and molecular biology.
[25] B. Hemmings,et al. Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Calpha. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[26] A. Nairn,et al. A molecular modeling analysis of the binding interactions between the okadaic acid class of natural product inhibitors and the Ser-Thr phosphatases, PP1 and PP2A. , 1997, Bioorganic & medicinal chemistry.
[27] M. Yanagida,et al. The regulatory subunits of fission yeast protein phosphatase 2A (PP2A) affect cell morphogenesis, cell wall synthesis and cytokinesis , 1996, Genes to cells : devoted to molecular & cellular mechanisms.
[28] G. Wang,et al. Medical uses of mylabris in ancient China and recent studies. , 1989, Journal of ethnopharmacology.
[29] L. C. Nickolls,et al. Poisoning by Cantharidin , 1954, British medical journal.