Analysis on the composition of 481 neonates with congenital malformation and their associated factors

Objectives To retrospectively investigate the changes in incidence and types of congenital malformation over the past 10 years.To analyze the risk factors related to congenital malformation including hazardous exposure during pregnancy,understand the status of congenital malformation update and explore the strategies to reduce congenital malformation.Methods Data of all malformed neonates were reviewed during the past 10 years.Rate of prenatal care,types of malformation,and prenatal exposure to risk factors were analyzed.Chi-square test was used to analyze the statistic significance.Results Prenatal examination was significantly linked to reduce incidence and severity of congenital malformation.Congenital heart diseases were the most common types of malformation.Nervous system malformation has been decreasing over the past 10 years.Certain risk factors,such as maternal sexually transmitted diseases(STD)and intrau-tetine infection have increased in recent years.Conclusions Proper prenatal care,screening of impaired fetus with ultrasonographic examination and prenatal chromosomal studies,and reduction of maternal STD rate and intrauterine infection rate are effective ways to reduce congenital malformation.