Organ Printing as an Information Technology

Abstract Organ printing is defined as a layer by layer additive robotic computer-aided biofabrication of functional 3D organ constructs with using self-assembling tissue spheroids according to digital model. Information technology and computer-aided design softwares are instrumental in the transformation of virtual 3D bioimaging information about human tissue and organs into living biological reality during 3D bioprinting. Information technology enables design blueprints for bioprinting of human organs as well as predictive computer simulation both printing and post-printing processes. 3D bioprinting is now considered as an emerging information technology and the effective application of existing information technology tools and development of new technological platforms such as human tissue and organ informatics, design automation, virtual human organs, virtual organ biofabrication line, mathematical modeling and predictive computer simulations of bioprinted tissue fusion and maturation is an important technological imperative for advancing organ bioprinting.

[1]  Vladimir Mironov,et al.  Organ printing: promises and challenges. , 2008, Regenerative medicine.

[2]  Dong-Woo Cho,et al.  Bioprintable, cell-laden silk fibroin-gelatin hydrogel supporting multilineage differentiation of stem cells for fabrication of three-dimensional tissue constructs. , 2015, Acta biomaterialia.

[3]  V. Mironov,et al.  Age-related analysis of structural, biochemical and mechanical properties of the porcine mitral heart valve leaflets , 2013, Connective tissue research.

[4]  Markus J Buehler,et al.  Materiomics: An ‐omics Approach to Biomaterials Research , 2013, Advanced materials.

[5]  Scaffold informatics: multi-material strategies for tissue scaffolds , 2004, IEEE 30th Annual Northeast Bioengineering Conference, 2004. Proceedings of the.

[6]  Vladimir Mironov,et al.  Organ printing: computer-aided jet-based 3D tissue engineering. , 2003, Trends in biotechnology.

[7]  Brian Derby,et al.  Printing and Prototyping of Tissues and Scaffolds , 2012, Science.

[8]  Vladimir Mironov,et al.  Virtual Biofabrication Line , 2013 .

[9]  V. Mironov,et al.  Toward organ printing: Design characteristics, virtual modelling and physical prototyping vascular segments of kidney arterial tree , 2011 .

[10]  T. Nagaoka,et al.  Development of realistic high-resolution whole-body voxel models of Japanese adult males and females of average height and weight, and application of models to radio-frequency electromagnetic-field dosimetry. , 2004, Physics in medicine and biology.

[11]  Jan de Boer,et al.  Materiomics : High-Throughput Screening of Biomaterial Properties , 2013 .

[12]  Roberto Ballarini,et al.  Materiomics : multiscale mechanics of biological materials and structures , 2013 .

[13]  V. Mironov,et al.  Engineering biological structures of prescribed shape using self-assembling multicellular systems. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[14]  Hod Lipson,et al.  Fab@Home: the personal desktop fabricator kit , 2007 .

[15]  M. Buehler Computational and Theoretical Materiomics: Properties of Biological and de novo Bioinspired Materials , 2010 .

[16]  Jorge Vicente Lopes da Silva,et al.  Scaffold informatics and biomimetic design: three-dimensional medical reconstruction. , 2012, Methods in molecular biology.

[17]  Michael A. K. Liebschner,et al.  Computer-Aided Tissue Engineering , 2012, Methods in Molecular Biology.

[18]  V. Mironov,et al.  Modeling fusion of cellular aggregates in biofabrication using phase field theories. , 2012, Journal of theoretical biology.

[19]  Zheng Li,et al.  Cellular to tissue informatics: approaches to optimizing cellular function of engineered tissue. , 2006, Advances in biochemical engineering/biotechnology.

[20]  P. Heng,et al.  Chinese visible human project , 2006, Clinical anatomy.

[21]  Byeong-Seok Shin,et al.  Visible Korean Human: Its techniques and applications , 2006, Clinical anatomy.

[22]  Wei Sun,et al.  Computer‐aided tissue engineering: overview, scope and challenges , 2004, Biotechnology and applied biochemistry.

[23]  Denis Noble,et al.  The IUPS human physiome project , 2002, Pflügers Archiv.

[24]  Vladimir Mironov,et al.  Dynamics of cell aggregates fusion: Experiments and simulations , 2014 .

[25]  Gabor Forgacs,et al.  Cellular aggregates under pressure , 2010 .