Analysis of expression levels of markers associated with tumor proliferation and angiogenesis in familial adenomatous polyposis

Familial adenomatous polyposis (FAP) is an autosomal dominant hereditary disease with colorectal adenomatous polyps as the main clinical manifestations. The objective of this study was to analyze and compare the expression levels of tumor proliferation and angiogenesis‐related genes in different tissue sections of FAP patients through qPCR, western blot, and immunohistochemistry (IHC) analysis.

[1]  O. Casanovas,et al.  Unraveling the Role of Angiogenesis in Cancer Ecosystems , 2018, Frontiers in Oncology.

[2]  H. DeLisser,et al.  Involvement of TIMP-1 in PECAM-1-mediated tumor dissemination , 2018, International journal of oncology.

[3]  T. Wang,et al.  Tumor angiogenesis and anti-angiogenic gene therapy for cancer , 2018, Oncology letters.

[4]  Liang Cheng,et al.  Prognostic value of programmed death ligand 1, p53, and Ki-67 in patients with advanced-stage colorectal cancer. , 2018, Human pathology.

[5]  B. Mughal,et al.  Reference gene identification and validation for quantitative real-time PCR studies in developing Xenopus laevis , 2018, Scientific Reports.

[6]  Maria Laura DE Marchis,et al.  Desmoid Tumors in Familial Adenomatous Polyposis. , 2017, Anticancer research.

[7]  R. Mohammad,et al.  Vascular Endothelial Growth Factor (VEGF) Signaling in Tumour Vascularization: Potential and Challenges. , 2017, Current vascular pharmacology.

[8]  A. Piotrowska,et al.  Expression of Cell Cycle-related Proteins p16, p27 and Ki-67 Proliferating Marker in Laryngeal Squamous Cell Carcinomas and in Laryngeal Papillomas. , 2017, Anticancer research.

[9]  Yunbao Pan,et al.  P53 and Ki-67 as prognostic markers in triple-negative breast cancer patients , 2017, PloS one.

[10]  M. Hirokawa,et al.  TERT promoter mutations and Ki-67 labeling index as a prognostic marker of papillary thyroid carcinomas: combination of two independent factors , 2017, Scientific Reports.

[11]  Zhe-xuan Lin,et al.  Angiogenesis inhibitors as therapeutic agents in cancer: Challenges and future directions. , 2016, European journal of pharmacology.

[12]  Michael J. Lee,et al.  Familial Adenomatous Polyposis , 2016, Journal of Pediatric Genetics.

[13]  O. Hoekstra,et al.  Glucose Transporter 1 (SLC2A1) and Vascular Endothelial Growth Factor A (VEGFA) Predict Survival After Resection of Colorectal Cancer Liver Metastasis. , 2016, Annals of surgery.

[14]  T. Luukkaala,et al.  VEGFR3 and CD31 as prognostic factors in renal cell cancer. , 2015, Anticancer research.

[15]  C. Thompson,et al.  Diagnosis, surveillance, and treatment strategies for familial adenomatous polyposis: rationale and update , 2014, European journal of gastroenterology & hepatology.

[16]  R. Beştaş,et al.  The correlation between serum VEGF levels and known prognostic risk factors in colorectal carcinoma. , 2008, Hepato-gastroenterology.

[17]  Wei Zhang,et al.  Cdh5 Is Specifically Activated in Glioblastoma Stemlike Cells and Contributes to Vasculogenic Mimicry Induced by Hypoxia Neuro-onco Lo Gy Materials and Methods , 2022 .

[18]  F. Jiang,et al.  The prognostic value of platelet endothelial cell adhesion molecule-1 in non-small-cell lung cancer patients , 2013, Medical Oncology.

[19]  A. Filho,et al.  Clinicopathological correlation and prognostic significance of VEGF-A, VEGF-C, VEGFR-2 and VEGFR-3 expression in colorectal cancer. , 2013, Cancer genomics & proteomics.

[20]  A. Herline,et al.  Adenocarcinomas After Prophylactic Surgery For Familial Adenomatous Polyposis. , 2013, Journal of cancer therapy.

[21]  S. Niclou,et al.  Cancer stem cells and angiogenesis. , 2009, Seminars in Cancer Biology.

[22]  K. Gravdal,et al.  Expression of EZH2 and Ki-67 in colorectal cancer and associations with treatment response and prognosis , 2009, British Journal of Cancer.

[23]  A. Kemona,et al.  Correlation between proliferation markers: PCNA, Ki-67, MCM-2 and antiapoptotic protein Bcl-2 in colorectal cancer. , 2009, Anticancer research.

[24]  R. Scott,et al.  Gene Expression Profiling in Familial Adenomatous Polyposis Adenomas and Desmoid Disease , 2007, Hereditary cancer in clinical practice.

[25]  P. Carmeliet,et al.  Downregulation of vascular endothelial-cadherin expression is associated with an increase in vascular tumor growth and hemorrhagic complications , 2005, Thrombosis and Haemostasis.

[26]  G. Biasco.  Cell proliferation and differentiation in familial adenomatous polyposis (FAP). , 2004, Human pathology.

[27]  R. Odze.  Cell proliferation and differentiation in familial adenomatous polyposis. , 2004, Human pathology.

[28]  E. Cotte,et al.  [Desmoid tumors in familial adenomatous polyposis]. , 2004, Gastroenterologie clinique et biologique.