Clinical update on the use of mesenchymal stem cells in equine orthopaedics.

Stem cells have received much attention in recent times because of their potential to improve healing of othropaedic problems. This manuscript presents the genesis, issues and current state of stem cell treatment in equine medicine. Current literature supports the use of mesenchymal stem cells (MSCs) for treatment of orthopaedic problems.

[1]  G. Beauchamp,et al.  Isolation of equine bone marrow-derived mesenchymal stem cells: a comparison between three protocols. , 2010, Equine veterinary journal.

[2]  C. Kawcak,et al.  Evaluation of adipose‐derived stromal vascular fraction or bone marrow‐derived mesenchymal stem cells for treatment of osteoarthritis , 2009, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[3]  Marjolein C H van der Meulen,et al.  Mesenchymal stem cells and insulin‐like growth factor‐I gene‐enhanced mesenchymal stem cells improve structural aspects of healing in equine flexor digitorum superficialis tendons , 2009, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[4]  C. Kawcak,et al.  Clinical follow-up of horses treated with bone marrow-derived mesenchymal stem cells for musculoskeletal lesions. , 2009 .

[5]  Mandi J. Lopez,et al.  Comparison of chondrogenic potential in equine mesenchymal stromal cells derived from adipose tissue and bone marrow. , 2008, Veterinary surgery : VS.

[6]  L. A. Dahlgren,et al.  Effect of adipose-derived nucleated cell fractions on tendon repair in horses with collagenase-induced tendinitis. , 2008, American journal of veterinary research.

[7]  S. Lehmann,et al.  Cell specific differences between human adipose-derived and mesenchymal-stromal cells despite similar differentiation potentials. , 2008, Experimental cell research.

[8]  L. Fortier,et al.  Regenerative medicine for tendinous and ligamentous injuries of sport horses. , 2008, The Veterinary clinics of North America. Equine practice.

[9]  A. Grodzinsky,et al.  Evaluation of adult equine bone marrow‐ and adipose‐derived progenitor cell chondrogenesis in hydrogel cultures , 2008, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[10]  Roger K. Smith.  Mesenchymal stem cell therapy for equine tendinopathy , 2008, Disability and rehabilitation.

[11]  G. Rossi,et al.  Histology and immunohistochemistry study of ovine tendon grafted with cBMSCs and BMMNCs after collagenase-induced tendinitis , 2008, Veterinary and Comparative Orthopaedics and Traumatology.

[12]  C. Adams,et al.  Effect of intraarticular injection of autologous adipose-derived mesenchymal stem and regenerative cells on clinical signs of chronic osteoarthritis of the elbow joint in dogs. , 2008, Veterinary therapeutics : research in applied veterinary medicine.

[13]  Fabio Carlucci,et al.  Suspension of bone marrow-derived undifferentiated mesenchymal stromal cells for repair of superficial digital flexor tendon in race horses. , 2007, Tissue engineering.

[14]  A. Nixon,et al.  Enhanced early chondrogenesis in articular defects following arthroscopic mesenchymal stem cell implantation in an equine model , 2007, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[15]  W. Richter,et al.  Reduced chondrogenic potential of adipose tissue derived stromal cells correlates with an altered TGFβ receptor and BMP profile and is overcome by BMP‐6 , 2007, Journal of cellular physiology.

[16]  C. Adams,et al.  Effect of adipose-derived mesenchymal stem and regenerative cells on lameness in dogs with chronic osteoarthritis of the coxofemoral joints: a randomized, double-blinded, multicenter, controlled trial. , 2007, Veterinary therapeutics : research in applied veterinary medicine.

[17]  N. Adachi,et al.  Mobilization of bone marrow-derived mesenchymal stem cells into the injured tissues after intraarticular injection and their contribution to tissue regeneration , 2006, Knee Surgery, Sports Traumatology, Arthroscopy.

[18]  G. Im,et al.  Do adipose tissue-derived mesenchymal stem cells have the same osteogenic and chondrogenic potential as bone marrow-derived cells? , 2005, Osteoarthritis and cartilage.

[19]  Masataka Deie,et al.  Meniscal regeneration using tissue engineering with a scaffold derived from a rat meniscus and mesenchymal stromal cells derived from rat bone marrow. , 2005, Journal of biomedical materials research. Part A.

[20]  Masataka Deie,et al.  Meniscal repair using bone marrow-derived mesenchymal stem cells: experimental study using green fluorescent protein transgenic rats. , 2005, The Knee.

[21]  M. Hussein,et al.  Enhancement of the repair of meniscal wounds in the red–white zone (middle third) by the injection of bone marrow cells in canine animal model , 2005, International journal of experimental pathology.

[22]  S. Dyson,et al.  Medical management of superficial digital flexor tendonitis: a comparative study in 219 horses (1992-2000). , 2010, Equine veterinary journal.

[23]  Linda G Griffith,et al.  Engineering principles of clinical cell-based tissue engineering. , 2004, The Journal of bone and joint surgery. American volume.

[24]  Frank P Barry,et al.  Stem cell therapy in a caprine model of osteoarthritis. , 2003, Arthritis and rheumatism.

[25]  Hans Hauner,et al.  Cartilage-like gene expression in differentiated human stem cell spheroids: a comparison of bone marrow-derived and adipose tissue-derived stromal cells. , 2003, Arthritis and rheumatism.

[26]  H. Lorenz,et al.  Multilineage cells from human adipose tissue: implications for cell-based therapies. , 2001, Tissue engineering.

[27]  M. Pittenger,et al.  Multilineage potential of adult human mesenchymal stem cells. , 1999, Science.