Spontaneous symmetry breaking in large scale nervous activity

A theory is outlined of the nature and origin of drug-induced visual hallucination patterns. It is shown that such patterns correspond to blobs or stripes of visual neo-cortical activity. A neuronal circuit is described that generates such patterns whenever its homogeneous resting state becomes unstable. Such a process is shown to be an example of spontaneous symmetry-breaking, similar to that occurring in electro-weak interactions, and in fluid convection. It is suggested that the neuronal instability is produced by the action of hallucinogens on monoamine secreting brain-stem neurons.

[1]  III. Die optischen Wahrnehmungsphänomene in der Hypoglykaemie; pp. 113–128 , 1938 .

[2]  D. Whitteridge,et al.  The representation of the visual field on the cerebral cortex in monkeys , 1961, The Journal of physiology.

[3]  D. Hubel,et al.  Shape and arrangement of columns in cat's striate cortex , 1963, The Journal of physiology.

[4]  A. Ostfeld,et al.  Effects of a hallucinogenic agent in totally blind subjects. , 1963, Archives of ophthalmology.

[5]  M. Jouvet,et al.  The states of sleep. , 1967, Scientific American.

[6]  Lee A. Segel,et al.  Distant side-walls cause slow amplitude modulation of cellular convection , 1969, Journal of Fluid Mechanics.

[7]  L. Foster,et al.  Experience and Theory , 1970 .

[8]  Bernard J. Matkowsky,et al.  A simple nonlinear dynamic stability problem , 1970 .

[9]  W. Foote,et al.  Action of psychotogenic drugs on single midbrain raphe neurons. , 1970, The Journal of pharmacology and experimental therapeutics.

[10]  W. Richards,et al.  The fortification illusions of migraines. , 1971, Scientific American.

[11]  D. W. Goodwin,et al.  State-dependent Effects of Marihuana on Human Memory , 1973, Nature.

[12]  B. Fischer Overlap of receptive field centers and representation of the visual field in the cat's optic tract. , 1973, Vision research.

[13]  F E Bloom,et al.  Activity patterns of catecholamine-containing pontine neurons in the dorso-lateral tegmentum of unrestrained cats. , 1974, Journal of neurobiology.

[14]  D. Hubel,et al.  Uniformity of monkey striate cortex: A parallel relationship between field size, scatter, and magnification factor , 1974, The Journal of comparative neurology.

[15]  G. Gehring,et al.  Co-operative Jahn-Teller effects , 1975 .

[16]  J A Hobson,et al.  Sleep cycle oscillation: reciprocal discharge by two brainstem neuronal groups. , 1975, Science.

[17]  J. Ross,et al.  The pulfrich effect and short-term memory in stereopsis , 1975, Vision Research.

[18]  R. Cole,et al.  Subjective patterns elicited by light flicker , 1975, Vision Research.

[19]  H. Haken Generalized Ginzburg-Landau equations for phase transition-like phenomena in lasers, nonlinear optics, hydrodynamics and chemical reactions , 1975 .

[20]  J A Hobson,et al.  Neuronal excitability modulation over the sleep cycle: a structural and mathematical model. , 1975, Science.

[21]  E. Koschmieder,et al.  Instabilities in Fluid Dynamics , 1977 .

[22]  F. Busse,et al.  Non-linear properties of thermal convection , 1978 .

[23]  Christopher W. Tyler,et al.  Some new entoptic phenomena , 1978, Vision Research.

[24]  F. Busse Patterns of Convection in Plane Layers and in Spherical Shells , 1979 .

[25]  L L Iversen The chemistry of the brain. , 1979, Scientific American.

[26]  J. Pettigrew,et al.  Restoration of visual cortical plasticity by local microperfusion of norepinephrine , 1979, The Journal of comparative neurology.

[27]  David H. Sattinger,et al.  Group theoretic methods in bifurcation theory , 1979 .

[28]  A Gierer,et al.  Generation and regeneration of sequence of structures during morphogenesis. , 1980, Journal of theoretical biology.

[29]  H. Georgi,et al.  Unified theory of elementary‐particle forces , 1980 .

[30]  J. D. Cowan Symmetry Breaking in Embryology and in Neurobiology , 1980 .

[31]  D Marr,et al.  Theory of edge detection , 1979, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[32]  David Marr,et al.  Visual Information Processing: The Structure and Creation of Visual Representations , 1980 .