A compact light source providing high-flux, quasi-monochromatic, tunable X-rays in the laboratory

There is a large performance gap between conventional, electron-impact X-ray sources and synchrotron radiation sources. Electron-impact X-ray sources are compact, low to moderate cost, widely available and can have high total flux, but have limited tunability (broad spectrum bremsstrahlung plus fixed characteristic lines) and low brightness. By contrast, synchrotron radiation sources provide extremely high brightness (coherent flux), are tunable and can be monochromatized to a very high degree. However, they are very large and expensive, and typically operated as national user facilities with limited access. An Inverse Compton Scattering (ICS) X-ray source can bridge this gap by providing a narrow-band, high flux and tunable X-ray source that fits into a laboratory at a cost of a few percent of a large synchrotron facility. It works by colliding a high-power laser beam with a relativistic electron beam, in which case the backscattered photons have an energy in the X-ray regime. This paper will describe the working principle of the Lyncean Compact Light Source, a storage-ring based ICS source, its unique beam properties and recent developments that are expected to increase flux and brightness by an order of magnitude compared to earlier versions. Furthermore, it will illustrate how such an X-ray source can be the cornerstone of a local X-ray facility serving applications from diffraction and imaging to scattering and spectroscopy. An overview of demonstrated and potential applications will be provided.

[1]  Tadeusz Skarzynski Collecting data in the home laboratory: evolution of X-ray sources, detectors and working practices , 2013, Acta crystallographica. Section D, Biological crystallography.

[2]  R. Hajima Status and Perspectives of Compton Sources , 2016 .

[3]  Hans M. Hertz,et al.  Liquid-metal-jet anode electron-impact x-ray source , 2003 .

[4]  Franz Pfeiffer,et al.  Multimodal hard X-ray imaging of a mammography phantom at a compact synchrotron light source. , 2012, Journal of synchrotron radiation.

[5]  R. Ruth,et al.  X-ray phase-contrast tomography with a compact laser-driven synchrotron source , 2015, Proceedings of the National Academy of Sciences.

[6]  Marie Jacquet,et al.  Potential of compact Compton sources in the medical field. , 2015, Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics.

[7]  F. Pfeiffer,et al.  Propagation-based Phase-Contrast X-ray Imaging at a Compact Light Source , 2017, Scientific Reports.

[8]  W. C. Röntgen,et al.  Ueber eine neue Art von Strahlen , 1898 .

[9]  V. Ivashchenko,et al.  THE KHARKOV X-RAY GENERATOR FACILITY NESTOR , 2013 .

[10]  Torben H. Jensen,et al.  Experimental validation of image contrast correlation between ultra-small-angle X-ray scattering and grating-based dark-field imaging using a laser-driven compact X-ray source , 2012 .

[11]  R. Ruth,et al.  Comparison of contrast-to-noise ratios of transmission and dark-field signal in grating-based X-ray imaging for healthy murine lung tissue. , 2013, Zeitschrift fur medizinische Physik.

[12]  Franz Pfeiffer,et al.  Hard X-ray phase-contrast imaging with the Compact Light Source based on inverse Compton X-rays. , 2009, Journal of synchrotron radiation.

[13]  Franz Pfeiffer,et al.  Direct quantitative material decomposition employing grating-based X-ray phase-contrast CT , 2018, Scientific Reports.

[14]  Franz Pfeiffer,et al.  X-ray phase-contrast tomosynthesis of a human ex vivo breast slice with an inverse Compton x-ray source , 2016 .

[15]  Franz Pfeiffer,et al.  Propagation-based phase-contrast x-ray tomography of cochlea using a compact synchrotron source , 2018, Scientific Reports.

[16]  Franz Pfeiffer,et al.  An algebraic iterative reconstruction technique for differential X-ray phase-contrast computed tomography. , 2013, Zeitschrift fur medizinische Physik.

[17]  William Graves,et al.  MIT inverse Compton source concept , 2009 .

[18]  Franz Pfeiffer,et al.  The Munich Compact Light Source: initial performance measures. , 2016, Journal of synchrotron radiation.

[19]  H M Hertz,et al.  A 9 keV electron-impact liquid-gallium-jet x-ray source. , 2008, The Review of scientific instruments.

[20]  Franz Pfeiffer,et al.  Mono-Energy Coronary Angiography with a Compact Synchrotron Source , 2017, Scientific Reports.

[21]  P. Myler,et al.  X-ray structure determination of the glycine cleavage system protein H of Mycobacterium tuberculosis using an inverse Compton synchrotron X-ray source , 2010, Journal of Structural and Functional Genomics.

[22]  J. Urakawa Development of a compact X-ray source based on Compton scattering using a 1.3 GHz superconducting RF accelerating linac and a new laser storage cavity , 2011 .

[23]  Franz Pfeiffer,et al.  In vivo Dynamic Phase-Contrast X-ray Imaging using a Compact Light Source , 2018, Scientific Reports.

[24]  R. Ruth,et al.  Laser-Electron Storage Ring , 1998 .

[25]  D. E. Moncton,et al.  Compact x-ray source based on burst-mode inverse Compton scattering at 100 kHz , 2014, 1409.6954.

[26]  R. Loewen,et al.  A compact light source: Design and technical feasibility study of a laser-electron storage ring X-ray source , 2004 .

[27]  O. J. Luiten,et al.  Smart*Light: A Tabletop, High Brilliance, Monochromatic and Tunable Hard X-ray Source for Imaging and Analysis. , 2018, Microscopy and Microanalysis.

[28]  F. Pfeiffer,et al.  Dynamic In Vivo Chest X-ray Dark-Field Imaging in Mice , 2019, IEEE Transactions on Medical Imaging.

[29]  Franz Pfeiffer,et al.  K-edge subtraction imaging for coronary angiography with a compact synchrotron X-ray source , 2018, PloS one.

[30]  William Graves,et al.  ASU compact XFEL , 2017 .

[31]  Elena Eggl,et al.  Biomedical X-Ray Imaging at the Munich Compact Light Source , 2017 .

[32]  Franz Pfeiffer,et al.  Visualizing treatment delivery and deposition in mouse lungs using in vivo x-ray imaging. , 2019, Journal of controlled release : official journal of the Controlled Release Society.

[33]  G. Potdevin,et al.  Monochromatic computed tomography with a compact laser-driven X-ray source , 2013, Scientific Reports.

[34]  Nobuyuki Nishimori,et al.  Detection of radioactive isotopes by using laser Compton scattered γ-ray beams , 2009 .

[35]  Franz Pfeiffer,et al.  Dose-compatible grating-based phase-contrast mammography on mastectomy specimens using a compact synchrotron source , 2018, Scientific Reports.

[36]  Alessandro Variola,et al.  THE THOMX PROJECT , 2011 .

[37]  Franz Pfeiffer,et al.  Diagnosing and Mapping Pulmonary Emphysema on X-Ray Projection Images: Incremental Value of Grating-Based X-Ray Dark-Field Imaging , 2013, PloS one.

[38]  Franz Pfeiffer,et al.  Trabecular bone anisotropy imaging with a compact laser-undulator synchrotron x-ray source , 2017, Scientific Reports.

[39]  Increased cell survival and cytogenetic integrity by spatial dose redistribution at a compact synchrotron X-ray source , 2017, PloS one.

[40]  Franz Pfeiffer,et al.  Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source , 2012, Proceedings of the National Academy of Sciences.