Significance The recent COVID-19 pandemic requires long-term and real-life applicable antimicrobial skin protection. However, there has been no practical solution to prevent cross-infection while preserving intrinsic skin naturalness. Conventional blocking-based approaches such as gloves cannot preserve the skin sterility and modify the morphology, temperature change rate, and humidity affecting our sensation and comfort. Here, we propose a skin-attachable protection platform copper nanomesh, which prevents cross-infection while maintaining skin naturalness. Copper nanomesh composed of copper coating and interconnected polymer nanofibers kills 99.99% of bacteria and viruses within 1 and 10 min and prevents bacterial cross-infection. The thin and porous structure of the nanomesh enables natural skin-environment interaction in terms of the morphology, temperature change rate, and humidity compared to films or gloves.