Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles.
暂无分享,去创建一个
R G Ulrich | J. Waring | R. Ulrich | C. J. Roberts | C. Roberts | E. Schadt | P. Lum | J. Praestgaard | J F Waring | R A Jolly | R Ciurlionis | P Y Lum | J T Praestgaard | D C Morfitt | B Buratto | C Roberts | E Schadt | R. Ciurlionis | R. Jolly | D. Morfitt | B. Buratto
[1] R. Custer,et al. Hepatotoxicity in Wistar rats following chronic methotrexate administration: a model of human reaction. , 1977, Journal of the National Cancer Institute.
[2] A. Gartel,et al. p53-independent induction of p21WAF1/CIP1 expression in pericentral hepatocytes following carbon tetrachloride intoxication. , 1997, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[3] H. Glatt,et al. Development of hydroxysteroid sulfotransferase-deficient lesions during hepatocarcinogenesis in rats. , 1993, Carcinogenesis.
[4] T. Hughes,et al. Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles. , 2000, Science.
[5] M. Wright,et al. Methapyrilene hepatotoxicity is associated with oxidative stress, mitochondrial disfunction and is prevented by the Ca2+ channel blocker verapamil. , 1998, Toxicology.
[6] Roger Williams,et al. Immunolocalization of regenerating cells after submassive liver necrosis using PCNA staining , 1992, The Journal of pathology.
[7] R. O. Recknagel. Carbon tetrachloride hepatotoxicity. , 1967, Pharmacological reviews.
[8] L. Schiaffonati,et al. Gene expression in liver after toxic injury: analysis of heat shock response and oxidative stress-inducible genes. , 2008, Liver.
[9] D. Wilson,et al. DNA damage cell checkpoint activities are altered in monocrotaline pyrrole-induced cell cycle arrest in human pulmonary artery endothelial cells. , 2000, Toxicology and applied pharmacology.
[10] M. Broggini,et al. Accumulation of DNA strand breaks in cells exposed to methotrexate or N10-propargyl-5,8-dideazafolic acid. , 1988, Cancer research.
[11] A. Campello,et al. Methotrexate: pentose cycle and oxidative stress , 1998, Cell biochemistry and function.
[12] E. Gallagher,et al. The effects of diquat and ciprofibrate on mRNA expression and catalytic activities of hepatic xenobiotic metabolizing and antioxidant enzymes in rat liver. , 1995, Toxicology and applied pharmacology.
[13] T. Massey,et al. Investigation of the role of oxidative stress in amiodarone-induced pulmonary toxicity in the hamster. , 1994, Canadian Journal of Physiology and Pharmacology.
[14] D. Botstein,et al. A gene expression database for the molecular pharmacology of cancer , 2000, Nature Genetics.
[15] S. Chakrabarti,et al. Effect of four-day treatment with carbamazepine at different dose levels on microsomal enzyme induction, drug metabolism and drug toxicity. , 1988, Pharmacology & toxicology.
[16] Yudong D. He,et al. Functional Discovery via a Compendium of Expression Profiles , 2000, Cell.
[17] J. Popp,et al. Effects of methapyrilene on rat hepatic xenobiotic metabolizing enzymes and liver morphology. , 1985, Fundamental and applied toxicology : official journal of the Society of Toxicology.
[18] R. Dunn,et al. Toxicogenomics-based discrimination of toxic mechanism in HepG2 human hepatoma cells. , 2000, Toxicological sciences : an official journal of the Society of Toxicology.
[19] S. Iwase,et al. Concentration-dependent variable effects of etoposide on the cell cycle of CML cells. , 2000, Anticancer research.
[20] G. Church,et al. RNA expression analysis using a 30 base pair resolution Escherichia coli genome array , 2000, Nature Biotechnology.
[21] Christian A. Rees,et al. Systematic variation in gene expression patterns in human cancer cell lines , 2000, Nature Genetics.
[22] L. Schook,et al. Acute hepatotoxicant exposure induces TNFR-mediated hepatic injury and cytokine/apoptotic gene expression. , 2000, Toxicological sciences : an official journal of the Society of Toxicology.
[23] J. Waring,et al. The impact of genomics-based technologies on drug safety evaluation. , 2000, Annual review of pharmacology and toxicology.
[24] M. Higgins,et al. Micronuclei in mice treated with monocrotaline with and without phenobarbital pretreatment , 1995, Environmental and molecular mutagenesis.
[25] R. Lubet,et al. Induction of cytochrome P450 and other drug metabolizing enzymes in rat liver following dietary exposure to Aroclor 1254. , 1991, Toxicology and applied pharmacology.
[26] J. Mesirov,et al. Interpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiation. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[27] T. Fujita,et al. PCBs: structure–function relationships and mechanism of action , 1985, Environmental health perspectives.
[28] Curtis D. Klaassen,et al. Mechanisms of toxicity. , 1969, British medical journal.
[29] R. Jolly,et al. Diquat-induced oxidative damage in hepatic microsomes: effects of antioxidants. , 1991, Free radical biology & medicine.
[30] J. A. Hartigan,et al. A k-means clustering algorithm , 1979 .
[31] S. Belinsky,et al. Mechanism of hepatotoxicity to periportal regions of the liver lobule due to allyl alcohol: role of oxygen and lipid peroxidation. , 1986, The Journal of pharmacology and experimental therapeutics.
[32] Curtis D. Klaassen,et al. Casarett and Doull's Toxicology. The Basic Science of Poisons , 1981 .
[33] Z. Ilic,et al. Cell kinetics of repair after allyl alcohol‐induced liver necrosis in mice , 1996, International journal of experimental pathology.
[34] D. Gerhold,et al. Monitoring expression of genes involved in drug metabolism and toxicology using DNA microarrays. , 2001, Physiological genomics.
[35] J. F. Brown,et al. Comparative Carcinogenicity in Sprague-Dawley Rats of the Polychlorinated Biphenyl Mixtures Aroclors 1016, 1242, 1254, and 1260 , 1998, Toxicological Sciences.
[36] C. Mackerer,et al. The effects of a polychlorinated biphenyl mixture (Aroclor 1254) on liver gluconeogenic enzymes of normal and alloxan-diabetic rats. , 1975, Toxicology.
[37] Lindén Cj. Toxicity of intraperitoneally administered antitumour drugs in athymic rats. , 1989 .
[38] C. D. Klaasen. Casarett & Doull's Toxicology: The Basic Science of Poisons , 1980 .
[39] U. Alon,et al. Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[40] R. Young,et al. Biomedical Discovery with DNA Arrays , 2000, Cell.
[41] M. Comporti. Three models of free radical-induced cell injury. , 1989, Chemico-biological interactions.
[42] W. J. Donarski,et al. Effects of novel antioxidants on carbon tetrachloride-induced lipid peroxidation and toxicity in precision-cut rat liver slices. , 1990, Toxicology and applied pharmacology.
[43] C. V. Smith,et al. Sex differences in diquat-induced hepatic necrosis and DNA fragmentation in Fischer 344 rats. , 2000, Toxicological sciences : an official journal of the Society of Toxicology.
[44] R. Somogyi,et al. Gene Expression Microarray Data Analysis for Toxicology Profiling , 2000, Annals of the New York Academy of Sciences.
[45] P. Ganey,et al. Depletion of neutrophils and modulation of Kupffer cell function in allyl alcohol-induced hepatotoxicity. , 1995, Toxicology.
[46] J. Mesirov,et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. , 1999, Science.
[47] T. Thum,et al. Induction of nuclear transcription factors, cytochrome P450 monooxygenases, and glutathione S-transferase alpha gene expression in Aroclor 1254-treated rat hepatocyte cultures. , 2001, Biochemical pharmacology.
[48] R. Gebhardt,et al. Diethylnitrosamine exposure-responses for DNA damage, centrilobular cytotoxicity, cell proliferation and carcinogenesis in rat liver exhibit some non-linearities. , 1996, Carcinogenesis.
[49] R. Davis,et al. Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[50] J. Sarma,et al. Role of Oxidative Stress in Amiodarone-induced Toxicity , 1997, Journal of cardiovascular pharmacology and therapeutics.
[51] P. H. Bach,et al. Effects of arsenite on hepatic mixed-function oxidase activity in rats. , 1992, Xenobiotica; the fate of foreign compounds in biological systems.
[52] C. Byus,et al. Activation of 3':5'-cyclic AMP-dependent protein kinase and induction of ornithine decarboxylase as early events in induction of mixed-function oxygenases. , 1976, Proceedings of the National Academy of Sciences of the United States of America.
[53] K. Hostetler,et al. Comparative evaluation of amiodarone-induced phospholipidosis and drug accumulation in Fischer-344 and Sprague-Dawley rats. , 1996, Toxicology.
[54] J. Borlakoglu,et al. Evidence for the induction of fatty acid desaturation in proliferating hepatic endoplasmic reticulum in response to treatment with polychlorinated biphenyls. Are fatty acid desaturases cytochrome P-450-dependent monooxygenases? , 1991, The International journal of biochemistry.
[55] E. Yu,et al. Time course of cell cycle-related protein expression in diethylnitrosamine-initiated rat liver. , 1998, Journal of hepatology.
[56] D. Waxman,et al. Xenobiotic induction of P-450 PB-4 (IIB1) and P-450c (IA1) and associated monooxygenase activities in primary cultures of adult rat hepatocytes. , 1991, Xenobiotica; the fate of foreign compounds in biological systems.
[57] L. Bengochea,et al. An experimental model of liver damage and portal hypertension induced by a single dose of monocrotaline. , 1999, Hepato-gastroenterology.
[58] G. Sherlock. Analysis of large-scale gene expression data. , 2000, Current opinion in immunology.
[59] K. Mahaffy. CONCURRENT EXPOSURE OF LEAD, CADMIUM AND ARSENIC: EFFECTS ON TOXICITY AND TISSUE METAL CONCENTRATION IN RAT , 1981 .
[60] E. Glover,et al. Studies on the mechanism of action of halogenated aromatic hydrocarbons. , 1985, Clinical physiology and biochemistry.