Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes

The genetic basis of the autoimmune disease type 1 diabetes (T1D) has now been largely determined, so now we can compare these findings with emerging genetic knowledge of disorders and phenotypes that have been negatively or positively associated with T1D historically. Here, we assessed the role in T1D of variants previously reported to be associated with atopic diseases and epithelial barrier function, profilaggrin (), and those that affect the expression levels of the proinflammatory cytokines tumour necrosis factor (TNF)‐α, interleukin (IL)‐1β, interferon (IFN)γ and IL‐18.

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