A Clinical Objective IMRT QA Method Based on Portal Dosimetry and Electronic Portal Imager Device (EPID) Measurement

Clinical objective IMRT QA is a new approach to conduct patient specific IMRT QA by evaluating the QA result based on metrics like the structure dose volume histograms (DVH) on the planning CT image. Different from traditional 2D planar dose based IMRT QA in which all the measurements and evaluations were based on a phantom, clinical objective IMRT QA reveals the direct clinical impact of any measured variation based on the predicted delivered dose to the patient target volumes and critical organs. In this study, we proposed a method to implement the clinical objective IMRT QA procedure by using generally available dosimetry equipment in a radiation oncology clinic. The proposed procedure was tested and validated on five IMRT plans by using a solid water phantom, which served as a test patient, along with total 30 ion chamber measurements. The result showed that the proposed QA procedure successfully achieved the goal of clinical objective IMRT QA. Based on the ion chamber measurements, the QA procedure predicted that the average variations between the planned and the delivered doses were within 1.9%. This method may hold potentials to help radiation oncology clinics to move from the traditional IMRT QA to the clinical objective IMRT QA.

[1]  C. Ling,et al.  Planning, delivery, and quality assurance of intensity-modulated radiotherapy using dynamic multileaf collimator: a strategy for large-scale implementation for the treatment of carcinoma of the prostate. , 1997, International journal of radiation oncology, biology, physics.

[2]  Sharon C Dutton,et al.  On using 3D γ-analysis for IMRT and VMAT pretreatment plan QA. , 2012, Medical physics.

[3]  Stanley Rogers,et al.  Review and Preview , 1965 .

[4]  J. Dempsey,et al.  Quantitative dosimetric verification of an IMRT planning and delivery system. , 1998, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[5]  D. Convery,et al.  The generation of intensity-modulated fields for conformal radiotherapy by dynamic collimation , 1992 .

[6]  Ke Sheng,et al.  3D dose verification using tomotherapy CT detector array. , 2012, International journal of radiation oncology, biology, physics.

[7]  Wendel Dean Renner,et al.  A method for deconvolution of integrated electronic portal images to obtain incident fluence for dose reconstruction , 2005, Journal of applied clinical medical physics.

[8]  A Brahme,et al.  Dosimetric precision requirements in radiation therapy. , 1984, Acta radiologica. Oncology.

[9]  A L Boyer,et al.  Synchronizing dynamic multileaf collimators for producing two-dimensional intensity-modulated fields with minimum beam delivery time. , 1999, International journal of radiation oncology, biology, physics.

[10]  B G Fallone,et al.  Three-dimensional IMRT verification with a flat-panel EPID. , 2005, Medical physics.

[11]  D. Low,et al.  A technique for the quantitative evaluation of dose distributions. , 1998, Medical physics.

[12]  Benjamin E Nelms,et al.  Per-beam, planar IMRT QA passing rates do not predict clinically relevant patient dose errors. , 2011, Medical physics.

[13]  T. Bortfeld IMRT: a review and preview , 2006, Physics in medicine and biology.

[14]  J. Mechalakos,et al.  IMRT commissioning: multiple institution planning and dosimetry comparisons, a report from AAPM Task Group 119. , 2009, Medical physics.

[15]  Jan-Jakob Sonke,et al.  3D Dosimetric verification of volumetric-modulated arc therapy by portal dosimetry. , 2010, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[16]  P. Xia,et al.  Multileaf collimator leaf sequencing algorithm for intensity modulated beams with multiple static segments. , 1998, Medical physics.

[17]  T. Cullip,et al.  Intensity modulation delivery techniques: "step & shoot" MLC auto-sequence versus the use of a modulator. , 2000, Medical physics.