Dossier : Present status of drug from marine origin Enhancing effects of new biological response modifier b-1 , 3 glucan sulfate PS 3 on immune reactions

Glucans have a long history as non-specific biological modulators; however, but the search for optimal chemical configuration is still on. The objective of this study was to evaluate intraperitoneal application of PS3, a sulfated derivative of a (1e>3)-b-D-glucan isolated from sporophytes of Laminaria digitata. PS3 showed significant stimulation of phagocytic activity as well as potentiation of synthesis and release of IL-2 by splenocytes. In addition, PS3 increased NK cell-mediated killing of tumor cells both in vitro and in vivo. When combined, our observations suggest that PS3 is similarly effective as native non-sulfated (1e>3)-b-D-glucan and is generally more active than lentinan. 2007 Elsevier Masson SAS. All rights reserved.

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