Results of pneumonectomy for non-small cell lung cancer.

To assess the role of pneumonectomy for lung cancer and the factors affecting the prognosis, 107 patients who had undergone pneumonectomy for non-small cell lung cancer (NSCLC) between January, 1985 and March, 1996, were analyzed. They included 81 squamous cell carcinoma, 22 adenocarcinoma, 3 large cell carcinoma, and one adenosquamous cell carcinoma, with 8 patients in post-operative stage I, 15 in stage II, 51 in stage IIIA, and 33 in stage IIIB of the disease. The 5-year survival rate was 54.7% in stages I + II, 38.0% in stage IIIA, and <4% in stage IIIB. In stages I-IIIA, the patients with squamous cell carcinoma showed a significantly better prognosis than those with adenocarcinoma (50.6 vs. 0%, p < 0.01). The prognosis was also better, but not statistically significant, for patients with central type compared with those with peripheral type in both all histologic types (58.0 vs. 8.4%) and only squamous cell type (59.3 vs. 18.8%). A better prognosis observed in squamous histologic type or central type seemed to be related to a better N factor. Pneumonectomy remains the treatment of choice for lung cancer, but seems not to be justified for patients with stage IIIB due to their poor prognosis.

[1]  W. Walker,et al.  Initial experience of video assisted thoracoscopic pneumonectomy. , 1995, Thorax.

[2]  I. Yada,et al.  Surgery for T4 lung cancer: the prognoses of T4 lung cancer. , 1994, Japanese journal of clinical oncology.

[3]  F. Pearson,et al.  Current status of surgical resection for lung cancer. , 1994, Chest.

[4]  J. Roth,et al.  A randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIA non-small-cell lung cancer. , 1994, Journal of the National Cancer Institute.

[5]  M. Oda,et al.  Results of Surgical Treatment in Patients with Stage IIIB Non-Small-Cell Lung Cancer , 1991, The Thoracic and cardiovascular surgeon.

[6]  J. Benichou,et al.  Failure of the perioperative PCV neoadjuvant polychemotherapy in resectable bronchogenic non‐small cell carcinoma results from a randomized phase II trial , 1990, Cancer.

[7]  C. Mountain.  Expanded possibilities for surgical treatment of lung cancer. Survival in stage IIIa disease. , 1990, Chest.

[8]  R. Tsuchiya,et al.  Prognosis and survival in resected lung carcinoma based on the new international staging system. , 1988, The Journal of thoracic and cardiovascular surgery.

[9]  H. Popper,et al.  Perioperative adjuvante Chemotherapie mit Bleomycin beim bronchogenen Plattenepithelkarzinom , 1986 .

[10]  M. Gail,et al.  Surgical adjuvant therapy for stage II and stage III adenocarcinoma and large-cell undifferentiated carcinoma. , 1986, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[11]  C. Mountain.  The new International Staging System for Lung Cancer. , 1986, The Surgical clinics of North America.

[12]  D. Girling,et al.  Fifteen-year follow-up of all patients in a study of post-operative chemotherapy for bronchial carcinoma. , 1985, British Journal of Cancer.

[13]  R. Ginsberg,et al.  Modern thirty-day operative mortality for surgical resections in lung cancer. , 1983, The Journal of thoracic and cardiovascular surgery.

[14]  N. Martini,et al.  Complications of surgery in the treatment of carcinoma of the lung. , 1982, Chest.

[15]  M. Kirsh,et al.  Mediastinal metastases in bronchogenic carcinoma: influence of postoperative irradiation, cell type, and location. , 1982, The Annals of thoracic surgery.

[16]  C. Gebitekin,et al.  Results of pneumonectomy for cancer in patients with limited ventilatory function. , 1995, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[17]  F. Chiarotti,et al.  Results of surgical treatment of stage IIIA non-small cell lung cancer. , 1995, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[18]  A. Mearns,et al.  Results of surgical treatment of stage III lung cancer. , 1994, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[19]  P. Goldstraw,et al.  Surgical management of non-small-cell lung cancer with ipsilateral mediastinal node metastasis (N2 disease). , 1994, The Journal of thoracic and cardiovascular surgery.

[20]  J. Dussek,et al.  Survival and prognosis following resection of primary non small cell bronchogenic carcinoma. , 1991, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

[21]  M. Tarkka,et al.  Survival after surgical treatment of lung cancer. , 1988, Scandinavian journal of thoracic and cardiovascular surgery.

[22]  M. Gail,et al.  Effects of postoperative mediastinal radiation on completely resected stage II and stage III epidermoid cancer of the lung. , 1986, The New England journal of medicine.